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MNSWLGM SIGNED

An optofluidic platform based on liquid-gradient refractive index microlens for the isolation and quantification of extracellular vesicles

Total Cost €

EC-Contrib. €

Partnership

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MNSWLGM project word cloud

Explore the words cloud of the MNSWLGM project. It provides you a very rough idea of what is the project "MNSWLGM" about.

biomarkers prognosis actively put whilst mu microlens incorporate refractive passively platform constructed polarizability optical purification diagnosis interaction efficient index single strength cells diseases criterion manipulate reconfigurable populations viscoelastic bottleneck invasive simply microvesicles samples isolation imaging secreted selective biological optofluidic identification quantitation followed grin separation nm ev fractionation technological particle therapy enrichment nanoparticle 500 extracellular lattice small sorting dynamically size module matrices characterization gradient evs immensely 200 vesicles describe liquid

Project "MNSWLGM" data sheet

The following table provides information about the project.

Coordinator	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	187˙419 €
EC max contribution	187˙419 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2017
Funding Scheme	MSCA-IF-EF-ST
Starting year	2019
Duration (year-month-day)	from 2019-08-01 to 2021-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH Organization address address: Raemistrasse 101 city: ZUERICH postcode: 8092 website: https://www.ethz.ch/de.html contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (ZUERICH)	coordinator	187˙419.00

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Project objective

Extracellular vesicles (EVs) describe distinct populations of small (30-200 nm) and large (500 nm-2 μm) microvesicles actively or passively secreted by cells. Whilst, they are recognized as promising biomarkers for diseases diagnosis, prognosis and therapy, their purification, selective enrichment, and characterization remains immensely challenging. The goal of the current proposal is to develop an optofluidic platform able to manipulate and characterize single EVs and facilitate their efficient purification and quantitation from biological samples. The optofluidic platform will incorporate a dynamically reconfigurable optical lattice (constructed from a liquid gradient refractive index - L-GRIN microlens) for separation followed by a viscoelastic focusing module for single EV imaging. The strength of the interaction between a nanoparticle and the optical lattice will depend on the optical polarizability of the particle, thus providing a size selection criterion to allow identification and isolation. Put simply, we aim to develop a size-selective optofluidic platform integrated for non-invasive EVs sorting and fractionation that can be applied to a wide range of biological matrices and addresses the most challenging technological bottleneck in EVs research.

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The information about "MNSWLGM" are provided by the European Opendata Portal: CORDIS opendata.