HEARTOFSTROKE SIGNED
The heart of stroke: Pipes, Perfusion, Parenchyma
Total Cost €
0EC-Contrib. €
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Project "HEARTOFSTROKE" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITAIR MEDISCH CENTRUM UTRECHT
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 1˙499˙450 € |
| EC max contribution | 1˙499˙450 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-STG |
| Funding Scheme | ERC-STG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-03-01 to 2020-02-29 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITAIR MEDISCH CENTRUM UTRECHT | NL (UTRECHT) | coordinator | 1˙499˙450.00 |
Map
Project objective
My aim is to understand the cause of stroke in every single patient. Brain microinfarcts and macroinfarcts cause a major healthcare burden in Western societies both in terms of morbidity and costs. Cardiovascular thromboemboli from the heart, aorta and neck arteries are considered as the main cause. Still, the vast majority of brain infarcts are unexplained. In contrast to the thromboembolic explanation for brain infarcts, heart infarcts are known to be caused by local atherosclerotic plaque of the coronary arteries and impaired perfusion. This has led to successful preventive and therapeutic strategies against myocardial infarction. For brain infarcts, a blind eye is turned to local atherosclerotic plaque in the intracranial vasculature (Pipes) and impaired Perfusion as possible causes of macro and microinfarcts (Parenchyma). For the ‘3Ps’ (Pipes, Perfusion, Parenchyma) I have created new research fields based on innovative noninvasive arterial spin labeling perfusion MRI, perfusion reserve, perfusion territory and vessel wall MRI methods. In this project, I will go an important step beyond the state of the art by investigating the total intracranial burden of disease of these ‘3Ps’ and systematic evaluations in patients. Pipes: novel methods to visualise and characterise intracranial plaque including inflammatory plaque enhancement, intraplaque haemorrhage and calcification detection. Perfusion: novel methods to investigate hemodynamic impairment in areas with critically low perfusion with noninvasive arterial spin labeling MRI methods and perfusion reserve methods specific for each intracranial perfusion territory. Parenchyma: novel methods to detect microinfarcts. Technical innovations (Pipes, Perfusion) will be applied in synergy to explain micro and macroinfarcts (Parenchyma). Patient specific biomarkers will, similar to the heart, pave the way for designing preventive and therapeutic strategies aimed at reducing the burden of neurodegenerative diseases.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2019 |
M.H.T. Zwartbol, M.I. Geerlings, R. Ghaznawi, J. Hendrikse, A.G. van der Kolk Intracranial Atherosclerotic Burden on 7T MRI Is Associated with Markers of Extracranial Atherosclerosis: The SMART-MR Study published pages: , ISSN: 0195-6108, DOI: 10.3174/ajnr.a6308 |
American Journal of Neuroradiology | 2020-04-15 |
| 2020 |
Lisa A. van der Kleij, Jill B. De Vis, Jeroen de Bresser, Jeroen Hendrikse, Jeroen C. W. Siero Arterial CO2 pressure changes during hypercapnia are associated with changes in brain parenchymal volume published pages: , ISSN: 2509-9280, DOI: 10.1186/s41747-020-0144-z |
European Radiology Experimental 4/1 | 2020-04-15 |
| 2020 |
Arjen Lindenholz, Anja G. van der Kolk, Irene C. van der Schaaf, H. Bart van der Worp, Anita A. Harteveld, Nikki Dieleman, Michiel L. Bots, Jeroen Hendrikse Intracranial Atherosclerosis Assessed with 7-T MRI: Evaluation of Patients with Ischemic Stroke or Transient Ischemic Attack published pages: 162-170, ISSN: 0033-8419, DOI: 10.1148/radiol.2020190643 |
Radiology 295/1 | 2020-04-15 |
| 2016 |
Nikki Dieleman, Wenjie Yang, Jill M. Abrigo, Winnie Chiu Wing Chu, Anja G. van der Kolk, Jeroen C.W. Siero, Ka Sing Wong, Jeroen Hendrikse, Xiang Yan Chen Magnetic Resonance Imaging of Plaque Morphology, Burden, and Distribution in Patients With Symptomatic Middle Cerebral Artery Stenosis published pages: 1797-1802, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.116.013007 |
Stroke 47/7 | 2019-05-27 |
| 2016 |
Nikki Dieleman, Wenjie Yang, Anja G. van der Kolk, Jill Abrigo, Ka Lok Lee, Winnie Chiu Wing Chu, Jaco J. M. Zwanenburg, Jeroen C. W. Siero, Ka Sing Wong, Jeroen Hendrikse, Fiona Xiang Yan Chen Qualitative Evaluation of a High-Resolution 3D Multi-Sequence Intracranial Vessel Wall Protocol at 3 Tesla MRI published pages: e0160781, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0160781 |
PLOS ONE 11/8 | 2019-05-27 |
| 2016 |
Laurens JL De Cocker, Arjen Lindenholz, Jaco JM Zwanenburg, Anja G van der Kolk, Maarten Zwartbol, Peter R Luijten, Jeroen Hendrikse Clinical vascular imaging in the brain at 7T published pages: , ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2016.11.044 |
NeuroImage | 2019-05-27 |
| 2016 |
Thomas Alderliesten, Jill B. De Vis, Petra M.A. Lemmers, Frank van Bel, Manon J.N.L. Benders, Jeroen Hendrikse, Esben T. Petersen T 2 -prepared velocity selective labelling: A novel idea for full-brain mapping of oxygen saturation published pages: 65-73, ISSN: 1053-8119, DOI: 10.1016/j.neuroimage.2016.06.012 |
NeuroImage 139 | 2019-04-25 |
| 2017 |
Anita A. Harteveld, Anja G. van der Kolk, H. Bart van der Worp, Nikki Dieleman, Jaco J.M. Zwanenburg, Peter R. Luijten, Jeroen Hendrikse Detecting Intracranial Vessel Wall Lesions With 7T-Magnetic Resonance Imaging published pages: 2601-2604, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.117.017868 |
Stroke 48/9 | 2019-05-27 |
| 2017 |
Rashid Ghaznawi, Jeroen de Bresser, Yolanda van der Graaf, Maarten HT Zwartbol, Theo D Witkamp, Mirjam I Geerlings, Jeroen Hendrikse Detection and characterization of small infarcts in the caudate nucleus on 7 Tesla MRI: The SMART-MR study published pages: 0271678X1770597, ISSN: 0271-678X, DOI: 10.1177/0271678X17705974 |
Journal of Cerebral Blood Flow & Metabolism | 2019-05-27 |
| 2015 |
Laurens J.L. De Cocker, Raoul P. Kloppenborg, Yolanda van der Graaf, Peter R. Luijten, Jeroen Hendrikse, Mirjam I. Geerlings Cerebellar Cortical Infarct Cavities published pages: STROKEAHA.115.01, ISSN: 0039-2499, DOI: 10.1161/STROKEAHA.115.010093 |
Stroke | 2019-05-27 |
| 2016 |
A. A. Harteveld, N. P. Denswil, J. C. W. Siero, J. J. M. Zwanenburg, A. Vink, B. Pouran, W. G. M. Spliet, D. W. J. Klomp, P. R. Luijten, M. J. Daemen, J. Hendrikse, A. G. van der Kolk Quantitative Intracranial Atherosclerotic Plaque Characterization at 7T MRI: An Ex Vivo Study with Histologic Validation published pages: 802-810, ISSN: 0195-6108, DOI: 10.3174/ajnr.A4628 |
American Journal of Neuroradiology 37/5 | 2019-04-25 |
| 2015 |
A. G. van der Kolk, J. J. M. Zwanenburg, N. P. Denswil, A. Vink, W. G. M. Spliet, M. J. A. P. Daemen, F. Visser, D. W. J. Klomp, P. R. Luijten, J. Hendrikse Imaging the Intracranial Atherosclerotic Vessel Wall Using 7T MRI: Initial Comparison with Histopathology published pages: 694-701, ISSN: 0195-6108, DOI: 10.3174/ajnr.A4178 |
American Journal of Neuroradiology 36/4 | 2019-04-25 |
| 2016 |
Anita A. Harteveld, Anja G. van der Kolk, H. Bart van der Worp, Nikki Dieleman, Jeroen C. W. Siero, Hugo J. Kuijf, Catharina J. M. Frijns, Peter R. Luijten, Jaco J. M. Zwanenburg, Jeroen Hendrikse High-resolution intracranial vessel wall MRI in an elderly asymptomatic population: comparison of 3T and 7T published pages: , ISSN: 0938-7994, DOI: 10.1007/s00330-016-4483-3 |
European Radiology | 2019-05-27 |
| 2016 |
Diederik P.J. Smeeing, Jeroen Hendrikse, Esben T. Petersen, Manus J. Donahue, Jill B. de Vis Arterial Spin Labeling and Blood Oxygen Level-Dependent MRI Cerebrovascular Reactivity in Cerebrovascular Disease: A Systematic Review and Meta-Analysis published pages: 288-307, ISSN: 1015-9770, DOI: 10.1159/000446081 |
Cerebrovascular Diseases 42/3-4 | 2019-05-27 |
| 2017 |
Manus J Donahue, Eric Achten, Petrice M Cogswell, Frank-Erik De Leeuw, Colin P Derdeyn, Rick M Dijkhuizen, Audrey P Fan, Rashid Ghaznawi, Jeremy J Heit, M Arfan Ikram, Peter Jezzard, Lori C Jordan, Eric Jouvent, Linda Knutsson, Richard Leigh, David S Liebeskind, Weili Lin, Thomas W Okell, Adnan I Qureshi, Charlotte J Stagg, Matthias JP van Osch, Peter CM van Zijl, Jennifer M Watchmaker, Max Wintermark, Ona Wu, Greg Zaharchuk, Jinyuan Zhou, Jeroen Hendrikse Consensus statement on current and emerging methods for the diagnosis and evaluation of cerebrovascular disease published pages: 0271678X1772183, ISSN: 0271-678X, DOI: 10.1177/0271678X17721830 |
Journal of Cerebral Blood Flow & Metabolism | 2019-05-27 |
| 2016 |
Nolan S Hartkamp, J Hendrikse, Laurens J L De Cocker, Gert Jan de Borst, L Jaap Kappelle, Reinoud P H Bokkers Misinterpretation of ischaemic infarct location in relationship to the cerebrovascular territories published pages: 1084-1090, ISSN: 0022-3050, DOI: 10.1136/jnnp-2015-312906 |
Journal of Neurology, Neurosurgery & Psychiatry 87/10 | 2019-05-27 |
| 2017 |
Laurens J.L. De Cocker, Karl-Olof Lövblad, Jeroen Hendrikse MRI of Cerebellar Infarction published pages: 137-146, ISSN: 0014-3022, DOI: 10.1159/000455229 |
European Neurology 77/3-4 | 2019-05-27 |
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