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SyMBioSys project deliverables

The page lists 23 deliverables related to the research project "SyMBioSys".

 List of Deliverables

SyMBioSys: list of downloadable deliverables.
title and desprition type last update

Methodology for reverse engineering: model selection and parameter identification

A systematic methodology will be investigated for reverse engineering: model selection and parameter identification using systematic model-based techniques. Validation studies

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Public dissemination of project results

In order to ensure that the project results are efficiently disseminated to scientific and industrial communities, the partners will implement specific measures. A dedicated work package has been defined to ensure the implementation of these measures as well as effective knowledge transfer among the partners. The partners will disseminate information about the goals of the project, ongoing activities, progress, results and the potential benefits and opportunities for Academia and the private sector.
As first measure, the partners will use their own academic and industrial networks for dissemination. In addition, it is expected that at least 30 scientific papers (at least two per ESR), will be published in peer-reviewed journals. For each of the ESRs, one of the required publications will be submitted to a journal familiar to the biological systems engineering community (e.g. Biotechnology and Bioengineering, IEEE Transactions on Biomedical Engineering, Computers and Chemical Engineering, PLOS Computational Biology) and one publication will be submitted to a journal transcending the community (for more mathematical projects, relevant publications include: Journal of Global Optimization, INFORMS Journal of Computing, Optimization Methods and Software; for more biological projects, relevant publications include Proceedings of the National Academy of Sciences; Leukemia). Further dissemination activities will include:
- Reporting software to facilitate exchange of data between the partners (Emdesk);
- Presentations at scientific conferences;
- Press-releases for the local and international media;
- Organization of workshops with the participation of renowned scientists and external industrial leaders.
The project partners will communicate and disseminate the results to several target sectors: scientific community (researchers and students), relevant industrial sectors, general public, potential investors/stakeholders. To ensure the access to the project results, all scientific publications will be made under the open-access concept – i.e. free of charge online access for the user. Both open access publishing and self-archiving options will be considered (also called ‚gold‛ or ‚green‛ open access model, respectively).

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Kinetic model describing E.coli central metabolism

A new kinet model describing E.coli central metabolism. The model will account for the underlying complexities and constraints

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Transferable skills courses

Scientific publishing and dissemination.: Writing with a clear and direct style and plan, research, organize and compose a literature review; Practice skills on both sides of the camera and microphone, as well as gaining experience of effective scientific writing under real time pressure; Research Ethics, and Bioethics which will cover topics such as “The fabrication/falsification of Data”, “Professional and Personal Integrity”, “Plagiarism and Collusion”, and “Medical Research”; The relationship between communication, science and policymaking in both the developed and developing world.

Entrepreneurship and IP management: Development of entrepreneurship skills including: idea generation; learning how to get investors excited; understanding marketing, design, and legal matters; Understanding of the technology behind the product. The students will have the opportunity to understand development processes and acquire project management skills. The students will also end up with an overview of White and Red Biotech market; Protection of intellectual property including: obtaining patents; licensing technology to established companies; copyrighting software; initiating start-ups

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Other 2020-03-20

Final report

The final report will be prepared and submitted according the contractual requirements and reporting rules.

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Multi-scale models to capture heterogeneity in biological systems

New multi-scale population balance models to capture heterogeneity in biological systems

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Conference organization

Organization of an open conference on “Systematic Models for Biological Systems Engineering”

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Other 2020-03-20

Science-based courses

Selected Science-based courses include network-wide workshops and seminars to be attended by all recruited research. These includ: (i) Introduction to biological systems and bioprocesses model definition (ii) Fundamental Experimental Techniques for Biological Systems (iii) Kinetic model building in biological systems engineering (iv)Optimality principles in biological systems (v) Model-based metabolic engineering (vi) Informatics for Biological Systems

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Other 2020-03-20

Methodology to identify both structure and parameters of large signalling models

A systematic methodology will be investigated to to identify both structure and parameters of large signalling models. Validation studies will be also performed.

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Methodology for global dynamic optimization of cellular processes

A new methodology for global dynamic optimization of cellular processes will be investigated. The methodology will be validated in several problems in collaboration with the partners..

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Methodology to model jointly signaling, regulatory and metabolic networks

Kinetic modeling of metabolic behavior including transcriptional regulation. The proposed modelling framework will integrate signal transduction, regulation and metabolism into dynamic mathematical models

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Doctoral degrees

Doctoral degrees will be awarded to ESRs after succesfull completion of their Doctoral work.

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Other 2020-03-20

\"Optimal operation profile capturing heterogeneity of \"\"high-fidelity\"\" bioprocess\"

\"To derive an optimal operation profile capturing heterogeneity of \"\"high-fidelity\"\" bioprocess models. A salient feature of the proposed approach is to develop model and techniques which are computationally tractable\"

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Mathematical model-based strategy for the detection of drug targets

A novel mathematical model-based strategy will be investigated for the detection of drug targets

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Mathematical model to describe regulation of metabolism by dynamic cell

New mathematical model to describe regulation of metabolism by dynamic cell signalling.

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

SyMBioSys Website

A SyMBioSys website will be set-up and maintained as an effective mean of communication between the participants and also for training and dissemination purposes.

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Other 2020-03-20

SyMBioSys vacancies published

Vacancies will be published simultaneously through various media: European and world-wide read journals (e.g. Nature Jobs, jobs.ac.uk) for academic-related job adverts, the EU portal for jobs advert, the Commission’s own pages for the Marie Skłodowska-Curie Actions, SyMBioSys project website, beneficiaries’ graduate recruiting procedures, and informal approaches to colleagues both in academia and industry. The aim is to have a shortlist of candidates, with CVs and references available before the contracts are signed to ensure that prompt interviews would take place and researchers could be recruited on time.

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Other 2020-03-20

Researchers declaration of conformity

Researchers declaration of conformity will be submitted on-line to the portal

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Methodology for a more systematic model building, and subsequent model

A systematic methodology will be investigated for a more systematic model building, and subsequent model reduction for control and optimization purposes. Novel model-reduction techniques will be investigated and their accuracy will be assessed in example problems.

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Integrated experimental-modeling platform to tailor treatments in a patient-specific

An Integrated experimental-modeling platform will be developed to tailor treatments in a patient-specific and leukemia-specific chemotherapy schedule

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Model-based dynamic optimization methods to explain (a posteriori use) or predict

Optimal control formulations will be developed (using a mixed-integer dynamic optimization framework) to explain (a posteriori use) or predict (a priori use) the operating principles in metabolic and signaling pathways

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Kinetic model of human metabolism derived

To derive a new model of human metabolism. The model will account for uncertainty and incorporate stoichiometric, thermodynamic and physiological constraints

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20

Development of an in silico leukemia model

A novel in silico leukemia model will be developed and solved using efficient computational; techniques.

Programme: H2020-EU.1.3.1. - Topic(s): MSCA-ITN-2015-ETN

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Documents, reports 2020-03-20