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VASCFORM SIGNED

Deformable vascular registration for co-mapping altered hemodynamics with vascular responses,and for introducing a new measure for aneurysm rupture risk assessment: the local surfacegrowth

Total Cost €

0

EC-Contrib. €

0

Partnership

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 VASCFORM project word cloud

Explore the words cloud of the VASCFORM project. It provides you a very rough idea of what is the project "VASCFORM" about.

quantify    methodology    quantification    diameter    angiotensin    correspondence    mice    associate    surface    consecutive    deformable    meshes    difficult    aortic    co    lesion    aneurysm    correlate    patients    asaa    wall    animal    rupture    rate    initiating    effect    maximum    tear    performed    metric    introduce    suspected    sensitive    points    relationship    questions    leads    responsible    infused    media    ascending    direct    potentially    3d    outcome    measured    reflects    map    corresponding    geometry    risk    obtain    mechanics    time    expansion    microenvironment    debated    degree    computational    regional    identification    data    stage    justification    microscopic    uniform    growth    vascular    tools    remodeling    fluid    localized    initiation    exact    registration    hemodynamic    pathology    sacrifice    answer    disturbed    apoe    baseline    local    size    regions    images    indirectly    lastly    clinical    histological    marker    fast    model    hemodynamics    groundwork   

Project "VASCFORM" data sheet

The following table provides information about the project.

Coordinator
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE 

Organization address
address: BATIMENT CE 3316 STATION 1
city: LAUSANNE
postcode: 1015
website: www.epfl.ch

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Switzerland [CH]
 Total cost 187˙419 €
 EC max contribution 187˙419 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2016
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2018
 Duration (year-month-day) from 2018-09-01   to  2020-08-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE CH (LAUSANNE) coordinator 187˙419.00

Map

 Project objective

Growth rate of ascending aortic aneurysm (AsAA) is a rupture risk marker as it potentially reflects a wall remodeling that leads to fast growth. It is measured as the maximum diameter change over time. However, expansion is not uniform but presents localized growth. We propose to develop a methodology based on deformable surface registration tools that will provide correspondence between aortic surface meshes obtained at consecutive time points and quantify vascular surface growth distribution. The direct application of this methodology in animal and clinical research will answer some long debated questions about AsAA pathology. While a cause and effect relationship between hemodynamics and lesion development is long suspected, exact quantification of the responsible hemodynamic factors has not been performed so far. This is because the geometry changes between baseline (measurement of initiating hemodynamics with computational fluid mechanics) and end stage (lesion development), making it difficult to identify corresponding regions at the microscopic level of lesion size. We will use angiotensin II-infused ApoE-/- mice, a model for AsAA, and apply the developed registration methodology to obtain a detailed correspondence between the 3D images, and co-map the complex initiating hemodynamic microenvironment and the histological findings at sacrifice for the identification of disturbed hemodynamics. Furthermore, the local wall expansion can indirectly provide information about aneurysm state. We will associate maximum local growth with the degree of aneurysm initiation (size of media tear) which will be used as a groundwork and pre-clinical justification to introduce the regional growth measurement in clinical risk assessment. Lastly, clinical data from AsAA patients will be used in order to correlate the maximum regional growth with clinical outcome, which will establish a new metric for a more sensitive aneurysm growth quantification.

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The information about "VASCFORM" are provided by the European Opendata Portal: CORDIS opendata.

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