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FIBROCAN TERMINATED

Defining the immunological interplay between fibroblastic reticular cells and anti-tumour T cells

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

FIBROCAN project word cloud

Explore the words cloud of the FIBROCAN project. It provides you a very rough idea of what is the project "FIBROCAN" about.

hypothesis nodes robustly reactivity provides biology shut effector immunotherapies cells disciplinary lasting contribution fundamental metastatic self time cancer first fibroblastic progression lymph initiated stromal preventing designed acquiring defines cell suppression paradoxically systematically mechanisms fibrocan immune frcs sites presentation deleting opportunity charting tumour frontier immunology antigen vitro vivo inform tolerated anti functions reticular

Project "FIBROCAN" data sheet

The following table provides information about the project.

Coordinator	THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://lnscgroup.net/
Total cost	195˙454 €
EC max contribution	195˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2015
Funding Scheme	MSCA-IF-EF-ST
Starting year	2016
Duration (year-month-day)	from 2016-07-01 to 2018-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	THE UNIVERSITY OF BIRMINGHAM THE UNIVERSITY OF BIRMINGHAM Organization address address: Edgbaston city: BIRMINGHAM postcode: B15 2TT website: www.bham.ac.uk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (BIRMINGHAM)	coordinator	195˙454.00

Map

Project objective

Lymph nodes are sites where immune responses are robustly initiated. Paradoxically, they are also very common metastatic sites, where tumour progression is well-tolerated. Robust evidence defines a role for fibroblastic reticular cells (FRCs) in preventing T cells from acquiring effector functions within lymph nodes, and deleting T cells that show self-reactivity. FIBROCAN will test the hypothesis that FRCs systematically shut down anti-tumour T cell responses, testing mechanisms of suppression in vitro and in vivo, and charting tumour antigen presentation by FRCs to T cells for the first time.

At the frontier of stromal immunology and cancer biology, FIBROCAN was been designed to inform our fundamental understanding of metastatic cancer progression, particularly relevant to the implementation and design of T cell immunotherapies. This project provides the opportunity for a lasting and multi-disciplinary contribution in the high impact fields of stromal and cancer immunology.

Publications

List of publications.
year	authors and title	journal	last update
2016	K Knoblich, SM-L Siew, B Parekkadan, S Turley, A Fletcher Abstracts of ICI 2016 International Congress of Immunology, 21-26 August 2016, Melbourne, Australia published pages: 1-1274, ISSN: 0014-2980, DOI: 10.1002/eji.201670200	European Journal of Immunology 46	2019-06-13

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The information about "FIBROCAN" are provided by the European Opendata Portal: CORDIS opendata.