Explore the words cloud of the BOOST project. It provides you a very rough idea of what is the project "BOOST" about.
The following table provides information about the project.
Coordinator |
POLITECNICO DI TORINO
Organization address contact info |
Coordinator Country | Italy [IT] |
Project website | http://www.ercprojectboost.eu/ |
Total cost | 1˙977˙500 € |
EC max contribution | 1˙977˙500 € (100%) |
Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
Code Call | ERC-2015-CoG |
Funding Scheme | ERC-COG |
Starting year | 2016 |
Duration (year-month-day) | from 2016-05-01 to 2021-12-31 |
Take a look of project's partnership.
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1 | POLITECNICO DI TORINO | IT (TORINO) | coordinator | 1˙977˙500.00 |
One out of 5 people in their fifties will experience a bone fracture due to osteoporosis (OP)-induced fragility in their lifetime. The OP socio-economic burden is dramatic and involves tens of millions of people in the EU, with a steadily increasing number due to population ageing. Current treatments entail drug-therapy coupled with a healthy lifestyle but OP fractures need mechanical fixation to rapidly achieve union: the contribution of biomaterial scientists in this field is still far from taking its expected leading role in cutting-edge research. Bone remodelling is a well-coordinated process of bone resorption by osteoclasts followed by the production of new bone by osteoblasts. This process occurs continuously throughout life in a coupling with a positive balance during growth and negative with ageing, which can result in OP. We believe that an architecture driven stimulation of the osteoclast/osteoblast coupling, with an avant-garde focus on osteoclasts activity, is the key to success in treating unbalanced bone remodelling. We aim to manufacture a scaffold that mimics healthy bone features which will establish a new microenvironment favoring a properly stimulated and active population of osteoclasts and osteoblasts, i.e. a well-balanced bone cooperation. After 5 years we will be able to prove the efficacy of this approach. A benchmark will be set up for OP fracture treatment and for the realization of smart bone substitutes that will be able to locally “trick” aged bone cells stimulating them to act as healthy ones. BOOST results will have an unprecedented impact on the scientific research community, opening a new approach to set up smart, biomimetic strategies to treat aged, unbalanced bone tissues and to reduce OP-associated disabilities and financial burdens.
year | authors and title | journal | last update |
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2020 |
Giorgia Montalbano, Giulia Molino, Sonia Fiorilli, Chiara Vitale-Brovarone Synthesis and incorporation of rod-like nano-hydroxyapatite into type I collagen matrix: A hybrid formulation for 3D printing of bone scaffolds published pages: , ISSN: 0955-2219, DOI: 10.1016/j.jeurceramsoc.2020.02.018 |
Journal of the European Ceramic Society | 2020-04-24 |
2019 |
Giorgia Montalbano, Giorgia Borciani, Carlotta Pontremoli, Gabriela Ciapetti, Monica Mattioli-Belmonte, Sonia Fiorilli, Chiara Vitale-Brovarone Development and Biocompatibility of Collagen-Based Composites Enriched with Nanoparticles of Strontium Containing Mesoporous Glass published pages: 3719, ISSN: 1996-1944, DOI: 10.3390/ma12223719 |
Materials 12/22 | 2020-04-24 |
2020 |
Giulia Molino, Maria Chiara Palmieri, Giorgia Montalbano, Sonia Fiorilli, Chiara Vitale-Brovarone Biomimetic and mesoporous nano-hydroxyapatite for bone tissue application: a short review published pages: 22001, ISSN: 1748-605X, DOI: 10.1088/1748-605X/ab5f1a |
Biomedical Materials 15/2 | 2020-04-24 |
2019 |
Giulia Molino, Alessio Dalpozzi, Gabriela Ciapetti, Massimo Lorusso, Chiara Novara, Marco Cavallo, Nicola Baldini, Fabrizio Giorgis, Sonia Fiorilli, Chiara Vitale-Brovarone Osteoporosis-related variations of trabecular bone properties of proximal human humeral heads at different scale lengths published pages: 103373, ISSN: 1751-6161, DOI: 10.1016/j.jmbbm.2019.103373 |
Journal of the Mechanical Behavior of Biomedical Materials 100 | 2020-04-24 |
2017 |
Alessandra Bari, Nora Bloise, Sonia Fiorilli, Giorgia Novajra, Maria Vallet-RegÃ, Giovanna Bruni, Almudena Torres-Pardo, José M. González-Calbet, Livia Visai, Chiara Vitale-Brovarone Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration published pages: 493-504, ISSN: 1742-7061, DOI: 10.1016/j.actbio.2017.04.012 |
Acta Biomaterialia 55 | 2019-06-18 |
2017 |
Francesco Baino, Sonia Fiorilli, Chiara Vitale-Brovarone Composite Biomaterials Based on Sol-Gel Mesoporous Silicate Glasses: A Review published pages: 15, ISSN: 2306-5354, DOI: 10.3390/bioengineering4010015 |
Bioengineering 4/1 | 2019-06-18 |
2018 |
Alessandra Bari, Giulia Molino, Sonia Fiorilli, Chiara Vitale-Brovarone Novel multifunctional strontium-copper co-substituted mesoporous bioactive particles published pages: 37-40, ISSN: 0167-577X, DOI: 10.1016/j.matlet.2018.04.006 |
Materials Letters 223 | 2019-05-28 |
2018 |
Sonia Fiorilli, Giulia Molino, Carlotta Pontremoli, Giorgio Iviglia, Elisa Torre, Clara Cassinelli, Marco Morra, Chiara Vitale-Brovarone The Incorporation of Strontium to Improve Bone-Regeneration Ability of Mesoporous Bioactive Glasses published pages: 678, ISSN: 1996-1944, DOI: 10.3390/ma11050678 |
Materials 11/5 | 2019-05-28 |
2018 |
Giorgia Montalbano, Sonia Fiorilli, Andrea Caneschi, Chiara Vitale-Brovarone Type I Collagen and Strontium-Containing Mesoporous Glass Particles as Hybrid Material for 3D Printing of Bone-Like Materials published pages: 700, ISSN: 1996-1944, DOI: 10.3390/ma11050700 |
Materials 11/5 | 2019-05-28 |
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