Explore the words cloud of the MicMactin project. It provides you a very rough idea of what is the project "MicMactin" about.
The following table provides information about the project.
Coordinator |
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Organization address contact info |
Coordinator Country | France [FR] |
Total cost | 1˙491˙868 € |
EC max contribution | 1˙491˙868 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-STG |
Funding Scheme | ERC-STG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-06-01 to 2021-05-31 |
Take a look of project's partnership.
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1 | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS | FR (PARIS) | coordinator | 1˙491˙868.00 |
'Biological motion and forces originate from mechanically active proteins operating at the nanometer scale. These individual active elements interact through the surrounding cellular medium, collectively generating structures spanning tens of micrometers whose mechanical properties are perfectly tuned to their fundamentally out-of-equilibrium biological function. While both individual proteins and the resulting cellular behaviors are well characterized, understanding the relationship between these two scales remains a major challenge in both physics and cell biology.
We will bridge this gap through multiscale models of the emergence of active material properties in the experimentally well-characterized actin cytoskeleton. We will thus investigate unexplored, strongly interacting nonequilibrium regimes. We will develop a complete framework for cytoskeletal activity by separately studying all three fundamental processes driving it out of equilibrium: actin filament assembly and disassembly, force exertion by branched actin networks, and the action of molecular motors. We will then recombine these approaches into a unified understanding of complex cell motility processes.
To tackle the cytoskeleton's disordered geometry and many-body interactions, we will design new nonequilibrium self consistent methods in statistical mechanics and elasticity theory. Our findings will be validated through simulations and close experimental collaborations.
Our work will break new ground in both biology and physics. In the context of biology, it will establish a new framework to understand how the cell controls its achitecture and mechanics through biochemical regulation. On the physics side, it will set up new paradigms for the emergence of original out-of-equilibrium collective behaviors in an experimentally well-characterized system, addressing the foundations of existing macroscopic 'active matter' approaches.'
year | authors and title | journal | last update |
---|---|---|---|
2017 |
Florian Rückerl, Martin Lenz, Timo Betz, John Manzi, Jean-Louis Martiel, Mahassine Safouane, Rajaa Paterski-Boujemaa, Laurent Blanchoin, Cécile Sykes Adaptive Response of Actin Bundles under Mechanical Stress published pages: 1072-1079, ISSN: 0006-3495, DOI: 10.1016/j.bpj.2017.07.017 |
Biophysical Journal 113/5 | 2019-07-08 |
2016 |
Giulia Foffano, Nicolas Levernier, Martin Lenz The dynamics of filament assembly define cytoskeletal network morphology published pages: 13827, ISSN: 2041-1723, DOI: 10.1038/ncomms13827 |
Nature Communications 7 | 2019-07-08 |
2016 |
Pierre Ronceray, Chase P. Broedersz, Martin Lenz Fiber networks amplify active stress published pages: 2827-2832, ISSN: 0027-8424, DOI: 10.1073/pnas.1514208113 |
Proceedings of the National Academy of Sciences 113/11 | 2019-07-08 |
2018 |
Cao, Luyan; Kerleau, Mikael; Suzuki, Emiko L.; Wioland, Hugo; Jouet, Sandy; Guichard, Berengere; Lenz, Martin; Romet-Lemonne, Guillaume; Jegou, Antoine Modulation of formin processivity by profilin and mechanical tension published pages: e34176, ISSN: 2050-084X, DOI: 10.1101/235333 |
eLife 7 | 2019-02-28 |
2019 |
Pierre Ronceray, Chase P. Broedersz, Martin Lenz Fiber plucking by molecular motors yields large emergent contractility in stiff biopolymer networks published pages: , ISSN: 1744-683X, DOI: 10.1039/c8sm00979a |
Soft Matter | 2019-02-28 |
2018 |
Yu Long Han, Pierre Ronceray, Guoqiang Xu, Andrea Malandrino, Roger D. Kamm, Martin Lenz, Chase P. Broedersz, Ming Guo Cell contraction induces long-ranged stress stiffening in the extracellular matrix published pages: 4075-4080, ISSN: 0027-8424, DOI: 10.1073/pnas.1722619115 |
Proceedings of the National Academy of Sciences 115/16 | 2019-02-28 |
2018 |
Ananyo Maitra, Pragya Srivastava, M. Cristina Marchetti, Juho S. Lintuvuori, Sriram Ramaswamy, Martin Lenz A nonequilibrium force can stabilize 2D active nematics published pages: 6934-6939, ISSN: 0027-8424, DOI: 10.1073/pnas.1720607115 |
Proceedings of the National Academy of Sciences 115/27 | 2019-02-28 |
2019 |
Pierre Ronceray, Chase P. Broedersz, Martin Lenz Stress-dependent amplification of active forces in nonlinear elastic media published pages: 331-338, ISSN: 1744-683X, DOI: 10.1039/c8sm00949j |
Soft Matter 15/2 | 2019-02-12 |
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The information about "MICMACTIN" are provided by the European Opendata Portal: CORDIS opendata.
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