BACTOSHAPE
Single cell biophysics of bacterial cell shape
Total Cost €
0EC-Contrib. €
0Partnership
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Project "BACTOSHAPE" data sheet
The following table provides information about the project.
| Coordinator |
INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT
Organization address contact info |
| Coordinator Country | France [FR] |
| Project website | https://www.micalis.fr/Poles-et-Equipes/Pole-Biosys/ProCeD-Carballido-Lopez/Anciens-membres/Benoit-TESSON |
| Total cost | 185˙076 € |
| EC max contribution | 185˙076 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2014 |
| Funding Scheme | MSCA-IF-EF-RI |
| Starting year | 2015 |
| Duration (year-month-day) | from 2015-04-01 to 2017-03-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | INSTITUT NATIONAL DE RECHERCHE POUR L'AGRICULTURE, L'ALIMENTATION ET L'ENVIRONNEMENT | FR (PARIS CEDEX 07) | coordinator | 185˙076.00 |
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Project objective
In bacteria, the rigid external cell wall (CW) and the intracellular actin-like (MreB) cytoskeleton are major determinants of cell shape. Synthesis and chemical composition of the CW, a three dimensional polymer network that is one of the most prominent targets for antibiotics, are well understood. However, despite decades of study, little is known about the complex CW ultrastructure and the molecular mechanisms that control cell shape in time and space. MreB homologues assemble into dynamic membrane-associated structures thought to control shape by serving as organizers for the movement and assembly of macromolecular machineries responsible for CW biogenesis. However, the mechanistic details used by the MreB cytoskeleton to fulfill this role remain to be elucidated. We will combine powerful genetic tools available in the model Gram-positive bacterium Bacillus subtilis with modern high-resolution fluorescence microscopy techniques and atomic force microscopy (AFM) to study the role of the MreB cytoskeleton and CW synthesis proteins in cell shape determination and maintenance. Additionally, the role of mechanical forces in the control of CW organization will be evaluated.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Alex Dajkovic, Benoit Tesson, Smita Chauhan, Pascal Courtin, Ruth Keary, Pierre Flores, Christian Marlière, Sérgio R. Filipe, Marie-Pierre Chapot-Chartier, Rut Carballido-Lopez Hydrolysis of peptidoglycan is modulated by amidation of meso -diaminopimelic acid and Mg 2+ in B acillus subtilis published pages: 972-988, ISSN: 0950-382X, DOI: 10.1111/mmi.13673 |
Molecular Microbiology 104/6 | 2019-06-18 |
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