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BaCTher

Bacteria for Cancer Therapy

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BaCTher project word cloud

Explore the words cloud of the BaCTher project. It provides you a very rough idea of what is the project "BaCTher" about.

inhibiting    effect    agrave    superiore    compelling    relationship    vivo    bacteria    therapies    cancer    mechanism    model    nci    anticancer    bacther    host    attenuated    national    enterica    immune    back    outcome    therapeutic    znuabc    cells    post    hypothesis    spend    strategy    er    death    world    researcher    reprogramming    influence    cip    inflammation    immunobiology    organisation    re    microenvironment    expectancy    adenocarcinoma    transferred    models    24h    shift    balb    mice    skills    italy    antitumor    limitations    western    delta    proliferation    mammary    alternative    protumorigenic    di    md    preliminary    beneficiary    salmonella    tumor    center    sanit    iss    section    tme    stm    treatment    educating    overcome    intrinsic    life    improvement    scientific    usa    designed    istituto    exchange    serovar    immunity    penetrate    mutual    establishment    inducing    typhimurium    proliferate    observation    validate    reduce    division    countries    ccr    bethesda   

Project "BaCTher" data sheet

The following table provides information about the project.

Coordinator
ISTITUTO SUPERIORE DI SANITA 

Organization address
address: Viale Regina Elena 299
city: ROMA
postcode: 161
website: http://www.iss.it

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Italy [IT]
 Project website http://www.iss.it/spva/index.php
 Total cost 164˙203 €
 EC max contribution 164˙203 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-GF
 Starting year 2015
 Duration (year-month-day) from 2015-11-01   to  2017-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    ISTITUTO SUPERIORE DI SANITA IT (ROMA) coordinator 164˙203.00
2    United States Department of Health and Human Services US (Washington D.C.) partner 0.00

Map

 Project objective

Cancer is the second cause of death in the western world and it is expected to become the leading one in developing countries in the next future. The long-term outcome of BaCTher is the improvement of the cancer treatment that can overcome the intrinsic limitations of the current therapies through the development of a new promising therapeutic strategy. The specific hypothesis behind the proposed research is that an attenuated Salmonella enterica serovar Typhimurium (STMΔznuABC) is able to influence the tumor microenvironment (TME) reprogramming or re-educating the immune response, and inducing a shift from protumorigenic inflammation to anticancer immunity, which results in a tumor growth control. This hypothesis is based on the observation that: 1) there is compelling scientific evidence of the effect of bacteria, and in particular Salmonella, against cancer growth; 2) STMΔznuABC is able to reduce cancer growth and to increase the average life expectancy in a mammary adenocarcinoma Balb/c mice model; 3) STMΔznuABC is able to penetrate and proliferate into the tumor cells inhibiting the proliferation of tumor cells at 24h post-treatment. Three specific aims are designed to: 1) investigate the relationship between STMΔznuABC and TME; 2) characterize the mechanism of STMΔznuABC antitumor activity; 3) validate the results obtained in the preliminary studies using alternative in vivo models. The Experienced Researcher (ER), from the Istituto Superiore di Sanità (ISS), Italy, will spend one year at the Cancer Immunobiology Section of the Cancer and Inflammation Program (CIP), Center for Cancer Research (CCR), division of the National Cancer Institute (NCI), Bethesda, MD USA, for mutual exchange of skills and know-how that will be transferred back to the beneficiary organisation (ISS), contributing to the establishment of a wider long-term collaboration between the ER and host institutions.

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The information about "BACTHER" are provided by the European Opendata Portal: CORDIS opendata.

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