MINERVA SIGNED
MIcrobiota-Gut-BraiN EngineeRed platform to eVAluate intestinal microflora impact on brain functionality
Total Cost €
0EC-Contrib. €
0Partnership
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0MINERVA project word cloud
Explore the words cloud of the MINERVA project. It provides you a very rough idea of what is the project "MINERVA" about.
Project "MINERVA" data sheet
The following table provides information about the project.
| Coordinator |
POLITECNICO DI MILANO
Organization address contact info |
| Coordinator Country | Italy [IT] |
| Project website | http://www.minerva.polimi.it/ |
| Total cost | 1˙999˙194 € |
| EC max contribution | 1˙999˙194 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-COG |
| Funding Scheme | ERC-COG |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-05-01 to 2022-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | POLITECNICO DI MILANO | IT (MILANO) | coordinator | 1˙999˙194.00 |
Map
Project objective
What is the relation between the intestinal microflora and the brain in the development of neurodegenerative disorders like Alzheimer's and Parkinson's disease? A functional relation between the intestinal microflora (microbiota) and the brain, referred to as the “microbiota-gut-brain axis”, was hypothesized more than 100 years ago but only recently has been re-evaluated becoming a new, exciting hypothesis in neuroscience. We have the proof that aging, bad alimentary habits, poor food quality and stress can affect our intestinal microbiota: the impact of this modification on brain functionality has been observed but the absence of suitable research tools does not allow verifying this research hypothesis. My aim is to overcome this limitation through a bioengineering approach: I will develop the first microbiota-gut-brain platform relying on three miniaturized microfluidic compartments, representing in vitro the most important features of microbiota-brain interaction. Once validated, my platform will be challenged in healthy and neurodegenerative scenarios by using human complete microbiota. MINERVA has a ground breaking potential: the proof of a causal link between intestinal microbiota and brain functionality would completely change the actual scenario, shifting the investigation of neurodegenerative disorders causes from the brain to the body periphery. MINERVA is a high gain project: if its vision succeeds, neurodegenerative disorders will benefit from new, cost effective, low invasive preventative and therapeutic strategies based on microbiota management by food ingredient and probiotics with an enormous beneficial impact worldwide. MINERVA will provide a versatile platform that will overcome the strong limitations arising from the current in vivo models and standard in vitro tools: by changing cell type or culturing conditions, it could address microbiota impact not only on neurodegenerative disorders, but also on other severe other-than-nervous pathologies.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2020 |
Diego Albani, Carmen Giordano CURRENT PERSPECTIVES ON THE MICROBIOTA-GUT-BRAIN AXIS IN CHRONIC NEURODEGENERATIVE DISORDERS published pages: 1-12, ISSN: 2384-986X, DOI: 10.4081/scie.2017.641 |
Istituto Lombardo - Accademia di Scienze e Lettere - Rendiconti di Scienze 151 | 2020-04-15 |
| 2019 |
Lucia Boeri, Luca Izzo, Lorenzo Sardelli, Marta Tunesi, Diego Albani, Carmen Giordano Advanced Organ-on-a-Chip Devices to Investigate Liver Multi-Organ Communication: Focus on Gut, Microbiota and Brain published pages: 91, ISSN: 2306-5354, DOI: 10.3390/bioengineering6040091 |
Bioengineering 6/4 | 2019-11-26 |
| 2019 |
Luca Izzo, Marta Tunesi, Lucia Boeri, Matteo Laganà , Carmen Giordano, Manuela Teresa Raimondi Influence of the static magnetic field on cell response in a miniaturized optically accessible bioreactor for 3D cell culture published pages: , ISSN: 1387-2176, DOI: 10.1007/s10544-019-0387-8 |
Biomedical Microdevices 21/1 | 2019-10-03 |
| 2018 |
Ilaria Raimondi, Marta Tunesi, Florencia Andrea Ceppa, Luca Izzo, Carmen Giordano 3D hydrogel-based cell model assays in MINERVA, a microfluidic organ-on chip-engineered platform of gut-brain axis to study neurodegeneration published pages: 136-137, ISSN: 0722-5091, DOI: |
CLINICAL NEUROPATHOLOGY 37 (3) | 2019-04-18 |
| 2018 |
Luca Izzo, Marta Tunesi, Matteo Laganà , Carmen Giordano, Manuela Teresa Raimondi A new Miniaturized Optically Accessible Bioreactor to investigate the microbiota-gut-brain axis: magnetic characterization of the chambers published pages: 490, ISSN: , DOI: |
5th TERMIS World Congress 2018-Proceedings | 2019-04-18 |
| 2017 |
Carmen Giordano, Diego Albani MINERVA: The technological project to boost research on the microbiota-gut-brain axis in chronic neurodegenerative disorders published pages: 48-50, ISSN: 1722-6996, DOI: |
AGRO FOOD INDUSTRY HI-TECH 28 (6) | 2019-04-18 |
| 2018 |
Luca Izzo, Marta Tunesi, Alessandro Marturano-Kruik, Laganà Matteo, Carmen Giordano, Manuela Teresa Raimondi Organ-on-chip platform based on a Miniaturized Optically Accessible Bioreactor: magnetic characterization of the culture chambers published pages: 1-4, ISSN: , DOI: |
Sixth National Congress of Bioengineering-Proceedings | 2019-04-18 |
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