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EPIC-XS SIGNED

European Proteomics Infrastructure Consortium providing Access

Total Cost €

EC-Contrib. €

Partnership

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EPIC-XS project word cloud

Explore the words cloud of the EPIC-XS project. It provides you a very rough idea of what is the project "EPIC-XS" about.

supporting revolutionary simultaneously materials record computational entirely oriented match mass biotechnology xs perspectives excellence excellent demands days promise consists functions medicine molecular review bottlenecks omics questions technologies clinical track 2400 structural personalized integration life precision extremely mal genomics edge international world shared brings implementing innovative transnational 150 efforts disease independent class shape food panel programs facility proteomic translational proteomics health infrastructure joint bioinformatics agriculture members expertise epic corresponding innovation biological unrivalled cutting spectrometry sciences organization meets facilities proteome mechanisms

Project "EPIC-XS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Netherlands [NL]
Total cost	9˙986˙185 €
EC max contribution	9˙986˙185 € (100%)
Programme	1. H2020-EU.1.4.1.2. (Integrating and opening existing national and regional research infrastructures of European interest)
Code Call	H2020-INFRAIA-2018-1
Funding Scheme	RIA
Starting year	2019
Duration (year-month-day)	from 2019-01-01 to 2022-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITEIT UTRECHT UNIVERSITEIT UTRECHT Organization address address: HEIDELBERGLAAN 8 city: UTRECHT postcode: 3584 CS website: www.uu.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	coordinator	1˙745˙000.00
2	VIB VZW VIB VZW Organization address address: RIJVISSCHESTRAAT 120 city: ZWIJNAARDE - GENT postcode: 9052 website: www.vib.be contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	BE (ZWIJNAARDE - GENT)	participant	1˙351˙127.00
3	KOBENHAVNS UNIVERSITET KOBENHAVNS UNIVERSITET Organization address address: NORREGADE 10 city: KOBENHAVN postcode: 1165 website: www.ku.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (KOBENHAVN)	participant	1˙206˙963.00
4	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	participant	1˙202˙916.00
5	TECHNISCHE UNIVERSITAET MUENCHEN TECHNISCHE UNIVERSITAET MUENCHEN Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 website: www.tu-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	524˙202.00
6	FUNDACIO CENTRE DE REGULACIO GENOMICA FUNDACIO CENTRE DE REGULACIO GENOMICA Organization address address: CARRER DOCTOR AIGUADER 88 city: BARCELONA postcode: 8003 website: www.crg.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	523˙349.00
7	INSTITUT PASTEUR INSTITUT PASTEUR Organization address address: RUE DU DOCTEUR ROUX 25-28 city: PARIS CEDEX 15 postcode: 75724 website: http://www.pasteur.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS CEDEX 15)	participant	499˙282.00
8	ISTITUTO EUROPEO DI ONCOLOGIA SRL ISTITUTO EUROPEO DI ONCOLOGIA SRL Organization address address: Via Filodrammatici 10 city: MILANO postcode: 20121 website: www.ieo.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	participant	488˙125.00
9	FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III FUNDACION CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS CARLOS III Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 website: www.cnio.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	480˙782.00
10	MIKROBIOLOGICKY USTAV AV CR V.V.I MIKROBIOLOGICKY USTAV AV CR V.V.I Organization address address: VIDENSKA 1083 city: PRAHA 4 postcode: 142 00 website: http://www.biomed.cas.cz/mbu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CZ (PRAHA 4)	participant	474˙125.00
11	KUNGLIGA TEKNISKA HOEGSKOLAN KUNGLIGA TEKNISKA HOEGSKOLAN Organization address address: BRINELLVAGEN 8 city: STOCKHOLM postcode: 100 44 website: www.kth.se contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	SE (STOCKHOLM)	participant	473˙312.00
12	EUROPEAN MOLECULAR BIOLOGY LABORATORY EUROPEAN MOLECULAR BIOLOGY LABORATORY Organization address address: Meyerhofstrasse 1 city: HEIDELBERG postcode: 69117 website: http://www.embl.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HEIDELBERG)	participant	266˙750.00
13	EBERHARD KARLS UNIVERSITAET TUEBINGEN EBERHARD KARLS UNIVERSITAET TUEBINGEN Organization address address: GESCHWISTER-SCHOLL-PLATZ city: TUEBINGEN postcode: 72074 website: www.uni-tuebingen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (TUEBINGEN)	participant	209˙750.00
14	FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH FORSCHUNGSINSTITUT FUR MOLEKULARE PATHOLOGIE GESELLSCHAFT MBH Organization address address: CAMPUS-VIENNA-BIOCENTER 1 city: WIEN postcode: 1030 website: www.imp.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	208˙500.00
15	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	120˙500.00
16	IDRYMA TECHNOLOGIAS KAI EREVNAS IDRYMA TECHNOLOGIAS KAI EREVNAS Organization address address: N PLASTIRA STR 100 city: IRAKLEIO postcode: 70013 website: www.forth.gr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EL (IRAKLEIO)	participant	70˙500.00
17	TARTU ULIKOOL TARTU ULIKOOL Organization address address: ULIKOOLI 18 city: TARTU postcode: 51005 website: www.ut.ee contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	EE (TARTU)	participant	70˙500.00
18	UNIVERSITETET I BERGEN UNIVERSITETET I BERGEN Organization address address: MUSEPLASSEN 1 city: BERGEN postcode: 5020 website: www.uib.no contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NO (BERGEN)	participant	70˙500.00

Map

Project objective

In life sciences research, proteomics technologies promise to be even more revolutionary than genomics for understanding the molecular mechanisms of complex biological systems and their (mal-)functions in health and disease. As a result, there is a strongly growing need for the integration of proteomic technologies into world-class life sciences research programs in medicine, agriculture, food, biotechnology, and materials.

The European Proteomics Infrastructure Consortium providing Access (EPIC-XS) brings together a consortium of world-leading, highly innovative European proteomics facilities with the shared goal of supporting excellent life sciences research in Europe. This will be achieved by providing access to cutting-edge proteomics facilities, and by developing and implementing novel mass spectrometry based proteomics and bioinformatics approaches to shape the future life sciences research in Europe.

The Transnational Access in EPIC-XS consists of around 2400 days of access to state-of-the-art proteomics facilities, corresponding to around 150 user projects, which will be evaluated by an independent review panel to ensure excellence, and to match users with the best facility for their challenging research questions.

The cutting-edge Joint Research Activities in EPIC-XS are built on the extremely strong innovation track record of the consortium members, and will address bottlenecks in, and develop novel approaches for, future-oriented efforts in computational and structural proteomics, analysis of higher-order proteome organization, multi-omics integration, and translational/clinical proteomics and personalized/precision medicine.

EPIC-XS will provide users with unrivalled access to world-leading facilities and expertise, while simultaneously extending Europe’s leading international role in the. EPIC-XS meets the widespread current demands for user access, addresses present bottlenecks in the field and will open up entirely new perspectives in proteomics.

Publications

List of publications.
year	authors and title	journal	last update
2020	Julianus Pfeuffer, Timo Sachsenberg, Tjeerd M. H. Dijkstra, Oliver Serang, Knut Reinert, Oliver Kohlbacher EPIFANY: A Method for Efficient High-Confidence Protein Inference published pages: , ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.9b00566	Journal of Proteome Research	2020-03-05
2020	Oleg Klykov, Carmen van der Zwaan, Albert J. R. Heck, Alexander B. Meijer, Richard A. Scheltema Missing regions within the molecular architecture of human fibrin clots structurally resolved by XL-MS and integrative structural modeling published pages: 1976-1987, ISSN: 0027-8424, DOI: 10.1073/pnas.1911785117	Proceedings of the National Academy of Sciences 117/4	2020-03-05
2019	Roberta Noberini, Camilla Restellini, Evelyn Oliva Savoia, Tiziana Bonaldi Enrichment of histones from patient samples for mass spectrometry-based analysis of post-translational modifications published pages: , ISSN: 1046-2023, DOI: 10.1016/j.ymeth.2019.10.001	Methods	2020-03-05
2020	Saar A. M. Laarse, Charlotte A. G. H. Gelder, Marshall Bern, Michiel Akeroyd, Maurien M. A. Olsthoorn, Albert J. R. Heck Targeting proline in (phospho)proteomics published pages: , ISSN: 1742-464X, DOI: 10.1111/febs.15190	The FEBS Journal	2020-03-05
2019	Alicia Lundby, Giulia Franciosa, Kristina B. Emdal, Jan C. Refsgaard, Sebastian P. Gnosa, Dorte B. Bekker-Jensen, Anna Secher, Svetlana R. Maurya, Indranil Paul, Blanca L. Mendez, Christian D. Kelstrup, Chiara Francavilla, Marie Kveiborg, Guillermo Montoya, Lars J. Jensen, Jesper V. Olsen Oncogenic Mutations Rewire Signaling Pathways by Switching Protein Recruitment to Phosphotyrosine Sites published pages: 543-560.e26, ISSN: 0092-8674, DOI: 10.1016/j.cell.2019.09.008	Cell 179/2	2020-03-05
2019	Niels Hulstaert, Jim Shofstahl, Timo Sachsenberg, Mathias Walzer, Harald Barsnes, Lennart Martens, Yasset Perez-Riverol ThermoRawFileParser: Modular, Scalable, and Cross-Platform RAW File Conversion published pages: 537-542, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.9b00328	Journal of Proteome Research 19/1	2020-03-05
2020	Dorte B. Bekker-Jensen, Oliver M. Bernhardt, Alexander Hogrebe, Ana Martinez-Val, Lynn Verbeke, Tejas Gandhi, Christian D. Kelstrup, Lukas Reiter, Jesper V. Olsen Rapid and site-specific deep phosphoproteome profiling by data-independent acquisition without the need for spectral libraries published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-020-14609-1	Nature Communications 11/1	2020-03-05
2020	Juan Antonio VizcaÃno, Peter Kubiniok, Kevin A. Kovalchik, Qing Ma, JÃ©rÃ´me D. Duquette, Ian Mongrain, Eric W. Deutsch, Bjoern Peters, Alessandro Sette, Isabelle Sirois, Etienne Caron The Human Immunopeptidome Project: A Roadmap to Predict and Treat Immune Diseases published pages: 31-49, ISSN: 1535-9476, DOI: 10.1074/mcp.r119.001743	Molecular & Cellular Proteomics 19/1	2020-03-05
2019	Ralf Gabriels, Lennart Martens, Sven Degroeve Updated MSÂ²PIP web server delivers fast and accurate MSÂ² peak intensity prediction for multiple fragmentation methods, instruments and labeling techniques published pages: W295-W299, ISSN: 0305-1048, DOI: 10.1093/nar/gkz299	Nucleic Acids Research 47/W1	2020-01-29
2019	Barbara Steigenberger, Roland J. Pieters, Albert J. R. Heck, Richard A. Scheltema PhoX: An IMAC-Enrichable Cross-Linking Reagent published pages: 1514-1522, ISSN: 2374-7943, DOI: 10.1021/acscentsci.9b00416	ACS Central Science 5/9	2020-01-29
2019	Jakub Zeman, Yuzuru Itoh, ZdenÄ›k KukaÄka, Michal RosÅ¯lek, Daniel Kavan, TomÃ¡Å¡ Kouba, Myrte E Jansen, Mahabub P Mohammad, Petr NovÃ¡k, LeoÅ¡ S ValÃ¡Å¡ek Binding of eIF3 in complex with eIF5 and eIF1 to the 40S ribosomal subunit is accompanied by dramatic structural changes published pages: 8282-8300, ISSN: 0305-1048, DOI: 10.1093/nar/gkz570	Nucleic Acids Research 47/15	2020-01-29
2019	Erin K. Zess, Cassandra Jensen, Neftaly Cruz-Mireles, Juan Carlos De la Concepcion, Jan Sklenar, Madlen Stephani, Richard Imre, Elisabeth Roitinger, Richard Hughes, Khaoula Belhaj, Karl Mechtler, Frank L. H. Menke, Tolga Bozkurt, Mark J. Banfield, Sophien Kamoun, Abbas Maqbool, Yasin F. Dagdas N-terminal Î²-strand underpins biochemical specialization of an ATG8 isoform published pages: e3000373, ISSN: 1545-7885, DOI: 10.1371/journal.pbio.3000373	PLOS Biology 17/7	2020-01-29
2018	Clement M. Potel, Simone Lemeer, Albert J. R. Heck Phosphopeptide Fragmentation and Site Localization by Mass Spectrometry: An Update published pages: 126-141, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b04746	Analytical Chemistry 91/1	2020-01-29
2019	Slavata, ChmelÃk, Kavan, FilandrovÃ¡, Fiala, RosÅ¯lek, MrÃ¡zek, KukaÄka, ValiÅ¡, Man, Miller, McIntyre, Fabris, NovÃ¡k MS-Based Approaches Enable the Structural Characterization of Transcription Factor/DNA Response Element Complex published pages: 535, ISSN: 2218-273X, DOI: 10.3390/biom9100535	Biomolecules 9/10	2020-01-29
2019	Yasset Perez-Riverol, Andrey Zorin, Gaurhari Dass, Manh-Tu Vu, Pan Xu, Mihai Glont, Juan Antonio VizcaÃno, Andrew F. Jarnuczak, Robert Petryszak, Peipei Ping, Henning Hermjakob Quantifying the impact of public omics data published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-019-11461-w	Nature Communications 10/1	2020-01-29
2019	Johann Holzmann, Antonio Z Politi, Kota Nagasaka, Merle Hantsche-Grininger, Nike Walther, Birgit Koch, Johannes Fuchs, Gerhard DÃ¼rnberger, Wen Tang, Rene Ladurner, Roman R Stocsits, Georg A Busslinger, BÃ©la NovÃ¡k, Karl Mechtler, Iain Finley Davidson, Jan Ellenberg, Jan-Michael Peters Absolute quantification of cohesin, CTCF and their regulators in human cells published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.46269	eLife 8	2020-01-29
2019	Cristina Chiva, Olga Pastor, LucÃa Trilla-Fuertes, Angelo GÃ¡mez-Pozo, Juan Ãngel Fresno Vara, Eduard SabidÃ³ Isotopologue Multipoint Calibration for Proteomics Biomarker Quantification in Clinical Practice published pages: 4934-4938, ISSN: 0003-2700, DOI: 10.1021/acs.analchem.8b05802	Analytical Chemistry 91/8	2020-01-29
2019	Sem Tamara, Max Hoek, Richard A. Scheltema, Aneika C. Leney, Albert J.R. Heck A Colorful Pallet of B-Phycoerythrin Proteoforms Exposed by a Multimodal Mass Spectrometry Approach published pages: 1302-1317, ISSN: 2451-9294, DOI: 10.1016/j.chempr.2019.03.006	Chem 5/5	2020-01-29
2019	Rosulek, Darebna, Pompach, Slavata, Novak Proteases Immobilization for In Situ Time-Limited Proteolysis on MALDI Chips published pages: 833, ISSN: 2073-4344, DOI: 10.3390/catal9100833	Catalysts 9/10	2020-01-29
2019	Rosulek, Darebna, Pompach, Slavata, Novak Proteases Immobilization for In Situ Time-Limited Proteolysis on MALDI Chips published pages: 833, ISSN: 2073-4344, DOI: 10.3390/catal9100833	Catalysts 9/10	2020-01-29
2018	Sebastiaan C. de Graaf, Oleg Klykov, Henk van den Toorn, Richard A. Scheltema Cross-ID: Analysis and Visualization of Complex XLâ€“MS-Driven Protein Interaction Networks published pages: 642-651, ISSN: 1535-3893, DOI: 10.1021/acs.jproteome.8b00725	Journal of Proteome Research 18/2	2019-09-04

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