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MULTICELL

Division of labour and the origin of multicellularity

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

MULTICELL project word cloud

Explore the words cloud of the MULTICELL project. It provides you a very rough idea of what is the project "MULTICELL" about.

cellular phenotype experimental inferred genotype phylogeny ago filament traits billion specialization mechanisms expression patterns linking interdisciplinary phylum drives organisms relates incompatible regimes differentiation genomes selective multicellularity biology contrasted wp1 transition laboratory model greatest labour first wp2 performing division later theory cells sequence cyanobacterial actually evolutionary consequence gene combining gain evolution populations single phylogenomics cyanobacteria multicellular view originates critical causes either genome physiologically happened artificial unicellular understanding predicts tested aggregates differentiated subjected underlying reconstruct events complexity

Project "MULTICELL" data sheet

The following table provides information about the project.

Coordinator	CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL Organization address address: OLSHAUSENSTRASSE 40 city: KIEL postcode: 24118 website: http://www.uni-kiel.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://www.mikrobio.uni-kiel.de/de/ag-dagan/mitarbeiterinnen/dr.-katrin-hammerschmidt
Total cost	171˙460 €
EC max contribution	171˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-RI
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2019-08-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL Organization address address: OLSHAUSENSTRASSE 40 city: KIEL postcode: 24118 website: http://www.uni-kiel.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KIEL)	coordinator	171˙460.00

Map

Project objective

Understanding the evolution of multicellularity and cellular differentiation/ complexity is one of the greatest challenges in biology. Of particular interest is to determine the evolutionary processes (selective causes) and mechanisms underlying the evolutionary transition from single cells to multicellular organisms.

This project will use cyanobacteria as a model system to determine whether cellular differentiation is a cause or consequence of multicellularity. A novel theory will be tested, which predicts that the division of labour/ differentiation among cells drives the transition to a multicellular state. This will be contrasted with the classical view, where cellular specialization originates only at a much later state during the transition. The proposed project will adopt an interdisciplinary approach by combining experimental evolution (WP1) with phylogenomics (WP2). More specifically, populations of unicellular cyanobacteria will be subjected to long-term experimental evolution under two different regimes that favour either the specialization of cells into performing different physiologically incompatible processes, or the formation of non-differentiated aggregates (WP1). By linking the phenotype to the underlying genotype and to gene expression patterns, the critical steps for the transition to multicellularity will be established at the genome level. This evolutionary sequence will be directly compared to the one inferred from the cyanobacterial phylogeny (WP2). Here, whole genomes will be used to reconstruct the gain and loss events for the main ‘multicellular traits’, such as filament formation and cellular differentiation.

The findings will not only provide insight into the key events during the transition to multicellularity but will also be the first study that directly relates a transition that was achieved under artificial conditions in the laboratory to one that actually happened more than 3 billion years ago in this phylum.

Publications

List of publications.
year	authors and title	journal	last update
2017	Robin Koch, Anne Kupczok, Karina Stucken, Judith Ilhan, Katrin Hammerschmidt, Tal Dagan Plasticity first: molecular signatures of a complex morphological trait in filamentous cyanobacteria published pages: , ISSN: 1471-2148, DOI: 10.1186/s12862-017-1053-5	BMC Evolutionary Biology 17/1	2020-02-06
2017	Oliver Otti, Peter Deines, Katrin Hammerschmidt, Klaus Reinhardt Regular Wounding in a Natural System: Bacteria Associated With Reproductive Organs of Bedbugs and Their Quorum Sensing Abilities published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2017.01855	Frontiers in Immunology 8	2020-02-06

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The information about "MULTICELL" are provided by the European Opendata Portal: CORDIS opendata.