#	Pagina
attuale pagina	/open-h2020/projects/198159/index.html

Opendata, web and dolomites

MetAGEn SIGNED

Metabolic and Genetic Regulation of Ageing

Total Cost €

EC-Contrib. €

Partnership

Views

Outcomes and
results

MetAGEn project word cloud

Explore the words cloud of the MetAGEn project. It provides you a very rough idea of what is the project "MetAGEn" about.

unknown protein aggregation implicated truly preliminary underpinnings mouse ageing reduce slow sequencing cultured regulators caenorhabditis neurodegeneration molecular cells mutagenesis activate perform insufficiently hexosamine found ways humans modulators proteolytic screens counter diseases seeking generation mammals age explore species manner interdisciplinary conservation endogenous time mechanism mutations biology mechanisms mammalian physiological unbiased activation longevity link data extends despite reveal almost uncover screen molecules decline metabolic quality causes lifespan paired modulation cellular direct model interrogate innovative understand genetic first capacity elegans progressive homeostasis metabolites genome suggesting

Project "MetAGEn" data sheet

The following table provides information about the project.

Coordinator	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	http://denzellab.com/lab-life2/
Total cost	1˙500˙000 €
EC max contribution	1˙500˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2014-STG
Funding Scheme	ERC-STG
Starting year	2015
Duration (year-month-day)	from 2015-08-01 to 2020-07-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV Organization address address: HOFGARTENSTRASSE 8 city: MUENCHEN postcode: 80539 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	coordinator	1˙500˙000.00

Map

Project objective

Ageing is a complex physiological process that affects almost all species, including humans. Despite its importance for all of us, the biology of ageing is insufficiently understood. To uncover the molecular underpinnings of ageing, I propose an interdisciplinary research program that will identify and investigate metabolic and genetic regulators of ageing. Progressive loss of cellular homeostasis causes ageing and an age-associated decline in protein quality control has been implicated in numerous diseases, including neurodegeneration. Seeking for ways to improve protein quality, I have identified a novel longevity pathway in Caenorhabditis elegans. In a forward genetic screen, I found a link between metabolites in the hexosamine pathway and cellular protein quality control. Hexosamine pathway activation extends C. elegans lifespan, suggesting modulation of ageing by endogenous molecules. In a first step, I will explore the mechanism by which hexosamine metabolites improve protein quality control in mammals, using cultured mammalian cells and a mouse model for neurodegeneration. Preliminary data show that hexosamine pathway metabolites enhance proteolytic capacity in cells and reduce protein aggregation, suggesting conservation. Second, I will investigate molecular mechanisms that activate the hexosamine pathway to promote protein homeostasis and counter ageing. Third, I will perform a direct forward genetic screen for modulators of ageing in C. elegans. For the first time, mutagenesis and next generation sequencing can be paired in forward genetic screens to interrogate the whole genome for lifespan-extending mutations in a truly unbiased manner. This innovative approach has the potential to reveal novel modulators of the ageing process. Taken together, this work aims to understand molecular mechanisms that maintain cellular homeostasis to slow the ageing process, and to develop a new technology to identify yet unknown genetic modulators of ageing.

Publications

List of publications.
year	authors and title	journal	last update
2018	Moritz Horn, Virginia Kroef, Kira Allmeroth, Nicole Schuller, Stephan Miethe, Martin Peifer, Josef M. Penninger, Ulrich Elling, Martin S. Denzel Unbiased compound-protein interface mapping and prediction of chemoresistance loci through forward genetics in haploid stem cells published pages: , ISSN: 1949-2553, DOI: 10.18632/oncotarget.24305	Oncotarget 9/11	2019-05-29

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "METAGEN" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "METAGEN" are provided by the European Opendata Portal: CORDIS opendata.