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NeurIMM

Neuroimmune activation as a novel therapeutic approach for IBD

Total Cost €

EC-Contrib. €

Partnership

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NeurIMM project word cloud

Explore the words cloud of the NeurIMM project. It provides you a very rough idea of what is the project "NeurIMM" about.

nature neurimm prof cells implications tissue cell therapy erc cog enteric designed henrique homeostasis bowel 647274 suffering ibd disease patients protective ibiza disorders immune published inducing immunomodulator damage cancer team commercial al pediatric uncovered intestinal innate patient signaling fernandes gastroenteritis discovery viability 2016 inflammatory reverse grant lymphoid veiga mediated proposes healing axis glial gliainnatesensing et ilc3s restore outcomes

Project "NeurIMM" data sheet

The following table provides information about the project.

Coordinator	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Organization address address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD city: LISBOA postcode: 1400-038 website: http://fchampalimaud.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-09-01 to 2019-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD Organization address address: AVENIDA BRASILIA, CENTRO DE INVESTIGACAO DA FUNDACAO CHAMPALIMAUD city: LISBOA postcode: 1400-038 website: http://fchampalimaud.org/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (LISBOA)	coordinator	150˙000.00

Map

Project objective

NeurIMM has been designed to investigate the commercial and technical viability of a novel, targeted therapy for Inflammatory Bowel Disease (IBD), based on a recently uncovered signaling axis between intestinal type 3 innate lymphoid cells (ILC3s) and enteric glial cells. This discovery by the team of Prof. Henrique Veiga-Fernandes in the ERC CoG grant 647274 ‘GliaInnateSensing’ was recently published in Nature (Ibiza et al, Nature 2016). NeurIMM proposes the use of a glial cell-derived immunomodulator to restore intestinal homeostasis, by inducing a tissue protective immune response. Importantly, this novel therapy will also promote tissue healing to reverse immune-cell mediated tissue damage, leading to improved outcomes for the patient. This could have major implications for patients suffering from IBD. In addition, this approach also has potential as an effective therapy against cancer, (pediatric) gastroenteritis, and other inflammatory disorders.

Publications

List of publications.
year	authors and title	journal	last update
2018	Johanna EmgÃ¥rd, Hana Kammoun, Bethania GarcÃa-Cassani, Julie ChesnÃ©, Sara M. Parigi, Jean-Marie Jacob, Hung-Wei Cheng, Elza Evren, Srustidhar Das, Paulo Czarnewski, Natalie Sleiers, Felipe Melo-Gonzalez, Egle Kvedaraite, Mattias Svensson, Elke Scandella, Matthew R. Hepworth, Samuel Huber, Burkhard Ludewig, Lucie Peduto, Eduardo J. Villablanca, Henrique Veiga-Fernandes, JoÃ£o P. Pereira, Richard A. Flavell, Tim Willinger Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation published pages: 120-132.e8, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2017.11.020	Immunity 48/1	2019-09-04
2018	Cristina Godinho-Silva, Filipa Cardoso, Henrique Veiga-Fernandes Neuroâ€“Immune Cell Units: A New Paradigm in Physiology published pages: , ISSN: 0732-0582, DOI: 10.1146/annurev-immunol-042718-041812	Annual Review of Immunology 37/1	2019-09-04
2018	Roel G.J. Klein Wolterink, Roksana M. Pirzgalska, Henrique Veiga-Fernandes Neuroendocrine Cells Take Your Breath Away published pages: 9-11, ISSN: 1074-7613, DOI: 10.1016/j.immuni.2018.06.010	Immunity 49/1	2019-09-04
2018	Henrique Veiga-Fernandes, David Artis Neuronalâ€“immune system cross-talk in homeostasis published pages: 1465-1466, ISSN: 0036-8075, DOI: 10.1126/science.aap9598	Science 359/6383	2019-09-04
2019	Julie ChesnÃ©, VÃ¢nia Cardoso, Henrique Veiga-Fernandes Neuro-immune regulation of mucosal physiology published pages: 10-20, ISSN: 1933-0219, DOI: 10.1038/s41385-018-0063-y	Mucosal Immunology 12/1	2019-09-04

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