Explore the words cloud of the HspAdhesion project. It provides you a very rough idea of what is the project "HspAdhesion" about.
The following table provides information about the project.
Coordinator |
UNIVERSITAT LINZ
Organization address contact info |
Coordinator Country | Austria [AT] |
Project website | http://www.jku.at/biophysics/content/e54900/e275954 |
Total cost | 166˙156 € |
EC max contribution | 166˙156 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2014 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2015 |
Duration (year-month-day) | from 2015-05-01 to 2017-04-30 |
Take a look of project's partnership.
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1 | UNIVERSITAT LINZ | AT (LINZ) | coordinator | 166˙156.00 |
We propose an interdisciplinary project at the interface of biophysics, biochemistry, and medical research. Our objective is to investigate the specific role of cell membrane associated heat shock protein 70 (Hsp70) in the context of invasive cancer. In particular we address the question how cell membrane localization of Hsp70 affects differential adhesion of cancer cells and the formation of metastasis. In general, heat shock proteins (HSP) assist in folding of nascent proteins, prevent protein aggregation, and assist transport of proteins. Upon a variety of stresses HSP production is rapidly upregulated. Hsp70 is the major stress-inducible member of the HSP70 family. In normal cells it copes with harmful unfolded and denatured protein conferring protection to the cell. Tumor cells frequently present Hsp70 on their outer surface where it exhibits additional activities. For a number of different tumors a high level of membrane Hsp70 has been found to indicate drastically decreased survival chances in patients. Moreover it has been implicated in formation of metastasis where it might support spread and anchoring into distant tissues. These findings highlight the clinical significance of cell membrane associated Hsp70 and the need for a better understanding of its role in differential cell adhesion and progression of cancer. We will employ atomic force microscopy (AFM) in order to elucidate the function of membrane Hsp70 as a possible adhesion molecule or mediator of cellular adhesion. (1) Using single-cell force spectroscopy we will characterize and quantify adhesion forces of Hsp70 positive and negative cells to different substrates mimicking their interaction with extracellular matrix and host tissue. (2) With the help of a specialized AFM technique that enables topography imaging with a simultaneous recognition of specific surface molecules we will determine the localization and arrangement of Hsp70 molecules on the cell surface with nanometer resolution.
year | authors and title | journal | last update |
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2018 |
Constanze Lamprecht, Mathias Gehrmann, Josef Madl, Winfried Römer, Gabriele Multhoff, Andreas Ebner Molecular AFM imaging of Hsp70-1A association with dipalmitoyl phosphatidylserine reveals membrane blebbing in the presence of cholesterol published pages: , ISSN: 1355-8145, DOI: 10.1007/s12192-018-0879-0 |
Cell Stress and Chaperones | 2019-07-23 |
2017 |
Michael Leitner
Alexandra Poturnayova
Constanze Lamprecht
Sabine Weich
Maja SnejdarkovaIvana Karpisova
Tibor Hianik
Andreas Ebner Characterization of the specific interaction between the DNA aptamer sgc8c and protein tyrosine kinase-7 receptors at the surface of T-cells by biosensing AFM published pages: , ISSN: 1618-2642, DOI: 10.1007/s00216-017-0238-5 |
Analytical and Bioanalytical Chemistry | 2019-07-23 |
2017 |
Constanze Lamprecht, Jürgen Strasser, Lilia A. Chtcheglova, Melanie Köhler, Sandra Posch, Yoo Jin Oh, Rong Zhu, Andreas Ebner, Peter Hinterdorfer Biomedical Sensing with the Atomic Force Microscope published pages: 135-173, ISSN: , DOI: 10.1007/978-3-319-51433-8_4 |
Nanotribology and Nanomechanics | 2019-07-23 |
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The information about "HSPADHESION" are provided by the European Opendata Portal: CORDIS opendata.