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ISOLDA SIGNED

Improved Vaccination Strategies for Older Adults

Total Cost €

EC-Contrib. €

Partnership

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ISOLDA project word cloud

Explore the words cloud of the ISOLDA project. It provides you a very rough idea of what is the project "ISOLDA" about.

solutions 65 restore mva vivo highest immunological models adult ex compound borne syndrome immunology animal immunomodulator pbmc infections seasonal builds formulations inflammageing innovative influenza immunosenescent licenced trial applicability immune group east yellow safety restoring cohorts efficacy replicons adults respiratory kinase vaccination encephalitis proof replication vaccines competent uniquely middle tick human tiered inhibitors cell population 14 expertise signatures isolda immunomodulators onco interdisciplinary 2019 age viral tested bhc ageing shown generation sc1 burdens propagation virology mers virus added preventive vaccinees fever broad deficient compounds older vaccine immunosenescence modulators diseases patients clinical

Project "ISOLDA" data sheet

The following table provides information about the project.

Coordinator	STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER Organization address address: BUNTEWEG 2 city: HANNOVER postcode: 30559 website: www.tiho-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Total cost	6˙087˙314 €
EC max contribution	6˙087˙314 € (100%)
Programme	1. H2020-EU.3.1.3. (Treating and managing disease)
Code Call	H2020-SC1-2019-Two-Stage-RTD
Funding Scheme	RIA
Starting year	2020
Duration (year-month-day)	from 2020-01-01 to 2024-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER STIFTUNG TIERAERZTLICHE HOCHSCHULE HANNOVER Organization address address: BUNTEWEG 2 city: HANNOVER postcode: 30559 website: www.tiho-hannover.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HANNOVER)	coordinator	1˙709˙375.00
2	CURVE CLINICAL BV CURVE CLINICAL BV Organization address address: JOOP GEESINKWEG 701 2E ETAGE city: AMSTERDAM DUIVENDRECHT postcode: 1114 AB website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (AMSTERDAM DUIVENDRECHT)	participant	1˙751˙713.00
3	AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS AGENCIA ESTATAL CONSEJO SUPERIOR DEINVESTIGACIONES CIENTIFICAS Organization address address: CALLE SERRANO 117 city: MADRID postcode: 28006 website: http://www.csic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	participant	775˙000.00
4	BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN BERNHARD-NOCHT-INSTITUT FUER TROPENMEDIZIN Organization address address: BERNHARD NOCHT STRASSE 74 city: HAMBURG postcode: 20359 website: www.bni.uni-hamburg.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (HAMBURG)	participant	650˙548.00
5	FUNDACION PUBLICA MIGUEL SERVET FUNDACION PUBLICA MIGUEL SERVET Organization address address: CALLE IRUNLARREA 3 CENTRO INVESTIGACION BIOMEDICA RECINTO COMPLEJO HOSPITALARIO DE NAVARRA city: PAMPLONA postcode: 31008 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (PAMPLONA)	participant	500˙000.00
6	ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM Organization address address: DR MOLEWATERPLEIN 40 city: ROTTERDAM postcode: 3015 GD website: www.erasmusmc.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (ROTTERDAM)	participant	400˙000.00
7	UNIVERSITA DEGLI STUDI DI PALERMO UNIVERSITA DEGLI STUDI DI PALERMO Organization address address: PIAZZA MARINA 61 city: PALERMO postcode: 90133 website: http://www.unipa.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (PALERMO)	participant	300˙677.00

Map

Project objective

ISOLDA aims at the development of improved vaccines for older adults against viral diseases with highest burdens at old age, by promoting virus-specific T cell responses in vaccinees over 65 years, using modulators of T cell immunosenescence and inflammageing. It builds on leading interdisciplinary expertise and knowledge of ISOLDA partners in virology, (onco-)immunology, ageing and immunosenescence, to assess the potential of immunomodulators, including kinase inhibitors licenced for other human use, to improve vaccine-induced immune responses and safety in older adults. ISOLDA partners have shown that these compounds may indeed restore key immunosenescent signatures. They will investigate ex-vivo signatures of immunological ageing and restoring potential of selected compounds on vaccine-induced immune responses against influenza virus, using PBMC from past and on-going adult and ageing human cohorts of influenza vaccinees. Cohorts of vaccinees and/or patients for tick-borne encephalitis, Middle-East respiratory syndrome and yellow fever are also uniquely available to ISOLDA to demonstrate broad applicability of the approach. The most promising compounds will be tested in in-vivo animal models for vaccination against these diseases. As a clinical proof of concept, ISOLDA will aim at improving efficacy of current seasonal influenza vaccines up to a tiered phase I clinical trial with a lead immunomodulator compound selected from the ex vivo and in vivo studies, that will be added to current vaccine formulations. ISOLDA will further build on new generation vaccines against MERS, such as replication-competent propagation-deficient replicons and MVA-MERS S recently developed by ISOLDA partners. Taken together, ISOLDA will address call SC1-BHC-14-2019, by providing innovative solutions to reduced efficacy and safety of preventive vaccines in the increasing population of older adults, against viral infections that have the highest impact in this age group.

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