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BARREL

Barrel Assemblies of Membrane Active Artificial Foldamers

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 BARREL project word cloud

Explore the words cloud of the BARREL project. It provides you a very rough idea of what is the project "BARREL" about.

coupled    expertise    ideal    ray    toxicity    govern    lipophilic    bilayer    excellent    dormant    oligomer    lipid    natural    experimental    internal    gain    mechanism    enzyme    scaffold    function    polarized    lab    scattering    membranes    assemble    hope    solution    cells    antibiotics    theoretical    assemblies    waxs    constructs    foldamer    position    slow    hindering    techniques    positive    strategies    diversity    tools    equipped    additional    potentially    persistent    chances    barrel    protect    toxic    content    exploited    bota    model    sheet    membrane    relationships    environment    showing    oligomers    rational    saxs    qm    designed    hydrophilic    foldamers    professionally    antibiotic    md    peptide    molecular    development    structural    antimicrobial    interactions    fundamentals    optimal    light    host    structure    computationally    prof    characterisation    parts    spectroscopy    tenured    peptides    structures    outreach    bacteria    compounds    scaffolds    resistance    attila   

Project "BARREL" data sheet

The following table provides information about the project.

Coordinator
TERMESZETTUDOMANYI KUTATOKOZPONT 

Organization address
address: MAGYAR TUDOSOK KORUTJA 2
city: BUDAPEST
postcode: 1117
website: www.ttk.mta.hu

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Hungary [HU]
 Project website http://palyazat.ttk.mta.hu/ttk/
 Total cost 146˙239 €
 EC max contribution 146˙239 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2014
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2015
 Duration (year-month-day) from 2015-08-01   to  2017-07-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    TERMESZETTUDOMANYI KUTATOKOZPONT HU (BUDAPEST) coordinator 146˙239.00

Map

 Project objective

Development of resistance by bacteria to antibiotics makes design of novel antimicrobial compounds increasingly important. As persistent cells often become slow-growing or dormant, strategies targeting their membrane are becoming more relevant. For several natural antimicrobial peptides function can be coupled to scaffolds with high sheet content. Toxic oligomers may assemble into hydrophilic or lipophilic sheet rich barrel constructs. However, this mechanism is not understood, greatly hindering rational development of similar compounds. My main research goal is to reach insight into the structure-function relationships of the barrel molecular scaffold and to gain understanding of how its ability to protect internal parts from the environment may contribute to toxicity. To approach this problem, I aim to design and study foldamer oligomer assemblies. I hope to define the fundamentals of how peptide - lipid bilayer interactions govern formation of potentially toxic oligomers at a molecular level. This may be exploited for developing new antimicrobial compounds. Foldamers are highly similar to natural peptides in terms of structural diversity, thus they are ideal model systems, in several cases showing antibiotic activity and enzyme resistance. The computationally designed, structures will be studied with experimental methods in model membranes. I have experience with theoretical (QM&MD) and experimental tools (polarized light spectroscopy). However, characterisation of solution phase membrane systems requires use of additional techniques and I aim to learn more into X-ray scattering methods (SAXS,WAXS). In the lab of Prof. Attila Bota, I will have optimal conditions to gain expertise with these. The Host Institute will also provide a professionally organized and equipped environment, where I would have excellent chances to be offered a tenured position. I expect that the results and the planned outreach activities will have a positive impact on EU research.

 Publications

year authors and title journal last update
List of publications.
2016 Johan R. Johansson, Tamás Beke-Somfai, Anna Said Stålsmeden, and Nina Kann
Ruthenium-Catalyzed Azide Alkyne Cycloaddition Reaction: Scope, Mechanism, and Applications
published pages: , ISSN: 0009-2665, DOI:
Chemical Reviews 2019-07-24
2017 Ferenc Zsila, Szilvia Bősze, Kata Horváti, Imola Cs. Szigyártó and Tamás Beke-Somfaia
Drug and dye binding induced folding of the intrinsically disordered antimicrobial peptide CM15
published pages: , ISSN: 2046-2069, DOI:
RSC Advances 2019-07-24

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