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SMART-BONE SIGNED

Smart electroactive 3D models of osteoregeneration

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SMART-BONE project word cloud

Explore the words cloud of the SMART-BONE project. It provides you a very rough idea of what is the project "SMART-BONE" about.

templating worldwide vitro sustaining successfully life fill fractures differentiation electrochemical technique projected ice ncscs preserving potentialities differentiate healing annual device defect neural expectancy beneficial novelty electrical monitoring donors cells model retain label stimulus organic extracted million 3d efficacy answer stimulation prepared tools electronic multiple free positively defects adult size patient grafts alone stem transistor 2025 biocompatible vessels union forming readout implant prove oect aging external critical isolated fracture reported material crest scaffolds population human electrically bone cell remarkable despite altogether lineages graft shown stimulated implants electroactive

Project "SMART-BONE" data sheet

The following table provides information about the project.

Coordinator	INSTITUT MINES-TELECOM There are not information about this coordinator. Please contact Fabio for more information, thanks.
Coordinator Country	France [FR]
Project website	https://www.ceb.cam.ac.uk/research/groups/best/people
Total cost	173˙076 €
EC max contribution	173˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-09-01 to 2018-08-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	INSTITUT MINES-TELECOM INSTITUT MINES-TELECOM Organization address address: 19 PLACE MARGUERITE PEREY city: PALAISEAU postcode: 91120 website: www.institut-telecom.fr contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (PALAISEAU)	coordinator	173˙076.00
2	ECOLE NATIONALE SUPERIEURE DES MINES DE SAINT-ETIENNE ECOLE NATIONALE SUPERIEURE DES MINES DE SAINT-ETIENNE Organization address address: COURS FAURIEL 158 city: SAINT ETIENNE CEDEX postcode: 42023 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (SAINT ETIENNE CEDEX)	coordinator	0.00

Map

Project objective

In the European Union alone, the annual number of bone fractures is projected to reach 4.5 million in 2025. Despite the advances in implant technology, grafts prepared using bone extracted from the patient to fill the bone defect are the only material reported so far to retain any significant efficacy in sustaining new bone formation. However, the aging worldwide population and increased life expectancy call for a different answer to the growing need for effective implants for bone fracture healing. The 3D-BONE project will develop an in vitro 3D model to investigate electrical stimulation of stem cells based on biocompatible electroactive 3D scaffolds produced by the ice-templating technique. Electrical stimulation has been shown to positively affect stem cells differentiation into both bone- and vessels-forming cells. One of the key novelty of the 3D-BONE project is the use of human neural crest-derived stem cells (NCSCs). The study of this system in vitro will contribute to increasing the knowledge on a cell population that has the remarkable characteristic of preserving their potentialities to differentiate towards multiple lineages also in the adult. They can thus be isolated from the patient in need of the bone graft, with no need of external donors. Cells’ response to the applied electrical stimulus will be investigated using an organic electrochemical transistor (OECT) that will be integrated in the developed device and will allow for label-free monitoring of cells through an electronic readout. Altogether, the results of these studies will prove beneficial to increase the knowledge on electrically stimulated stem cells differentiation, providing new key tools for the development of implants to be successfully used in critical size defects healing.

Publications

List of publications.
year	authors and title	journal	last update
2018	Donata Iandolo, Fabrizio A. Pennacchio, Valentina Mollo, Domenico Rossi, David Dannhauser, Bianxiao Cui, Roisin M. Owens, Francesca Santoro Electron Microscopy for 3D Scaffolds-Cell Biointerface Characterization published pages: 1800103, ISSN: 2366-7478, DOI: 10.1002/adbi.201800103	Advanced Biosystems	2019-05-27

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The information about "SMART-BONE" are provided by the European Opendata Portal: CORDIS opendata.