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MetDNASecStr SIGNED

Metabolism of DNA secondary structures and their impact on genome stability

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MetDNASecStr project word cloud

Explore the words cloud of the MetDNASecStr project. It provides you a very rough idea of what is the project "MetDNASecStr" about.

cancer obstacles duplication hallmark mammalian enzymatic progeny contributions stabilise direct central aberrations play framework involve hindrance fork poorly telomeric survival humans stress investigation certain secondary abnormalities fragile organismal discover loci mechanisms outstanding genome hard structures telomeres stability visualisation ensures complexes roles propensity molecules despite question sequences repair ribosomal telomere repetitive biological quadruplex proteomics diseases genomic nature cellular replication maintenance loops unclear dna faithful restart decipher sites cell ultimately function plan complementary structure tracts transmission multidisciplinary replicate instability source division

Project "MetDNASecStr" data sheet

The following table provides information about the project.

Coordinator	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://www.imperial.ac.uk/people/j.vannier
Total cost	1˙638˙041 €
EC max contribution	1˙638˙041 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2021-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE IMPERIAL COLLEGE OF SCIENCE TECHNOLOGY AND MEDICINE Organization address address: SOUTH KENSINGTON CAMPUS EXHIBITION ROAD city: LONDON postcode: SW7 2AZ website: http://www.imperial.ac.uk/ contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	1˙638˙041.00

Map

Project objective

DNA replication is an essential process for genome duplication, cell division and ultimately organismal survival that ensures faithful transmission of the genome to progeny. Certain genomic loci represent major obstacles to DNA replication including fragile sites, G-rich tracts and repetitive sequences, such as ribosomal DNA and telomeres. Mammalian telomeres have the propensity to adopt complex DNA secondary structures, including telomere-loops and telomeric G-quadruplex DNA, which are believed to play essential roles in telomere maintenance. However, recent work has established that these structures are also a hindrance to DNA replication and failure to stabilise, repair or restart the replication fork is a potential source of genome instability, the hallmark of many diseases including cancer. Despite recent advances, the mechanisms that facilitate DNA replication at telomeres and other hard to replicate loci throughout the genome remain unclear. This proposal aims to address this important question in order to discover and decipher the mechanisms that help DNA replication through DNA secondary structures. I propose using multidisciplinary approaches to investigate the cellular response to replication stress at telomeres and the enzymatic activities that result in telomere replication aberrations, which will involve direct visualisation of telomere abnormalities using complementary DNA related methodologies and analysis of novel telomere-associated complexes. I also plan to determine the nature/structure of fragile telomeres, which remains poorly defined and represent a central question for the field using visualisation of biological molecules and proteomics. The detailed investigation of the function of known and new factors that facilitate telomere DNA replication represent an outstanding challenge that will provide a novel framework for understanding the contributions of replication factors in general DNA replication, genome stability and cancer in humans.

Publications

List of publications.
year	authors and title	journal	last update
2020	Rosa Maria Porreca, Emilia Herrera-Moyano, Eleni Skourti, Pui Pik Law, Roser Gonzalez Franco, Alex Montoya, Peter Faull, Holger Kramer, Jean-Baptiste Vannier TRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres published pages: , ISSN: 2050-084X, DOI: 10.7554/elife.49817	eLife 9	2020-03-20

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The information about "METDNASECSTR" are provided by the European Opendata Portal: CORDIS opendata.