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Mi-DOG SIGNED

The “parasitism-readers” of the world’s most damaging plant-parasitic nematode Meloidogyne incognita: new avenues to address food global security.

Total Cost €

EC-Contrib. €

Partnership

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Mi-DOG project word cloud

Explore the words cloud of the Mi-DOG project. It provides you a very rough idea of what is the project "Mi-DOG" about.

food proteomic pattern expressed box dog protein economically career disease proteins combination group promoter dna delivered describes controls expression thousands coding functional successfully infection spatio parasitic enriched species expertise knot probably link genes area innovative translational meloidogyne my nematode ultimately considerable scientific understand dorsal constraint plant infect motif discovery incognita named reader mi class levels root host secreted builds regions promise secondly world security approximately worldwide gland damaging readers connection mediated temporal molecular firstly parasitism crispr effector coordinates regulation ideas worms orchestrates formal nematodes leads

Project "Mi-DOG" data sheet

The following table provides information about the project.

Coordinator	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Total cost	319˙400 €
EC max contribution	319˙400 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2018
Funding Scheme	MSCA-IF-EF-CAR
Starting year	2020
Duration (year-month-day)	from 2020-04-01 to 2023-03-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	coordinator	319˙400.00

Map

Project objective

My proposal aims to understand how root-knot nematodes cause disease in the host plant.

Understanding how these parasitic worms cause disease is important because they have a worldwide distribution, they infect thousands of different plant species, and ultimately they represent a major constraint on achieving food security in Europe and beyond.

In this proposal I will link my expertise in root-knot nematodes at molecular and proteomic levels, with the host group expertise in the regulation of parasitism genes, to understand how the most economically damaging root-knot nematode Meloidogyne incognita successfully controls the process of plant-parasitism.

My proposal builds on the recent discovery of a non-coding DNA motif that is specifically enriched in the promoter regions of approximately 100 genes expressed in the root-knot Meloidogyne incognita dorsal gland (named Mi-DOG box). This discovery leads to two important ideas: Firstly, given that many effector proteins produced in this gland are delivered into the plant during infection, the Mi-DOG promoter is probably involved in the regulation of parasitism. Secondly, being a non-coding DNA motif, the Mi-DOG box is probably recognized by an associated protein or protein complex, a “reader” that coordinates the expression of secreted parasitism proteins, and ultimately orchestrates the process of plant parasitism.

In a formal connection between two world-class research institutions, the main objectives of my proposal are therefore to: 1) Identify the “readers” of Mi-DOG box using a combination of well-established and highly-innovative CRISPR-mediated methodologies, and 2) characterize the spatio-temporal expression pattern and functional role of these “readers” in M. incognita parasitism.

Overall, my proposal describes a novel scientific approach to address an emerging area of great promise with considerable translational potential, and ultimately to open up my best career opportunities for the future.

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The information about "MI-DOG" are provided by the European Opendata Portal: CORDIS opendata.