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EXIMIOUS SIGNED

Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome

Total Cost €

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EC-Contrib. €

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Partnership

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 EXIMIOUS project word cloud

Explore the words cloud of the EXIMIOUS project. It provides you a very rough idea of what is the project "EXIMIOUS" about.

person    fingerprints    clinical    medicine    reduce    reflect    innovative    remedia    preventive    makers    starting    eximious    policy    multiple    tools    healthcare    ephor    construct    population    bhc    quantifying    predictors    epidemiology    lifespan    hygiene    clinicians    autoimmune    plays    bioinformatics    middle    characterizing    sensor    grasp    longitools    heap    economic    extensively    environmental    prenatal    poor    2018    immunophenotyping    platforms    allergic    toxicology    prioritized    individual    public    life    exposures    pivotal    disorders    entire    health    individuals    socio    communicable    expanse    wellbeing    cohorts    combined    holistic    diseases    disease    prevalence    learning    assessing    ways    asthma    exposomics    populations    sc1    map    linking    gathering    integrate    rising    signs    containing    immune    data    meet    components    hedimed    interaction    datasets    athlete    exposome    dimensional    immunology    lifetime    immunome    multifaceted    human    chronic    profiling    machine    societal    policies    experts    synergy    huge    2020    toolbox    mediated    equal    socioeconomic    omics    immunomics   

Project "EXIMIOUS" data sheet

The following table provides information about the project.

Coordinator
KATHOLIEKE UNIVERSITEIT LEUVEN 

Organization address
address: OUDE MARKT 13
city: LEUVEN
postcode: 3000
website: www.kuleuven.be

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Belgium [BE]
 Total cost 10˙878˙331 €
 EC max contribution 10˙878˙331 € (100%)
 Programme 1. H2020-EU.3.1.2. (Preventing disease)
 Code Call H2020-SC1-2019-Single-Stage-RTD
 Funding Scheme RIA
 Starting year 2020
 Duration (year-month-day) from 2020-01-01   to  2024-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    KATHOLIEKE UNIVERSITEIT LEUVEN BE (LEUVEN) coordinator 4˙130˙715.00
2    FOLKEHELSEINSTITUTTET NO (OSLO) participant 1˙336˙685.00
3    BELGIAN CENTER FOR OCCUPATIONAL HYGIENE BE (GENT) participant 911˙271.00
4    "UNIVERSITATEA DE MEDICINA, FARMACIE, STIINTE SI TEHNOLOGIE ""GEORGE EMIL PALADE"" DIN TARGU MURES" RO (TARGU MURES) participant 771˙437.00
5    DET NATIONALE FORSKNINGSCENTER FORARBEJDSMILJO DK (KOBENHAVN) participant 664˙875.00
6    UNIVERSITEIT HASSELT BE (HASSELT) participant 600˙725.00
7    UNIVERSITE CATHOLIQUE DE LOUVAIN BE (LOUVAIN LA NEUVE) participant 549˙500.00
8    INTERUNIVERSITAIR MICRO-ELECTRONICA CENTRUM BE (LEUVEN) participant 461˙025.00
9    FUNDACIO HOSPITAL UNIVERSITARI VALL D'HEBRON - INSTITUT DE RECERCA ES (BARCELONA) participant 395˙500.00
10    THE BABRAHAM INSTITUTE UK (CAMBRIDGE) participant 256˙250.00
11    ACCELOPMENT AG CH (ZUERICH) participant 221˙890.00
12    BIOGENITY ApS DK (AALBORG) participant 180˙850.00
13    REGION HOVEDSTADEN DK (HILLEROD) participant 172˙000.00
14    THE QUEEN'S UNIVERSITY OF BELFAST UK (BELFAST) participant 158˙457.00
15    AARHUS UNIVERSITET DK (AARHUS C) participant 67˙150.00

Map

 Project objective

Immune-mediated, non-communicable diseases, such as autoimmune diseases, allergic diseases and asthma, are chronic disorders in which the interaction between exposome and immune system plays a pivotal role. As prevalence and societal costs of these diseases are rising in the EU, a holistic approach is needed. The EXIMIOUS consortium—gathering high-level experts in immunology, toxicology, clinical medicine, environmental hygiene, epidemiology, bioinformatics and sensor development—will bring about a new way of assessing the human exposome by linking innovative ways of characterizing and quantifying multiple and combined environmental exposures (exposomics) with high-dimensional immunophenotyping and -profiling platforms to map the (early) immune effects induced by these exposures (immunomics). In several cohorts—covering the entire lifespan, including prenatal life—we will extensively map exposome, immune system (immunome), other omics and clinical and socio-economic data, using two main methodologies—one starting from the exposome, the other starting from health effects—that ‘meet in the middle’. Novel bioinformatics tools, based on systems immunology and machine learning, will be used to integrate and analyse these huge datasets and to construct ‘immune fingerprints’ that reflect a person’s lifetime exposome and identify ‘immune fingerprints’ that are early signs of poor health and predictors of disease at the individual level. We will build a multifaceted toolbox for researchers, policy makers, clinicians and the general public containing the exposome/immunome tools developed during the project to help assess the impact of the exposome on the immune system at the level of individuals and populations. This will allow policy makers to grasp the components of the exposome that needs to be prioritized to be able to design targeted preventive policies to reduce healthcare and socioeconomic costs, leading to greater wellbeing for the EU population. EXIMIOUS will work together with the other projects (EXPANSE, HEAP, ATHLETE, EQUAL-LIFE, LONGITOOLS, EPHOR, REMEDIA and HEDIMED) funded within the Human Exposome programme call H2020-SC1-BHC-2018-2020, in order to achieve collaboration and synergy.

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The information about "EXIMIOUS" are provided by the European Opendata Portal: CORDIS opendata.

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HEAP (2020)

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EXIMIOUS (2020)

Mapping Exposure-Induced Immune Effects: Connecting the Exposome and the Immunome

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