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iBack SIGNED

Individualized treatment planning in chronic back pain patients by advanced imaging and multi-parametric biomechanical models

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

iBack project word cloud

Explore the words cloud of the iBack project. It provides you a very rough idea of what is the project "iBack" about.

scaling individualize routine surgeon back strategies perform compute interactions decision indices criteria balance treat additionally model strength chronic burden 85 impacts experiencing surgery 92 iback worldwide predict conservative source surgical biomechanical disability primarily bone elderly mineral body lt mg sagittal resonance image clinical post treatment pathophysiologic patients ct pain statistical loosening restore simulation finite screw density therapy tomography understand personalized tools radiographs mbs vivo computed combining reveal attributed prolonged underlying individual prediction outcome individualized cell subjective spine mri models magnetic gt probability osteoporosis planning instability scenario complicates imaging influences ccm occurs fracture

Project "iBack" data sheet

The following table provides information about the project.

Coordinator	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 website: http://www.med.tu.muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://deep-spine.de
Total cost	1˙493˙492 €
EC max contribution	1˙493˙492 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-06-01 to 2020-11-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN KLINIKUM RECHTS DER ISAR DER TECHNISCHEN UNIVERSITAT MUNCHEN Organization address address: ISMANINGER STRASSE 22 city: MUENCHEN postcode: 81675 website: http://www.med.tu.muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	coordinator	1˙229˙616.00
2	TECHNISCHE UNIVERSITAET MUENCHEN TECHNISCHE UNIVERSITAET MUENCHEN Organization address address: Arcisstrasse 21 city: MUENCHEN postcode: 80333 website: www.tu-muenchen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	263˙876.00

Map

Project objective

Chronic back pain is a major burden and source of disability worldwide. It is primarily attributed to biomechanical factors. In elderly patients, osteoporosis complicates the biomechanical scenario. Surgery is often required to treat instability-related pain and to restore the balance of the spine. However, when and how to perform surgery remains a highly subjective decision based on the surgeon’s experience, with 2/3 of patients experiencing prolonged pain. We recently established objective, image-based criteria for surgery outcome prediction. As an example, we were able to develop tools for routine density and fracture assessment and demonstrate that screw loosening occurs in >85% of patients with bone mineral density <92 mg/ccm. This directly influences the surgical approach in all spine surgery patients at our institution. Additionally, we improved the prediction of bone strength by advanced image post processing such as scaling indices, finite element and finite cell models. The high-level objective of iBack is to individualize therapy planning in back pain patients. We will improve in-vivo imaging and image analysis to compute individualized biomechanical models that reveal the underlying pathophysiologic process and allow personalized treatment planning and outcome prediction after spine surgery or conservative treatment. The main objectives of iBack are: (1) improving computed tomography (CT) and magnetic resonance imaging (MRI) of the spine; (2) combining sagittal balance radiographs, CT and MRI of the spine in one biomechanical multi-body simulation (MBS); (3) creating a statistical model that includes both clinical and biomechanical information to reveal interactions between the two and to predict individual treatment success probability. The results of iBack will help to better understand instability-related pain and develop personalized surgical strategies which will have major impacts on patients.

Publications

List of publications.
year	authors and title	journal	last update
2019	Michael Dieckmeyer, Stefan Ruschke, Alexander Rohrmeier, Jan SyvÃ¤ri, Ingo Einspieler, Vanadin Seifert-Klauss, Monika Schmidmayr, Stephan Metz, Jan S. Kirschke, Ernst J. Rummeny, Claus Zimmer, Dimitrios C. Karampinos, Thomas Baum Vertebral bone marrow fat fraction changes in postmenopausal women with breast cancer receiving combined aromatase inhibitor and bisphosphonate therapy published pages: , ISSN: 1471-2474, DOI: 10.1186/s12891-019-2916-2	BMC Musculoskeletal Disorders 20/1	2020-01-30
2019	Ferdinand Roski, Johannes Hammel, Kai Mei, Thomas Baum, Jan S. Kirschke, Alexis Laugerette, Felix K. Kopp, Jannis Bodden, Daniela Pfeiffer, Franz Pfeiffer, Ernst J. Rummeny, Peter B. NoÃ«l, Alexandra S. Gersing, Benedikt J. Schwaiger Bone mineral density measurements derived from dual-layer spectral CT enable opportunistic screening for osteoporosis published pages: 6355-6363, ISSN: 0938-7994, DOI: 10.1007/s00330-019-06263-z	European Radiology 29/11	2020-01-30
2019	Stephanie Inhuber, Nico Sollmann, Sarah Schlaeger, Michael Dieckmeyer, Egon Burian, Caroline Kohlmeyer, Dimitrios C. Karampinos, Jan S. Kirschke, Thomas Baum, Florian Kreuzpointner, Ansgar Schwirtz Associations of thigh muscle fat infiltration with isometric strength measurements based on chemical shift encoding-based water-fat magnetic resonance imaging published pages: , ISSN: 2509-9280, DOI: 10.1186/s41747-019-0123-4	European Radiology Experimental 3/1	2020-01-30
2019	Sarah Schlaeger, Dominik Weidlich, Elisabeth Klupp, Federica Montagnese, Marcus Deschauer, Benedikt Schoser, Sarah Bublitz, Stefan Ruschke, Claus Zimmer, Ernst J. Rummeny, Jan S. Kirschke, Dimitrios C. Karampinos Water T 2 Mapping in Fatty Infiltrated Thigh Muscles of Patients With Neuromuscular Diseases Using a T 2 â€Prepared 3D Turbo Spin Echo With SPAIR published pages: , ISSN: 1053-1807, DOI: 10.1002/jmri.27032	Journal of Magnetic Resonance Imaging	2020-01-30
2017	Lam Nguyen, Stein Stoter, Thomas Baum, Jan Kirschke, Martin Ruess, Zohar Yosibash, Dominik Schillinger Phase-field boundary conditions for the voxel finite cell method: Surface-free stress analysis of CT-based bone structures published pages: e2880, ISSN: 2040-7939, DOI: 10.1002/cnm.2880	International Journal for Numerical Methods in Biomedical Engineering 33/12	2019-12-02
2018	Barbara Cervantes, Anh T. Van, Dominik Weidlich, Hendrick Kooijman, Andreas Hock, Ernst J. Rummeny, Alexandra Gersing, Jan S. Kirschke, Dimitrios C. Karampinos Isotropic resolution diffusion tensor imaging of lumbosacral and sciatic nerves using a phase-corrected diffusion-prepared 3D turbo spin echo published pages: 609-618, ISSN: 0740-3194, DOI: 10.1002/mrm.27072	Magnetic Resonance in Medicine 80/2	2019-12-02
2019	J.N. Jomo, F. de Prenter, M. Elhaddad, D. D\'Angella, C.V. Verhoosel, S. Kollmannsberger, J.S. Kirschke, V. NÃ¼bel, E.H. van Brummelen, E. Rank Robust and parallel scalable iterative solutions for large-scale finite cell analyses published pages: 14-30, ISSN: 0168-874X, DOI: 10.1016/j.finel.2019.01.009	Finite Elements in Analysis and Design 163	2019-12-02
2017	Kai Mei, Benedikt J. Schwaiger, Felix K. Kopp, Sebastian Ehn, Alexandra S. Gersing, Jan S. Kirschke, Daniela Muenzel, Alexander A. Fingerle, Ernst J. Rummeny, Franz Pfeiffer, Thomas Baum, Peter B. NoÃ«l Bone mineral density measurements in vertebral specimens and phantoms using dual-layer spectral computed tomography published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-17855-4	Scientific Reports 7/1	2019-12-02
2016	Felix K. Kopp, Konstantin Holzapfel, Thomas Baum, Radin A. Nasirudin, Kai Mei, Eduardo G. Garcia, Rainer Burgkart, Ernst J. Rummeny, Jan S. Kirschke, Peter B. NoÃ«l Effect of Low-Dose MDCT and Iterative Reconstruction on Trabecular Bone Microstructure Assessment published pages: e0159903, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0159903	PLOS ONE 11/7	2019-12-02
2016	D. Anitha, Karupppasamy Subburaj, Kai Mei, Felix K. Kopp, Peter Foehr, Peter B. Noel, Jan S. Kirschke, Thomas Baum Effects of dose reduction on bone strength prediction using finite element analysis published pages: 38441, ISSN: 2045-2322, DOI: 10.1038/srep38441	Scientific Reports 6	2019-12-02
2018	Mohamed Elhaddad, Nils Zander, Tino Bog, LÃ¡szlÃ³ Kudela, Stefan Kollmannsberger, Jan S. Kirschke, Thomas Baum, Martin Ruess, Ernst Rank Multi-level h p -finite cell method for embedded interface problems with application in biomechanics published pages: , ISSN: 2040-7939, DOI: 10.1002/cnm.2951	International Journal for Numerical Methods in Biomedical Engineering	2019-12-02
2016	Thomas Baum, Christian Cordes, Michael Dieckmeyer, Stefan Ruschke, Daniela Franz, Hans Hauner, Jan S. Kirschke, Dimitrios C. Karampinos MR-based assessment of body fat distribution and characteristics published pages: 1512-1518, ISSN: 0720-048X, DOI: 10.1016/j.ejrad.2016.02.013	European Journal of Radiology 85/8	2019-12-02
2018	Thomas Baum, Alexander Rohrmeier, Jan SyvÃ¤ri, Maximilian N. Diefenbach, Daniela Franz, Michael Dieckmeyer, Andreas Scharr, Hans Hauner, Stefan Ruschke, Jan S. Kirschke, Dimitrios C. Karampinos Anatomical Variation of Age-Related Changes in Vertebral Bone Marrow Composition Using Chemical Shift Encoding-Based Waterâ€“Fat Magnetic Resonance Imaging published pages: , ISSN: 1664-2392, DOI: 10.3389/fendo.2018.00141	Frontiers in Endocrinology 9	2019-12-02
2017	Thomas Baum; Christian Holwein; Christoph Schaeffeler; Klaus Woertler; Imhoff, Andreas B; Kirschke, Jan S.; Ernst J Rummeny; Jungmann, Pia M.; Sepp Braun Diagnostic Value of CT Arthrography for Evaluation of Osteochondral Lesions at the Ankle published pages: , ISSN: 2314-6141, DOI: 10.1155/2016/3594253	BioMed Research International, Vol 2016 (2016) 1	2019-12-02
2017	Elisabeth Klupp, Dominik Weidlich, Sarah Schlaeger, Thomas Baum, Barbara Cervantes, Marcus Deschauer, Hendrik Kooijman, Ernst J. Rummeny, Claus Zimmer, Jan S. Kirschke, Dimitrios C. Karampinos B1-insensitive T2 mapping of healthy thigh muscles using a T2-prepared 3D TSE sequence published pages: e0171337, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0171337	PLOS ONE 12/2	2019-12-02
2016	Thomas Baum, Stephanie Inhuber, Michael Dieckmeyer, Christian Cordes, Stefan Ruschke, Elisabeth Klupp, Pia M. Jungmann, Rosanna Farlock, Holger Eggers, Hendrik Kooijman, Ernst J. Rummeny, Ansgar Schwirtz, Jan S. Kirschke, Dimitrios C. Karampinos Association of Quadriceps Muscle Fat With Isometric Strength Measurements in Healthy Males Using Chemical Shift Encoding-Based Water-Fat Magnetic Resonance Imaging published pages: 447-451, ISSN: 0363-8715, DOI: 10.1097/RCT.0000000000000374	Journal of Computer Assisted Tomography 40/3	2019-12-02
2016	Johannes Kaesmacher, Hans Liebl, Thomas Baum, Jan Stefan Kirschke Bone Mineral Density Estimations From Routine Multidetector Computed Tomography published pages: 1, ISSN: 0363-8715, DOI: 10.1097/RCT.0000000000000518	Journal of Computer Assisted Tomography	2019-12-02
2017	Kai Mei, Felix K. Kopp, Rolf Bippus, Thomas KÃ¶hler, Benedikt J. Schwaiger, Alexandra S. Gersing, Andreas Fehringer, Andreas Sauter, Daniela MÃ¼nzel, Franz Pfeiffer, Ernst J. Rummeny, Jan S. Kirschke, Peter B. NoÃ«l, Thomas Baum Is multidetector CT-based bone mineral density and quantitative bone microstructure assessment at the spine still feasible using ultra-low tube current and sparse sampling? published pages: 5261-5271, ISSN: 0938-7994, DOI: 10.1007/s00330-017-4904-y	European Radiology 27/12	2019-12-02

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