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sRNA-EMB SIGNED

Small RNA regulation of the body plan and epigenome in Arabidopsis embryos

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

sRNA-EMB project word cloud

Explore the words cloud of the sRNA-EMB project. It provides you a very rough idea of what is the project "sRNA-EMB" about.

diverse fundamental differentiation patterns quantify types rnas plants embryo basic arabidopsis division epigenome animals regarding functions genome sequencing utilize fluorescent regulate arranged epigenomic morphologically genetic technologies expression differentiate embryonic fusion embryos coding roles mixture profiles ideal influence regulatory structures nascent invariant gene generate positions genomic cellular lastly embryogenesis little individual plan establishing cell mirna proper undergo modified protein plant body regulation thaliana designed events repressive correct interactions abundance small generation reprogramming mirnas rna

Project "sRNA-EMB" data sheet

The following table provides information about the project.

Coordinator	GREGOR MENDEL INSTITUT FUR MOLEKULARE PFLANZENBIOLOGIE GMBH Organization address address: DR BOHR GASSE 3 city: WIEN postcode: 1030 website: www.gmi.oeaw.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Austria [AT]
Project website	https://www.gmi.oeaw.ac.at/research-groups/michael-nodine/
Total cost	1˙499˙988 €
EC max contribution	1˙499˙988 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-07-01 to 2020-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	GREGOR MENDEL INSTITUT FUR MOLEKULARE PFLANZENBIOLOGIE GMBH GREGOR MENDEL INSTITUT FUR MOLEKULARE PFLANZENBIOLOGIE GMBH Organization address address: DR BOHR GASSE 3 city: WIEN postcode: 1030 website: www.gmi.oeaw.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	coordinator	1˙499˙988.00

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Project objective

Small RNAs are short non-coding RNAs that regulate gene expression in plants and animals. Although small RNAs are essential for proper differentiation and epigenome regulation, little is known regarding their embryonic functions, especially in plants. Arabidopsis thaliana is a leading system to study the regulatory roles of small RNAs because of the abundance of genetic, genomic and epigenomic resources. Moreover, Arabidopsis embryos undergo invariant division patterns and rapidly differentiate to generate the most basic plant cell-types arranged in correct positions. Early Arabidopsis embryos are therefore morphologically simple structures composed of diverse cell types making them ideal for determining the influence of small RNAs on fundamental cellular differentiation and reprogramming events. The objectives of the proposed research are designed to assess the regulatory roles of small RNAs in establishing both the basic body plan and epigenome in plant embryos. We will utilize modified next-generation sequencing technologies to identify small RNAs present in developing embryos. Because we will generate these RNA profiles from a mixture of cell-types, we will also use a fluorescent protein-based approach to quantify specific miRNA repressive activities in individual cell-types. To determine the functions of individual miRNA/target interactions during embryogenesis, we will identify miRNAs required for embryo development and use genome-wide approaches to study specific miRNA/target interactions in greater detail. Lastly, we will use a fusion of genetic and genomic methods to determine how small RNAs influence the nascent epigenome during early embryogenesis.

Publications

List of publications.
year	authors and title	journal	last update
2018	Michael A. Schon, Max J. Kellner, Alexandra Plotnikova, Falko Hofmann, Michael D. Nodine NanoPARE: parallel analysis of RNA 5â€² ends from low-input RNA published pages: 1931-1942, ISSN: 1088-9051, DOI: 10.1101/gr.239202.118	Genome Research 28/12	2020-03-20
2019	Falko Hofmann, Michael A. Schon, Michael D. Nodine The embryonic transcriptome of Arabidopsis thaliana published pages: 77-91, ISSN: 2194-7953, DOI: 10.1007/s00497-018-00357-2	Plant Reproduction 32/1	2020-03-20
2019	Alexandra Plotnikova, Max J. Kellner, Michael A. Schon, Magdalena Mosiolek, Michael D. Nodine MicroRNA Dynamics and Functions During Arabidopsis Embryogenesis published pages: 2929-2946, ISSN: 1040-4651, DOI: 10.1105/tpc.19.00395	The Plant Cell 31/12	2020-03-20
2017	Stefan Lutzmayer, Balaji Enugutti, Michael D. Nodine Novel small RNA spike-in oligonucleotides enable absolute normalization of small RNA-Seq data published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-017-06174-3	Scientific Reports 7/1	2020-03-20
2017	Michael A. Schon, Michael D. Nodine Widespread Contamination of Arabidopsis Embryo and Endosperm Transcriptome Data Sets published pages: 608-617, ISSN: 1040-4651, DOI: 10.1105/tpc.16.00845	The Plant Cell 29/4	2020-03-20

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