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PHEMDD

Phosphate homeostasis and energy metabolism in Dictyostelium discoideum

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PHEMDD project word cloud

Explore the words cloud of the PHEMDD project. It provides you a very rough idea of what is the project "PHEMDD" about.

adenosine model candidates concentration polyphosphate organism energy serve pi reservoir oxidative modified cellular phosphorylation pyrophosphates eukaryotes understand atp levels homeostasis elucidate currency demands discoideum biological inositol cell functional glycolysis regulated suggesting amoeba relationships dynamic depends energetic metabolomics first steady triphosphate rates inorganic orchestrate surprisingly metabolic universal mitochondria pyrophosphate combination metabolism obviously dramatically function tightly comparatively dictyostelium flux excellent polyp messengers phosphate

Project "PHEMDD" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.ucl.ac.uk/lmcb/users/adolfo-saiardi
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	195˙454.00

Map

Project objective

Adenosine triphosphate (ATP) is the universal biological energy currency. Its cellular concentration is tightly regulated and depends on rates of glycolysis, oxidative phosphorylation, and obviously on phosphate availability. How is phosphate concentration regulated as a function of the cell’s demands? Inositol pyrophosphates, described as metabolic messengers, are excellent candidates to orchestrate phosphate homeostasis and energy metabolism. The research programme proposed here aims to elucidate the relationships between phosphate homeostasis, energy metabolism, and inositol pyrophosphates using the amoeba Dictyostelium discoideum as a model system. This organism has high levels of inositol pyrophosphates and inorganic polyphosphate (polyP) and, surprisingly, a comparatively low level of ATP, suggesting that inositol pyrophosphates may serve as a phosphate reservoir for ATP production. I will use a combination of metabolomics analysis, steady-state and dynamic flux analysis of ATP, polyP, Pi and inositol pyrophosphate levels, and a functional analysis of mitochondria to evaluate the impact of polyP and inositol pyrophosphates on the metabolic/energetic state of this organism. I will investigate the function of polyP, which is induced during development, to understand how and why phosphate homeostasis is so dramatically modified during this process. This will be the first comprehensive analysis of the relationships between phosphate homeostasis and energy metabolism in eukaryotes.

Publications

List of publications.
year	authors and title	journal	last update
2019	Yann DesfougÃ¨res, Miranda S. C. Wilson, Debabrata Laha, Gregory J. Miller, Adolfo Saiardi ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism published pages: 201911431, ISSN: 0027-8424, DOI: 10.1073/pnas.1911431116	Proceedings of the National Academy of Sciences	2019-12-16

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The information about "PHEMDD" are provided by the European Opendata Portal: CORDIS opendata.