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FOLSMART SIGNED

Folate-Target Nanodevices To Activated Macrophages For Rheumatoid Arthritis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FOLSMART project word cloud

Explore the words cloud of the FOLSMART project. It provides you a very rough idea of what is the project "FOLSMART" about.

nanoparticles ph indication bench validate trials marked intolerant release mtx temperature biological unresponsive nanodevices technological acid folsmart genotoxicity domain tolerability neck sulfasalazine optimization business tolerance elaborated encapsulating efficacy showed scores line initial peptide clinical carcinogenicity methotrexate animal toxicology drugs pharmacokinetics alternatives patients folic macrophages mechanisms treatments fbn fa laboratory mediated hsa good rat health therapy sensitive parallel agent therapies nanofol glp hospital drug folate dog mouse performed economic ra arthritis models conjugates tested manufacturing liposomal poses rheumatoid gmp standards positively activated model benchmarked treatment benefit first plans burden fp7 toxicity evaluation ssz claims public marketed

Project "FOLSMART" data sheet

The following table provides information about the project.

Coordinator	ASSOCIACAO UNIVERSIDADE EMPRESA PARA DESENVOLVIMENTO TECMINHO Organization address address: CAMPUS DE AZUREM UNIVERSIDADE DO MINHO city: GUIMARAES postcode: 4800 058 website: www.tecminho.uminho.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Portugal [PT]
Project website	http://www.folsmart.net
Total cost	4˙993˙833 €
EC max contribution	4˙993˙833 € (100%)
Programme	1. H2020-EU.2.1.2.2. (Ensuring the safe and sustainable development and application of nanotechnologies) 2. H2020-EU.2.1.2.5. (Developing and standardisation of capacity-enhancing techniques, measuring methods and equipment) 3. H2020-EU.2.1.2.3. (Developing the societal dimension of nanotechnology)
Code Call	H2020-NMP-PILOTS-2015
Funding Scheme	RIA
Starting year	2016
Duration (year-month-day)	from 2016-01-01 to 2020-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ASSOCIACAO UNIVERSIDADE EMPRESA PARA DESENVOLVIMENTO TECMINHO ASSOCIACAO UNIVERSIDADE EMPRESA PARA DESENVOLVIMENTO TECMINHO Organization address address: CAMPUS DE AZUREM UNIVERSIDADE DO MINHO city: GUIMARAES postcode: 4800 058 website: www.tecminho.uminho.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (GUIMARAES)	coordinator	1˙142˙037.00
2	BLUECLINICAL - INVESTIGACAO E DESENVOLVIMENTO EM SAUDE LDA BLUECLINICAL - INVESTIGACAO E DESENVOLVIMENTO EM SAUDE LDA Organization address address: AVENIDA VILLAGARCIA DE AROSA 1919 1 city: MOTOSINHOS postcode: 4460 439 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (MOTOSINHOS)	participant	629˙845.00
3	APTUIT (VERONA) SRL APTUIT (VERONA) SRL Organization address address: VIA ALESSANDRO FLEMING 4 city: VERONA postcode: 37135 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (VERONA)	participant	544˙440.00
4	INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE Organization address address: RUE DE TOLBIAC 101 city: PARIS postcode: 75654 website: www.inserm.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PARIS)	participant	488˙400.00
5	INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC INSTITUTO DE BIOLOGIA MOLECULAR E CELULAR-IBMC Organization address address: RUA ALFREDO ALLEN 208 city: PORTO postcode: 4200 135 website: www.ibmc.up.pt contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (PORTO)	participant	436˙823.00
6	MEDIZINISCHE UNIVERSITAET WIEN MEDIZINISCHE UNIVERSITAET WIEN Organization address address: SPITALGASSE 23 city: WIEN postcode: 1090 website: www.meduniwien.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	404˙510.00
7	UNIVERSITAET FUER BODENKULTUR WIEN UNIVERSITAET FUER BODENKULTUR WIEN Organization address address: GREGOR MENDEL STRASSE 33 city: WIEN postcode: 1180 website: www.boku.ac.at contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	AT (WIEN)	participant	399˙556.00
8	BLUEPHARMA - INDUSTRIA FARMACEUTICASA BLUEPHARMA - INDUSTRIA FARMACEUTICASA Organization address address: SAO MARTINHO DO BISPO city: COIMBRA postcode: 3045 016 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (COIMBRA)	participant	327˙671.00
9	SOLFARCOS - SOLUÇÕES FARMACÊUTICAS E COSMÉTICAS LDA SOLFARCOS - SOLUÇÕES FARMACÊUTICAS E COSMÉTICAS LDA Organization address address: CENTRO DE ENGENHARIA BIOLOGICA - ESCOLA DE ENGENHA VERSIDADE DO MINHO CAMPUS DE GUALTAR city: BRAGA postcode: 4710 057 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	PT (BRAGA)	participant	311˙675.00
10	SYNOVO GMBH SYNOVO GMBH Organization address address: Paul Ehrlich Str 15 city: TUEBINGEN postcode: 72076 website: www.synovo.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (TUEBINGEN)	participant	300˙000.00
11	GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG GABO:MI GESELLSCHAFT FUR ABLAUFORGANISATION:MILLIARIUM MBH & CO KG Organization address address: OSKAR VON MILLER RING 29 city: MUENCHEN postcode: 80333 website: www.gabo-mi.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (MUENCHEN)	participant	8˙875.00

Map

Project objective

FOLSMART will bring to phase I clinical trials novel folate-based nanodevices (FBN) for the treatment of rheumatoid arthritis (RA). These nanodevices for folic acid (FA)-mediated targeting of activated macrophages showed improved clinical scores in a mouse model of RA when compared to methotrexate (MTX), a first-line drug therapy for the treatment of RA. In this way, FBN will be benchmarked against this drug. MTX has significant associated toxicity and second line biological therapies poses a great economic burden to hospital/public health systems. In parallel, nanodevices encapsulating Sulfasalazine (SSZ), will be tested. SSZ is a second line indication for the treatment of RA, unresponsive to MTX or MTX–intolerant patients. Furthermore, FOLSMART propose the optimization of mechanisms for the release of the drugs, through pH and temperature sensitive nanodevices. An exploitation and business plans will be elaborated. In parallel, initial economic evaluation of all proposed treatments will be performed to validate these claims.

Specific technological objectives of FOLSMART will be:

Good Manufacturing Practice (GMP) production of the FBN based therapies which have been positively bench-marked in the previous FP7 European project NANOFOL in comparison with the use of MTX in a RA mouse model: -Liposomal MTX and SSZ with FA-“neck domain” peptide as targeting agent -Nanoparticles from HSA-FA/MTX conjugates and SSZ -Optimization of mechanisms of drug release and application to other fields

Pre-clinical development on RA models -Toxicology and pharmacokinetics, to determine tolerability and efficacy benefit in two animal models rat and dog, under Good Laboratory Practice (GLP) standards -Genotoxicity and Carcinogenicity

Phase I clinical trials of the best therapies bench marketed against MTX -Nanodevices with MTX and SSZ will offer improved tolerance and greater efficacy meaning that patients who do not do well on MTX will have cost-effective alternatives

Deliverables

List of deliverables.
Exploitation activity - yearly report 2 in knowledge subjected of protection	Documents, reports	2020-04-07 20:48:06
Dissemination plan revised	Websites, patent fillings, videos etc.	2020-04-07 20:48:06
Exploitation activity - yearly report 3 in knowledge subjected of protection	Documents, reports	2020-04-07 20:48:06
Individualized press release for every partner	Documents, reports	2020-04-07 20:48:05
Design of the logo, Launch of website, Twitter, Facebook, LinkedIn, Google Plus	Documents, reports	2020-04-07 20:48:05
Plan and formal distribution of essential internal procedures and tools	Documents, reports	2020-04-07 20:48:05
Exploitation activity - yearly report 1 in knowledge subjected of protection	Documents, reports	2020-04-07 20:48:05

Take a look to the deliverables list in detail: detailed list of FOLSMART deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Claudia Tallian, Alexandra Herrero-Rollett, Karina Stadler, Robert Vielnascher, Karin Wieland, Anna M. Weihs, Alessandro Pellis, Andreas H. Teuschl, Bernhard Lendl, Heinz Amenitsch, Georg M. Guebitz Structural insights into pH-responsive drug release of self-assembling human serum albumin-silk fibroin nanocapsules published pages: 176-187, ISSN: 0939-6411, DOI: 10.1016/j.ejpb.2018.10.002	European Journal of Pharmaceutics and Biopharmaceutics 133	2020-04-07
2018	EugÃ©nia Nogueira, Marisa P. SÃ¡rria, Nuno G. Azoia, Egipto Antunes, Ana Loureiro, Diana GuimarÃ£es, Jennifer Noro, Alexandra Rollett, Georg Guebitz, Artur Cavaco-Paulo Internalization of Methotrexate Conjugates by Folate Receptor-Î± published pages: 6780-6786, ISSN: 0006-2960, DOI: 10.1021/acs.biochem.8b00607	Biochemistry 57/49	2020-04-07
2018	Nogueira, EugÃ©nia Sofia Costa; Cavaco-Paulo, Artur Folate-targeted liposomes for rheumatoid arthritis therapy published pages: 43, ISSN: , DOI:	Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patientsâ€™ needs	2020-04-07
2018	Loureiro, Ana Isabel SÃ¡; Cavaco-Paulo, Artur Folic acid-tagged protein nanoemulsions with controllable size for cancer therapy published pages: 105, ISSN: , DOI:	Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patientsâ€™ needs 2	2020-04-07
2018	Tallian, C., Herrero-Rollett, A., Stadler, K., Vielnascher, R., Wieland, K., Weihs, A. M., Teuschl, A. H., Lendl, B., Amenitsch, H, Guebitz, G. M. Structural insights in modified HSA-SF nanocapsules for targeted drug delivery in rheumatoid arthritis therapy published pages: 14, ISSN: , DOI:	Book of Abstracts of the 6th DocDay 2018	2020-04-07
2018	Anna Ohradanova-Repic, EugÃ©nia Nogueira, Ingrid Hartl, Andreia C. Gomes, Ana Preto, Eva Steinhuber, Vanessa MÃ¼hlgrabner, Marko Repic, Mario Kuttke, Alexander Zwirzitz, Marek Prouza, Miloslav Suchanek, Gordana Wozniak-Knopp, Vaclav Horejsi, Gernot Schabbauer, Artur Cavaco-Paulo, Hannes Stockinger Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells published pages: 123-130, ISSN: 1549-9634, DOI: 10.1016/j.nano.2017.09.003	Nanomedicine: Nanotechnology, Biology and Medicine 14/1	2020-04-07
2018	Diana GuimarÃ£es, EugÃ©nia Nogueira, Artur Cavaco-Paulo Effect of sucrose in freeze-dried liposomes encapsulating drugs published pages: 80, ISSN: , DOI:	Abstract Book of the XII Spanish-Portuguese Conference on Controlled Drug Delivery - Tailoring drug delivery systems to the patientsâ€™ needs	2020-04-07
2018	Elisabeth Dietersdorfer, Alexander Kirschner, Barbara Schrammel, Anna Ohradanova-Repic, Hannes Stockinger, Regina Sommer, Julia Walochnik, SÃlvia Cervero-AragÃ³ Starved viable but non-culturable (VBNC) Legionella strains can infect and replicate in amoebae and human macrophages published pages: 428-438, ISSN: 0043-1354, DOI: 10.1016/j.watres.2018.01.058	Water Research 141	2020-04-07
2018	Jennifer Noro, Rui L. Reis, Artur Cavaco-Paulo, Carla Silva Ultrasound-assisted biosynthesis of novel methotrexate-conjugates published pages: 51-56, ISSN: 1350-4177, DOI: 10.1016/j.ultsonch.2018.05.017	Ultrasonics Sonochemistry 48	2020-04-07
2018	Ana Loureiro, Jennifer Noro, Ana S. Abreu, EugÃ©nia Nogueira, Diana Soares da Costa, Carla Silva, Artur Cavaco-Paulo Absence of Albumin Improves in Vitro Cellular Uptake and Disruption of Poloxamer 407-Based Nanoparticles inside Cancer Cells published pages: 527-535, ISSN: 1543-8384, DOI: 10.1021/acs.molpharmaceut.7b00893	Molecular Pharmaceutics 15/2	2020-04-07
2018	Alexander Zwirzitz, Michael Reiter, Rostislav Skrabana, Anna Ohradanova-Repic, Otto Majdic, Marianna Gutekova, Ondrej Cehlar, Eva PetrovÄÃkovÃ¡, Eva Kutejova, Gerold Stanek, Hannes Stockinger, Vladimir Leksa Lactoferrin is a natural inhibitor of plasminogen activation published pages: 8600-8613, ISSN: 0021-9258, DOI: 10.1074/jbc.ra118.003145	Journal of Biological Chemistry 293/22	2020-04-07
2017	Johannes J. Kovarik, Elisabeth Kernbauer, Markus A. HÃ¶lzl, Johannes Hofer, Guido A. Gualdoni, Klaus G. Schmetterer, Fitore Miftari, Yury Sobanov, Anastasia Meshcheryakova, Diana Mechtcheriakova, Nadine Witzeneder, Georg Greiner, Anna Ohradanova-Repic, Petra Waidhofer-SÃ¶llner, Marcus D. SÃ¤emann, Thomas Decker, Gerhard J. Zlabinger Fasting metabolism modulates the interleukin-12/interleukin-10 cytokine axis published pages: e0180900, ISSN: 1932-6203, DOI: 10.1371/journal.pone.0180900	PLOS ONE 12/7	2020-04-07
2018	Anna Ohradanova-Repic, Christian Machacek, Celine Charvet, Franck Lager, Delphine Le Roux, RenÃ© Platzer, Vladimir Leksa, Goran Mitulovic, Thomas R. Burkard, Gerhard J. Zlabinger, Michael B. Fischer, Vincent Feuillet, Gilles Renault, Stephan BlÃ¼ml, Miroslav Benko, Miloslav Suchanek, Johannes B. Huppa, Takami Matsuyama, Artur Cavaco-Paulo, Georges Bismuth, Hannes Stockinger Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances published pages: , ISSN: 1664-3224, DOI: 10.3389/fimmu.2018.00852	Frontiers in Immunology 9	2020-04-07
2017	Verena Supper, Ingrid Hartl, Cyril BoulÃ¨gue, Anna Ohradanova-Repic, Hannes Stockinger Dynamic Interaction- and Phospho-Proteomics Reveal Lck as a Major Signaling Hub of CD147 in T Cells published pages: 2468-2478, ISSN: 0022-1767, DOI: 10.4049/jimmunol.1600355	The Journal of Immunology 198/6	2020-04-07
2017	C. Tallian Development of protein-based stimuli responsive drug delivery systems published pages: , ISSN: , DOI:	Functional biomaterials & enzymes symposium	2020-04-07
2017	C. Tallian, A. Herrero-Rollett, G. Tegl, D. Huber, L. Gutmann, R. Vielnascher and G.M. Guebitz Release studies of stimuli-responsive modified HSA microcapsules for targeted drug delivery published pages: , ISSN: , DOI:	BioNanoMed	2020-04-07
2017	Claudia Tallian, Karina Stadler, Lisa Gutmann, Alexandra Herrero-Rollett and Georg M. Guebitz Development of protein-based targeted drug delivery systems published pages: , ISSN: , DOI:	Designer Biology	2020-04-07

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