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AGEISM

Lifelong health, markers of ageing and senescence in a long-lived mammal.

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

AGEISM project word cloud

Explore the words cloud of the AGEISM project. It provides you a very rough idea of what is the project "AGEISM" about.

indicators population records 240 lived q2 ageing ahead reduce given animals equally declines examine humans patterns endocrinological age q3 health telomere linking hormonal reproduction link bi decline q1 reproductive physiological mechanisms mammal disease dynamics critical molecular predicting first combine exact data history stress individual grasp predict lifelong variation exceptional decades exposure interact longevity life helps monthly evolutionary really markers q4 world elephants understand telomerase correlates demographic asian oxidative healthy n senescence rates

Project "AGEISM" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	http://elephant-project.science
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2014
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2017-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF SHEFFIELD THE UNIVERSITY OF SHEFFIELD Organization address address: FIRTH COURT WESTERN BANK city: SHEFFIELD postcode: S10 2TN website: www.shef.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (SHEFFIELD)	coordinator	183˙454.00

Map

Project objective

Given the ageing population in Europe, it is critical to understand the mechanisms involved in growing old. Our ability to reduce the impact of ageing in humans might be best studied in equally long-lived animals. Predicting future changes in longevity patterns might depend on our ability to develop indicators of how old we really are and how many healthy years we have ahead of us, and how those indicators depend on our health history across decades. My study will be the first linking lifelong disease history with physiological and molecular measures of ageing in a mammal as long-lived as humans. I will examine how different molecular ageing markers (telomere dynamics, oxidative stress and telomerase activity) interact with lifelong disease and reproductive history, and current endocrinological measures of stress and reproduction. This helps to better grasp both the mechanisms of ageing and their consequences on senescence rates, thus providing exceptional opportunities to identify the exact role of these markers in evolutionary processes and how they determine ageing rates and individual variation in senescence rates. It would also help us to establish which molecular markers best represent individual health history and to understand how health history can predict ageing rates. To do so, I will combine the world's most comprehensive demographic data on Asian elephants with bi-monthly health and disease records across life and with molecular ageing markers and hormonal correlates of stress and reproduction (N~240). I will determine: Q1.How does health decline with age? Q2.How does lifelong disease exposure and current health link with ageing markers? Q3.How does reproduction affect age-specific declines in health and current ageing markers? Q4.How does early stress affect age-specific declines in health and current ageing markers?

Publications

List of publications.
year	authors and title	journal	last update
2017	Sophie Reichert, Hannah Froy, Winnie Boner, Theresa M. Burg, Francis Daunt, Robert Gillespie, Kate Griffiths, Sue Lewis, Richard A. Phillips, Dan H. Nussey, Pat Monaghan Telomere length measurement by qPCR in birds is affected by storage method of blood samples published pages: 341-350, ISSN: 0029-8549, DOI: 10.1007/s00442-017-3887-3	Oecologia 184/2	2019-06-18
2017	Sophie Reichert, Antoine Stier Does oxidative stress shorten telomeres in vivo ? A review published pages: 20170463, ISSN: 1744-9561, DOI: 10.1098/rsbl.2017.0463	Biology Letters 13/12	2019-06-18

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The information about "AGEISM" are provided by the European Opendata Portal: CORDIS opendata.