TraumiR SIGNED
microRNAs in susceptibility to traumatic stress
Total Cost €
0EC-Contrib. €
0Partnership
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0TraumiR project word cloud
Explore the words cloud of the TraumiR project. It provides you a very rough idea of what is the project "TraumiR" about.
Project "TraumiR" data sheet
The following table provides information about the project.
| Coordinator |
UNIVERSITEIT MAASTRICHT
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Project website | https://www.ecnp.eu/presentationpdfs/71/P.4.a.009.pdf |
| Total cost | 177˙598 € |
| EC max contribution | 177˙598 € (100%) |
| Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
| Code Call | H2020-MSCA-IF-2015 |
| Funding Scheme | MSCA-IF-EF-ST |
| Starting year | 2016 |
| Duration (year-month-day) | from 2016-06-01 to 2018-05-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | UNIVERSITEIT MAASTRICHT | NL (MAASTRICHT) | coordinator | 177˙598.00 |
Map
Project objective
Traumatic stressors are important and prevalent risk factors for psychiatric disorders, such as post-traumatic stress disorder (PTSD). People differ strikingly in their susceptibility to develop PTSD after traumatic stress, however the exact underlying biological mechanisms of differential susceptibility are unknown. The identification of biomarkers that distinguish between persons at high and low risk of developing PTSD following trauma exposure would enable more effective preventive strategies and early interventions. Epigenetic mechanisms have been proposed to underlie the relationship between exposure to traumatic stress and the susceptibility to develop PTSD. Recent work carried out by the host laboratory demonstrated that DNA methylation might regulate the impact of traumatic stress on gene expression and ultimately brain function. Based on this and the emerging role of miRNA as key epigenetic players in psychiatric disorders, I hypothesize that (i) susceptibility to traumatic stress exposure is associated with distinct miRNAs expression profiles with blood-brain correlation, (ii) experimental manipulation of miRNA expression levels in animals alters their susceptibility to traumatic stress. These hypotheses will be tested by a unique set of epigenetic epidemiological studies using prospective cohorts with longitudinal sampling schemes of military soldiers deployed to war, next to experimental animal studies. The proposed multidisciplinary and translational project will open the possibility of tapping into the mechanisms underlying differential susceptibility to traumatic stress through blood profiling. It has excellent prospects for yielding clinically relevant and usable biomarkers for the prediction of susceptibility to traumatic stressors. Moreover, the project will reinforce my foundation as a highly promising early career researcher by broadening my knowledge, skills, professional experience and network necessary to launch my own research group.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Clara Snijders, Laurence de Nijs, Dewleen G. Baker, Richard L. Hauger, Daniel van den Hove, Gunter Kenis, Caroline M. Nievergelt, Marco P. Boks, Eric Vermetten, Fred H. Gage, Bart P.F. Rutten MicroRNAs in Post-traumatic Stress Disorder published pages: , ISSN: , DOI: 10.1007/7854_2017_32 |
Current Topics in Behavioral Neurosciences | 2019-06-13 |
| 2018 |
Sillivan, S.E.
Jamieson, S.
de Nijs, L.
Jones, M.
Snijders, C.
Klengel, T.
Joseph, N.F.
Krauskopf, J.
Kleinjans, J.
Vinkers, C.H.
Boks, M.P.M.
Geuze, E.
Vermetten, E.
Ressler, K.J.
Rutten, B.P.F.
Rumbaugh, G.
Miller C.A. microRNA regulation of persistent stress-enhanced memory published pages: , ISSN: 1095-9203, DOI: |
Science | 2019-06-13 |
| 2017 |
L. De Nijs, J. Krauskopf, C. Snijders, J. Kleinjans, B. Machiels, B. Smeets, G. Kenis, D. Van den Hove, C. Vinkers, E. Geuze, M. Boks, E. Vermetten, B. Rutten Alterations in Blood-based miRNA in Veterans Affected with Combat-related PTSD published pages: , ISSN: , DOI: |
2019-06-13 | |
| 2017 |
L. De Nijs, J. Krauskopf, C. Snijders, J. Kleinjans, B. Machiels, B. Smeets, G. Kenis, D. Van den Hove, C. Vinkers, E. Geuze, M. Boks, E. Vermetten, B. Rutten Circulating microRNAs as potential biomarkers of differential susceptibility to traumatic stress published pages: S986-S987, ISSN: 0924-977X, DOI: 10.1016/S0924-977X(17)31736-4 |
European Neuropsychopharmacology 27 | 2019-06-13 |
| 2017 |
Laurence de Nijs, Julian Krauskopf, Jos Kleinjans, Barbie Machiels, Clara Snijders, Bert Smeets, Gunter Kenis, Daniel van den Hove, Christiaan Vinkers, Elbert Geuze, Marco Boks, Eric Vermetten, Bart Rutten 503. Circulating microRNAs as Potential Biomarkers of Differential Susceptibility to Traumatic Stress published pages: S204-S205, ISSN: 0006-3223, DOI: 10.1016/j.biopsych.2017.02.1111 |
Biological Psychiatry 81/10 | 2019-06-13 |
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