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SensoNMDA SIGNED

Impact of NMDA receptor diversity in sensory information processing

Total Cost €

0

EC-Contrib. €

0

Partnership

0

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 SensoNMDA project word cloud

Explore the words cloud of the SensoNMDA project. It provides you a very rough idea of what is the project "SensoNMDA" about.

synapses    somatosensory    nmdar    relevance    variability    genetic    consequence    context    stimulation    strategies    tools    inhibitory    functional    excitatory    computation    adult    glutamatergic    imaging    neurons    cortical    thought    stimuli    despite    highlighted    densities    primary    remarkable    diversity    connections    sensory    computations    capacities    combination    composition    shaping    compute    fundamental    array    relative    techniques    modulators    signal    tuning    neuronal    receptors    electrophysiology    shapes    electrophysiological    varies    poorly    heterogeneity    subunit    model    mostly    endogenous    plan    optogenetic    vivo    demonstrating    synaptic    biophysical    brain    neuron    broad    s1    considerably    influenced    data    computational    cortex    possibility    original    question    plasticity    relationship    reveal    dendritic    interneurons    documented    simulations    decompose    photon    density    integration    nmdars    plays    pharmacological    single    recruitment    provides    nmda   

Project "SensoNMDA" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙200˙000 €
 EC max contribution 1˙200˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙200˙000.00

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 Project objective

Synaptic variability between neuronal connections is thought to contribute to brain’s remarkable information processing capacities. In the adult brain, the density as well as subunit composition of synaptic NMDA receptors (NMDARs) varies considerably between synapses and between neurons. Despite the well documented heterogeneity of NMDARs the functional relevance of such diversity is poorly known. In the past, the functional relevance of such NMDAR diversity has been mostly considered in the context of neuronal development and long-term synaptic plasticity. Model simulations have highlighted that dendritic computations are strongly influenced by synaptic NMDARs densities and biophysical properties. Here I propose to directly study the consequence of NMDAR diversity in shaping integration properties of single neurons in primary somatosensory cortex (S1). To achieve this I will decompose this broad question into three specific tasks. 1-Assessment of NMDAR heterogeneity in glutamatergic neurons and study how this variability shapes dendritic integration. 2-Study the impact of NMDARs in signal computation among cortical interneurons. 3-Investigate the functional relationship between endogenous NMDAR modulators and NMDAR diversity. I plan to use an array of genetic, optogenetic and pharmacological tools in combination with imaging and electrophysiological techniques to achieve the proposed objectives. Importantly, in vivo electrophysiology and two-photon imaging will be used to assess the functional relevance of NMDARs heterogeneity in single neuron computational strategies during sensory stimulation. I expect to reveal that NMDAR diversity plays a fundamental role in sensory information processing by tuning the relative recruitment of inhibitory and excitatory neurons during sensory stimuli. This work will provide an original and important data set demonstrating how NMDARs diversity provides cortical neurons with the possibility to compute complex sensory information.

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The information about "SENSONMDA" are provided by the European Opendata Portal: CORDIS opendata.

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