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OsteoNano

Spatial nanoscale control of growth and adhesion factors to enhance the osteogenic differentiation of mesenchymal stem cells

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

OsteoNano project word cloud

Explore the words cloud of the OsteoNano project. It provides you a very rough idea of what is the project "OsteoNano" about.

sensitive recombinantly stiffness substrates glycosamminoglycans adhesives sites bmps human first orientation possibility density clinically heparan osteogenic alpha5beta1 induce presentation stem cellular osteonano prevents fractured bmp positively internalization sequences interaction cyclic hs biomimetic regarding guided manner beta3 rgd questions commitment alphav functionalized binding co activation hmscs surface fundamental adhesion advantages integrin respect combined rgds surfaces absence arrangement techniques versatility training sulphate bound bone gags resolution complexity morphogenetic molecules answer protein ectopic expressed mesenchymal linked breakthroughs differentiation healing cells spatial stepwise

Project "OsteoNano" data sheet

The following table provides information about the project.

Coordinator	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://www.lmgp.grenoble-inp.fr/annuaire-/elisa-migliorini--869551.kjsp
Total cost	159˙460 €
EC max contribution	159˙460 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2015
Duration (year-month-day)	from 2015-05-01 to 2017-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	coordinator	159˙460.00

Map

Project objective

In OsteoNano project the training-through-research is targeted at the developing of biomimetic surfaces to study and control the osteogenic differentiation of human Mesenchymal Stem Cells (hMSCs). Osteogenic differentiation of hMSCs can be guided by growth factors, such as bone morphogenetic protein 2 (BMP-2). Currently, recombinantly expressed BMP-2 is applied clinically to enhance the healing of fractured sites. However, the absence of a control over the growth factor surface density and adhesion of cells induce side effects such as ectopic bone formation. The first aim of this project is to present BMP-2 to hMSCs in a spatially controlled manner by applying surface sensitive and high-resolution techniques. The growth factors will be linked to the surface using glycosamminoglycans (GAGs) such as heparan sulphate (HS), and combined with adhesives molecules such as cyclic RGD sequences, which are known to increase the osteogenic effects of BMP-2 by activation of Integrin alphaV-beta3 and alpha5beta1. Our approach will be to design biomimetic surfaces with stepwise increasing complexity, by binding each component in a controlled manner, in terms of orientation, surface density and spatial arrangement. By using these functionalized substrates for hMSCs osteogenic differentiation we will answer several fundamental questions regarding the role of BMP-2 and its interaction with HS and RGD sequences on the osteogenic commitment of hMSCs. The biomimetic surfaces proposed here, present several fundamental studies, advantages and breakthroughs (i) reduced use of BMP-2 bound on the surface: indeed (i) the binding prevents the cellular internalization of the growth factors; (ii) possibility to enhance the osteogenic differentiation by surface co-presentation of BMPs or/and of RGDs; (iii) surface versatility with respect to stiffness which could positively impact osteogenic differentiation.

Publications

List of publications.
year	authors and title	journal	last update
2016	Elisa Migliorini, Anne Valat, Catherine Picart, Elisabetta Ada Cavalcanti-Adam Tuning cellular responses to BMP-2 with material surfaces published pages: 43-54, ISSN: 1359-6101, DOI: 10.1016/j.cytogfr.2015.11.008	Cytokine & Growth Factor Reviews 27	2019-07-24
2017	Elisa Migliorini, Patrick Horn, TamÃ¡s Haraszti, Seraphine V. Wegner, Christian Hiepen, Petra Knaus, Ralf P. Richter, Elisabetta Ada Cavalcanti-Adam Enhanced Biological Activity of BMP-2 Bound to Surface-Grafted Heparan Sulfate published pages: 1600041, ISSN: 2366-7478, DOI: 10.1002/adbi.201600041	Advanced Biosystems 27 March	2019-07-24

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The information about "OSTEONANO" are provided by the European Opendata Portal: CORDIS opendata.