BIOLOCHANICS SIGNED
Localization in biomechanics and mechanobiology of aneurysms: Towards personalized medicine
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Project "BIOLOCHANICS" data sheet
The following table provides information about the project.
| Coordinator |
ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS
Organization address contact info |
| Coordinator Country | France [FR] |
| Total cost | 1˙999˙396 € |
| EC max contribution | 1˙999˙396 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2014-CoG |
| Funding Scheme | ERC-COG |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-05-01 to 2020-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | ASSOCIATION POUR LA RECHERCHE ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS | FR (PARIS) | coordinator | 1˙920˙003.00 |
| 2 | CENTRE HOSPITALIER UNIVERSITAIRE SAINT ETIENNE - CHU | FR (SAINT ETIENNE) | participant | 79˙393.00 |
Map
Project objective
Rupture of Aortic Aneurysms (AA), which kills more than 30 000 persons every year in Europe and the USA, is a complex phenomenon that occurs when the wall stress exceeds the local strength of the aorta due to degraded properties of the tissue. The state of the art in AA biomechanics and mechanobiology reveals that major scientific challenges still have to be addressed to permit patient-specific computational predictions of AA rupture and enable localized repair of the structure with targeted pharmacologic treatment. A first challenge relates to ensuring an objective prediction of localized mechanisms preceding rupture. A second challenge relates to modelling the patient-specific evolutions of material properties leading to the localized mechanisms preceding rupture. Addressing these challenges is the aim of the BIOLOCHANICS proposal. We will take into account internal length-scales controlling localization mechanisms preceding AA rupture by implementing an enriched, also named nonlocal, continuum damage theory in the computational models of AA biomechanics and mechanobiology. We will also develop very advanced experiments, based on full-field optical measurements, aimed at characterizing localization mechanisms occurring in aortic tissues and at identifying local distributions of material properties at different stages of AA progression. A first in vivo application will be performed on genetic and pharmacological models of mice and rat AA. Eventually, a retrospective clinical study involving more than 100 patients at the Saint-Etienne University hospital will permit calibrating estimations of AA rupture risk thanks to our novel approaches and infuse them into future clinical practice. Through the achievements of BIOLOCHANICS, nonlocal mechanics will be possibly extended to other soft tissues for applications in orthopaedics, oncology, sport biomechanics, interventional surgery, human safety, cell biology, etc.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Witold Krasny, Claire Morin, Hélène Magoariec, Stéphane Avril A comprehensive study of layer-specific morphological changes in the microstructure of carotid arteries under uniaxial load published pages: 342-351, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.04.033 |
Acta Biomaterialia 57 | 2020-03-23 |
| 2016 |
Ambroise Duprey, Olfa Trabelsi, Marco Vola, Jean-Pierre Favre, Stéphane Avril Biaxial rupture properties of ascending thoracic aortic aneurysms published pages: 273-285, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2016.06.028 |
Acta Biomaterialia 42 | 2020-03-23 |
| 2017 |
S. Jamaleddin Mousavi, Stéphane Avril Patient-specific stress analyses in the ascending thoracic aorta using a finite-element implementation of the constrained mixture theory published pages: 1765-1777, ISSN: 1617-7959, DOI: 10.1007/s10237-017-0918-2 |
Biomechanics and Modeling in Mechanobiology 16/5 | 2020-03-23 |
| 2018 |
O. Trabelsi, M. Gutierrez, S. Farzaneh, A. Duprey, S. Avril A non-invasive methodology for ATAA rupture risk estimation published pages: 119-126, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2017.11.012 |
Journal of Biomechanics 66 | 2020-03-23 |
| 2018 |
Witold Krasny, Hélène Magoariec, Claire Morin, Stéphane Avril Kinematics of collagen fibers in carotid arteries under tension-inflation loading published pages: 718-726, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2017.08.014 |
Journal of the Mechanical Behavior of Biomedical Materials 77 | 2020-03-23 |
| 2017 |
Stéphane Avril Hyperelasticity of Soft Tissues and Related Inverse Problems published pages: 37-66, ISSN: , DOI: 10.1007/978-3-319-45071-1_2 |
2020-03-23 | |
| 2017 |
F. Condemi, S. Campisi, M. Viallon, T. Troalen, G. Xuexin, A. J. Barker, M. Markl, P. Croisille, O. Trabelsi, C. Cavinato, A. Duprey, S. Avril Fluid- and Biomechanical Analysis of Ascending Thoracic Aorta Aneurysm with Concomitant Aortic Insufficiency published pages: 2921-2932, ISSN: 0090-6964, DOI: 10.1007/s10439-017-1913-6 |
Annals of Biomedical Engineering 45/12 | 2020-03-23 |
| 2016 |
Matthew R. Bersi, Chiara Bellini, Paolo Di Achille, Jay D. Humphrey, Katia Genovese, Stéphane Avril Novel Methodology for Characterizing Regional Variations in the Material Properties of Murine Aortas published pages: 71005, ISSN: 0148-0731, DOI: 10.1115/1.4033674 |
Journal of Biomechanical Engineering 138/7 | 2020-03-23 |
| 2017 |
S. Jamaleddin Mousavi, Solmaz Farzaneh, Stéphane Avril Computational predictions of damage propagation preceding dissection of ascending thoracic aortic aneurysms published pages: e2944, ISSN: 2040-7939, DOI: 10.1002/cnm.2944 |
International Journal for Numerical Methods in Biomedical Engineering | 2020-03-23 |
| 2018 |
Francesca Condemi, Salvatore Campisi, Magalie Viallon, Pierre Croisille, Jean-François Fuzelier, Stéphane Avril Ascending thoracic aorta aneurysm repair induces positive hemodynamic outcomes in a patient with unchanged bicuspid aortic valve published pages: 145-148, ISSN: 0021-9290, DOI: 10.1016/j.jbiomech.2018.09.022 |
Journal of Biomechanics 81 | 2020-03-23 |
| 2018 |
VÃctor A. Acosta SantamarÃa, MarÃa Flechas GarcÃa, Jérôme Molimard, Stephane Avril Three-Dimensional Full-Field Strain Measurements across a Whole Porcine Aorta Subjected to Tensile Loading Using Optical Coherence Tomography–Digital Volume Correlation published pages: , ISSN: 2297-3079, DOI: 10.3389/fmech.2018.00003 |
Frontiers in Mechanical Engineering 4 | 2020-03-23 |
| 2018 |
V. A. Acosta SantamarÃa, G. Daniel, D. Perrin, J. N. Albertini, E. Rosset, S. Avril Model reduction methodology for computational simulations of endovascular repair published pages: 139-148, ISSN: 1025-5842, DOI: 10.1080/10255842.2018.1427740 |
Computer Methods in Biomechanics and Biomedical Engineering 21/2 | 2020-03-23 |
| 2019 |
Matthew R. Bersi, Chiara Bellini, Jay D. Humphrey, Stéphane Avril Local variations in material and structural properties characterize murine thoracic aortic aneurysm mechanics published pages: 203-218, ISSN: 1617-7959, DOI: 10.1007/s10237-018-1077-9 |
Biomechanics and Modeling in Mechanobiology 18/1 | 2020-03-23 |
| 2018 |
Nele Famaey, Julie Vastmans, Heleen Fehervary, Lauranne Maes, Emma Vanderveken, Filip Rega, S. Jamaleddin Mousavi, Stéphane Avril Numerical simulation of arterial remodeling in pulmonary autografts published pages: 2239-2257, ISSN: 0044-2267, DOI: 10.1002/zamm.201700351 |
ZAMM - Journal of Applied Mathematics and Mechanics / Zeitschrift für Angewandte Mathematik und Mechanik 98/12 | 2020-03-23 |
| 2018 |
Rossella Campobasso, Francesca Condemi, Magalie Viallon, Pierre Croisille, Salvatore Campisi, Stéphane Avril Evaluation of Peak Wall Stress in an Ascending Thoracic Aortic Aneurysm Using FSI Simulations: Effects of Aortic Stiffness and Peripheral Resistance published pages: 707-722, ISSN: 1869-408X, DOI: 10.1007/s13239-018-00385-z |
Cardiovascular Engineering and Technology 9/4 | 2020-03-23 |
| 2019 |
Solmaz Farzaneh, Olfa Trabelsi, Bertrand Chavent, Stéphane Avril Identifying Local Arterial Stiffness to Assess the Risk of Rupture of Ascending Thoracic Aortic Aneurysms published pages: , ISSN: 0090-6964, DOI: 10.1007/s10439-019-02204-5 |
Annals of Biomedical Engineering | 2020-03-23 |
| 2019 |
Solmaz Farzaneh, Olfa Trabelsi, Stéphane Avril Inverse identification of local stiffness across ascending thoracic aortic aneurysms published pages: 137-153, ISSN: 1617-7959, DOI: 10.1007/s10237-018-1073-0 |
Biomechanics and Modeling in Mechanobiology 18/1 | 2020-03-23 |
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