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EPIROSE SIGNED

Self-Organising Capacity of Stem Cells during Implantation and Early Post-implantation Development: Implications for Human Development

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 EPIROSE project word cloud

Explore the words cloud of the EPIROSE project. It provides you a very rough idea of what is the project "EPIROSE" about.

lethality    functional    tissue    transformation    embryo    determinants    axes    extrapolation    congenital    molecular    photon    provides    genetically    induce    developmental    sequencing    combining    merged    reveal    global    tremendous    explore    pathological    single    shed    lineage    gap    events    regenerative    post    plan    microscopy    fill    body    fate    fundamental    outside    disorders    opportunity    screening    successive    mammalian    modeling    cells    culture    genetic    architectural    light    limitations    cellular    mother    overcome    mechanisms    initiated    medicine    inaccessibility    dimensional    event    spatio    content    specification    germ    mysterious    implanting    intertwine    temporal    employed    embryos    progresses    emergence    morphogenesis    lacking    pregnancy    decisions    intricate    engineered    stages    human    mouse    stage    transcriptional    outstanding    recapitulate    created    layers    integrate    stem    causes    despite    transformations    interactions    morphogenetic    embryonic    implantation    signaling    cell    vivo   

Project "EPIROSE" data sheet

The following table provides information about the project.

Coordinator		 THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country United Kingdom [UK]
 Project website http://zernickagoetzlab.pdn.cam.ac.uk/research.html
 Total cost 2˙477˙951 €
 EC max contribution 2˙477˙951 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2014-ADG
 Funding Scheme ERC-ADG
 Starting year 2016
 Duration (year-month-day) from 2016-01-01   to  2021-12-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 2˙477˙951.00

Map

 Project objective

Embryonic development progresses through successive cell fate decisions and intricate three-dimensional morphogenetic transformations. Implantation is the defining event in mammalian pregnancy during which a fundamental morphogenetic transformation is initiated: the body axes are established and the embryonic germ layers created. Despite its importance, a comprehensive understanding of the molecular mechanisms, transcriptional pathways, cellular interactions, as well as the spatio-temporal development of the embryo at implantation stages is at present lacking, due to the embryo’s inaccessibility. To overcome these limitations, we generated a culture system that allows the development of mouse implanting embryos outside of the mother. This system provides the opportunity to address how architectural features and signaling events integrate to induce the emergence of the body plan. Combining this new technology with the analysis of genetically engineered mouse embryos, the aim of this research proposal is to fill the knowledge gap between pre and post-implantation development. Single cell sequencing, two-photon microscopy, high-content forward genetic screening, and modeling will be merged with a functional assessment of embryo development in vivo to reveal the determinants of implantation and early post-implantation development. This global understanding will be employed to explore the extent to which stem cells can recapitulate embryonic development, with tremendous potential for regenerative medicine. Knowledge of the cellular and molecular mechanisms that intertwine lineage specification, developmental potential, and tissue morphogenesis will offer novel insight on the pathological causes of embryo lethality and congenital disorders. The proposed studies will shed light on this crucial yet mysterious stage of development in the mouse and, by extrapolation, offer outstanding potential to advance our understanding of human development.

 Publications

year authors and title journal last update
List of publications.
2018 Marta N. Shahbazi, Magdalena Zernicka-Goetz
Deconstructing and reconstructing the mouse and human early embryo
published pages: 878-887, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0144-x 		Nature Cell Biology 20/8 2020-01-23
2018 Sarah Ellys Harrison, Berna Sozen, Magdalena Zernicka-Goetz
In vitro generation of mouse polarized embryo-like structures from embryonic and trophoblast stem cells
published pages: 1586-1602, ISSN: 1754-2189, DOI: 10.1038/s41596-018-0005-x 		Nature Protocols 13/7 2020-01-23
2017 Marta N. Shahbazi, Antonio Scialdone, Natalia Skorupska, Antonia Weberling, Gaelle Recher, Meng Zhu, Agnieszka Jedrusik, Liani G. Devito, Laila Noli, Iain C. Macaulay, Christa Buecker, Yakoub Khalaf, Dusko Ilic, Thierry Voet, John C. Marioni, Magdalena Zernicka-Goetz
Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
published pages: , ISSN: 0028-0836, DOI: 10.1038/nature24675 		Nature 2020-01-23
2018 Berna Sozen, Gianluca Amadei, Andy Cox, Ran Wang, Ellen Na, Sylwia Czukiewska, Lia Chappell, Thierry Voet, Geert Michel, Naihe Jing, David M. Glover, Magdalena Zernicka-Goetz
Self-assembly of embryonic and two extra-embryonic stem cell types into gastrulating embryo-like structures
published pages: 979-989, ISSN: 1465-7392, DOI: 10.1038/s41556-018-0147-7 		Nature Cell Biology 20/8 2020-01-23

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