ENAMULATE
Biomimetic mineralization for enamel regeneration
Total Cost €
0EC-Contrib. €
0Partnership
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0ENAMULATE project word cloud
Explore the words cloud of the ENAMULATE project. It provides you a very rough idea of what is the project "ENAMULATE" about.
Project "ENAMULATE" data sheet
The following table provides information about the project.
| Coordinator |
QUEEN MARY UNIVERSITY OF LONDON
Organization address contact info |
| Coordinator Country | United Kingdom [UK] |
| Total cost | 149˙728 € |
| EC max contribution | 149˙728 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-11-01 to 2019-04-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | QUEEN MARY UNIVERSITY OF LONDON | UK (LONDON) | coordinator | 149˙728.00 |
Map
Project objective
Dental enamel has a unique chemical composition and a remarkable well-defined hierarchical structure, which together are responsible for its outstanding properties and critical functionality. Once lost, this tissue cannot be regenerated and is directly involved in a variety of dental problems that affect a large percentage of the world population. This ERC PoC project (ENAMULATE) aims to develop the world’s first human dental enamel regeneration material capable of recreating natural enamel in structure and chemical composition; treating dental defects; and replacing restorative materials currently used in dental clinics. The project builds on findings from the ERC Starting Grant STROFUNSCAFF on the development of an elastin-like protein (ELP) self-assembling process capable of triggering and guiding the hierarchical growth of hydroxyapatite as biocompatible, flexible, and robust coatings in vitro over large uneven areas and directly on human enamel and exposed dentinal tubules. ENAMULATE will optimize the crosslinking mechanism to facilitate its clinical use in the operating room, confirm its efficiency in vitro, and validate its performance in an established animal model. The project will also focus on setting up and moving forward a path towards commercialization by consolidating the intellectual property, investigating the industrial viability, and identifying potential markets.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Sherif Elsharkawy, Maisoon Al-Jawad, Maria F. Pantano, Esther Tejeda-Montes, Khushbu Mehta, Hasan Jamal, Shweta Agarwal, Kseniya Shuturminska, Alistair Rice, Nadezda V. Tarakina, Rory M. Wilson, Andy J. Bushby, Matilde Alonso, Jose C. Rodriguez-Cabello, Ettore Barbieri, Armando del RÃo Hernández, Molly M. Stevens, Nicola M. Pugno, Paul Anderson, Alvaro Mata Protein disorder–order interplay to guide the growth of hierarchical mineralized structures published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-04319-0 |
Nature Communications 9/1 | 2019-11-06 |
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