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AIDViC

Antibiotic intracellular delivery via virus-like carriers

Total Cost €

EC-Contrib. €

Partnership

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AIDViC project word cloud

Explore the words cloud of the AIDViC project. It provides you a very rough idea of what is the project "AIDViC" about.

efforts laboratories detrimental mevic materials viruses molecular created natural intracellular preliminary possibility almost resistance exclusively infections expand tackling grant cells payload virus engineering anticancer inspiration therapies performed synthetic macrophages ongoing erc polymers treatment pathogens carriers successfully whereas antibiotics taking starting antibiotic showing safer completely rid delivering drugs effect

Project "AIDViC" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	149˙062 €
EC max contribution	149˙062 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2018-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	149˙062.00

Map

Project objective

Taking inspiration from natural carriers, such as viruses, a new technology has been developed in our laboratories part of an ongoing ERC starting grant project, Molecular Engineering of Virus-like Carriers (MEViC). We created synthetic viruses using polymers and thus safer materials. They are able of delivering high payload of specific drugs into cells with no detrimental effect. While testing for anticancer therapies, we identified a synthetic virus capable of targeting almost exclusively macrophages. We performed preliminary work showing that this can be successfully applied to deliver antibiotics to rid of intracellular pathogens. This has now open a completely new possibility whereas we can expand our technology for the treatment of several infections as well as to contribute to the ongoing efforts in tackling antibiotic resistance.

Publications

List of publications.
year	authors and title	journal	last update
2017	Loris Rizzello, James D. Robertson, Philip M. Elks, Alessandro Poma, Nooshin Daneshpour, Tomasz K. Prajsnar, Dimitrios Evangelopoulos, Julio Ortiz Canseco, Simon Yona, Helen M. Marriott, David H. Dockrell, Simon J. Foster, Bruno De Geest, Stefaan De Koker, Timothy McHugh, Stephen A. Renshaw, Giuseppe Battaglia Targeting mononuclear phagocytes for eradicating intracellular parasites published pages: , ISSN: , DOI: 10.1101/119297		2019-10-15

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The information about "AIDVIC" are provided by the European Opendata Portal: CORDIS opendata.