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PELICO SIGNED

Peptidomimetics with photocontrolled biological activity

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

PELICO project word cloud

Explore the words cloud of the PELICO project. It provides you a very rough idea of what is the project "PELICO" about.

artificial peptides idea biological expertise strategies forms biologically previously wavelength photocontrolled inactive block analogues possibility creation ones fundamental building benign anti tissues peptide compatibility exchange suitable physiologically interconvertible multidisciplinary complementary opens photo modification parties packages active convert irradiation possessing cancer amino chemotypes consists reversibly stapled therapy toxicity blocks combined microbial staff compounds emphasis evaluation drugs light exist possess natural replacing precision spatiotemporal peptidomimetics training pharmacokinetic photodynamic structure chemical basis synthesized incorporation participating breakthrough residues synthesis acid special therapeutic

Project "PELICO" data sheet

The following table provides information about the project.

Coordinator	ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE Organization address address: 78 CHERVONOTKATSKA STR. city: KYIV postcode: 2094 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Ukraine [UA]
Project website	http://pelico.org/
Total cost	688˙500 €
EC max contribution	688˙500 € (100%)
Programme	1. H2020-EU.1.3.3. (Stimulating innovation by means of cross-fertilisation of knowledge)
Code Call	H2020-MSCA-RISE-2015
Funding Scheme	MSCA-RISE
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2019-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE ENAMINE LIMITED LIABILITY COMPANY,RESEARCH AND PRODUCTION ENTERPRISE Organization address address: 78 CHERVONOTKATSKA STR. city: KYIV postcode: 2094 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UA (KYIV)	coordinator	409˙500.00
2	THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE Organization address address: TRINITY LANE THE OLD SCHOOLS city: CAMBRIDGE postcode: CB2 1TN website: www.cam.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (CAMBRIDGE)	participant	108˙000.00
3	LATVIJAS ORGANISKAS SINTEZES INSTITUTS LATVIJAS ORGANISKAS SINTEZES INSTITUTS Organization address address: AIZKRAUKLES 21 city: RIGA postcode: 1006 website: www.osi.lv contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	LV (RIGA)	participant	103˙500.00
4	KARLSRUHER INSTITUT FUER TECHNOLOGIE KARLSRUHER INSTITUT FUER TECHNOLOGIE Organization address address: KAISERSTRASSE 12 city: KARLSRUHE postcode: 76131 website: www.kit.edu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (KARLSRUHE)	participant	67˙500.00

Map

Project objective

The expertise, resources and specific knowledge of all participating parties will be combined to achieve a breakthrough in design, synthesis and application of peptide analogues (peptidomimetics) possessing photo-controlled biological activities, with special emphasis on anti-microbial and anti-cancer activities. The main idea behind the Project consists in chemical incorporation of artificial photo-controllable building blocks into known biologically active peptides by replacing their natural building blocks – the amino acid residues. Such a modification would provide photocontrolled peptidomimetics which can reversibly change their structure between two different photo-forms upon irradiation with light of different wavelength. The participating parties possess general know-how for design of the peptidomimetics which can exist in two photo-forms, biologically active and inactive ones, reversibly interconvertible by light of different wavelength. This opens a possibility to convert inactive peptidomimetics to active compounds by irradiation with physiologically benign light directly in tissues with very high spatiotemporal precision and can be a fundamental basis of new therapeutic strategies. The research staff exchange and other activities planned under the Project will be dedicated to accomplish four complementary work packages: (i) carrying out pharmacokinetic and toxicity studies of the photocontrolled peptidomimetics synthesized by the parties previously; (ii) evaluation of novel photocontrolled building block chemotypes for their compatibility with peptides; (iii) creation of new photocontrolled peptidomimetics, especially based on the novel building blocks and the know-how developed by the parties (e.g. using “stapled peptides” technology); (iv) multidisciplinary training of the researchers whose future work will be aimed at further development of the most advanced photocontrolled peptidomimetics as drugs suitable for photodynamic therapy.

Deliverables

List of deliverables.
Reports on biological activity studies	Documents, reports	2020-03-20 15:18:12
Novel photocontrollable building blocks	Other	2020-03-20 15:18:12
manuscript 4	Documents, reports	2020-03-20 15:18:12
Manuscript 2	Documents, reports	2020-03-20 15:18:12
Manuscript 3	Documents, reports	2020-03-20 15:18:12
Manuscript 1	Documents, reports	2020-03-20 15:18:12
Project web-site	Websites, patent fillings, videos etc.	2020-03-20 15:18:12

Take a look to the deliverables list in detail: detailed list of PELICO deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2020	Oleg Babii, Sergii Afonin, Tim Schober, Liudmyla V Garmanchuk, Liudmyla I Ostapchenko, Volodymyr Yurchenko, Sergey Zozulya, Oleksandr Tarasov, Iryna Pishel, Anne S Ulrich, Igor V Komarov Peptide drugs for photopharmacology: how much of a safety advantage can be gained by photocontrol? published pages: , ISSN: 2631-3316, DOI: 10.4155/fdd-2019-0033	Future Drug Discovery	2020-03-20
2020	Sergii Afonin, Oleg Babii, Aline Reuter, Volker Middel, Masanari Takamiya, Uwe StrÃ¤hle, Igor V Komarov, Anne S Ulrich Light-controllable dithienylethene-modified cyclic peptides: photoswitching the in vivo toxicity in zebrafish embryos published pages: 39-49, ISSN: 1860-5397, DOI: 10.3762/bjoc.16.6	Beilstein Journal of Organic Chemistry 16	2020-03-20
2019	Tim Schober, Ilona Wehl, Sergii Afonin, Oleg Babii, Anna Iampolska, Ute Schepers, Igor V. Komarov, Anne S. Ulrich Controlling the Uptake of Diaryletheneâ€Based Cellâ€Penetrating Peptides into Cells Using Light published pages: , ISSN: 2367-0932, DOI: 10.1002/cptc.201900019	ChemPhotoChem	2020-03-20
2018	Alexander V. Strizhak, Krishna Sharma, Oleg Babii, Sergii Afonin, Anne S. Ulrich, Igor V. Komarov, David R. Spring Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking published pages: , ISSN: 1477-0520, DOI: 10.1039/c8ob02428f	Organic & Biomolecular Chemistry	2020-03-20
2018	Oleg Babii, Sergii Afonin, Aleksandr Yu. Ishchenko, Tim Schober, Anatoliy O. Negelia, Ganna M. Tolstanova, Liudmyla V. Garmanchuk, Liudmyla I. Ostapchenko, Igor V. Komarov, Anne S. Ulrich Structureâ€“Activity Relationships of Photoswitchable Diarylethene-Based Î²-Hairpin Peptides as Membranolytic Antimicrobial and Anticancer Agents published pages: 10793-10813, ISSN: 0022-2623, DOI: 10.1021/acs.jmedchem.8b01428	Journal of Medicinal Chemistry 61/23	2020-03-20
2017	Oleg Babii, Sergii Afonin, Tim Schober, Igor V. Komarov, Anne S. Ulrich Flexibility vs rigidity of amphipathic peptide conjugates when interacting with lipid bilayers published pages: 2505-2515, ISSN: 0005-2736, DOI: 10.1016/j.bbamem.2017.09.021	Biochimica et Biophysica Acta (BBA) - Biomembranes 1859/12	2020-03-20

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The information about "PELICO" are provided by the European Opendata Portal: CORDIS opendata.