Opendata, web and dolomites

SensoNMDA SIGNED

Impact of NMDA receptor diversity in sensory information processing

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 SensoNMDA project word cloud

Explore the words cloud of the SensoNMDA project. It provides you a very rough idea of what is the project "SensoNMDA" about.

array    considerably    varies    computations    techniques    plasticity    recruitment    interneurons    densities    question    somatosensory    context    sensory    diversity    possibility    variability    modulators    combination    relationship    integration    brain    glutamatergic    excitatory    plays    biophysical    poorly    heterogeneity    cortex    consequence    highlighted    provides    primary    reveal    genetic    influenced    photon    thought    endogenous    computational    electrophysiological    s1    neuronal    mostly    vivo    data    electrophysiology    neuron    receptors    plan    demonstrating    optogenetic    cortical    adult    density    neurons    imaging    pharmacological    synapses    decompose    stimulation    synaptic    functional    tools    nmda    strategies    shapes    tuning    compute    relevance    stimuli    remarkable    connections    nmdars    single    relative    shaping    composition    nmdar    broad    capacities    inhibitory    dendritic    fundamental    original    subunit    simulations    model    signal    computation    despite    documented   

Project "SensoNMDA" data sheet

The following table provides information about the project.

Coordinator
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS 

Organization address
address: RUE MICHEL ANGE 3
city: PARIS
postcode: 75794
website: www.cnrs.fr

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country France [FR]
 Total cost 1˙200˙000 €
 EC max contribution 1˙200˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-STG
 Funding Scheme ERC-STG
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2021-11-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS FR (PARIS) coordinator 1˙200˙000.00

Map

 Project objective

Synaptic variability between neuronal connections is thought to contribute to brain’s remarkable information processing capacities. In the adult brain, the density as well as subunit composition of synaptic NMDA receptors (NMDARs) varies considerably between synapses and between neurons. Despite the well documented heterogeneity of NMDARs the functional relevance of such diversity is poorly known. In the past, the functional relevance of such NMDAR diversity has been mostly considered in the context of neuronal development and long-term synaptic plasticity. Model simulations have highlighted that dendritic computations are strongly influenced by synaptic NMDARs densities and biophysical properties. Here I propose to directly study the consequence of NMDAR diversity in shaping integration properties of single neurons in primary somatosensory cortex (S1). To achieve this I will decompose this broad question into three specific tasks. 1-Assessment of NMDAR heterogeneity in glutamatergic neurons and study how this variability shapes dendritic integration. 2-Study the impact of NMDARs in signal computation among cortical interneurons. 3-Investigate the functional relationship between endogenous NMDAR modulators and NMDAR diversity. I plan to use an array of genetic, optogenetic and pharmacological tools in combination with imaging and electrophysiological techniques to achieve the proposed objectives. Importantly, in vivo electrophysiology and two-photon imaging will be used to assess the functional relevance of NMDARs heterogeneity in single neuron computational strategies during sensory stimulation. I expect to reveal that NMDAR diversity plays a fundamental role in sensory information processing by tuning the relative recruitment of inhibitory and excitatory neurons during sensory stimuli. This work will provide an original and important data set demonstrating how NMDARs diversity provides cortical neurons with the possibility to compute complex sensory information.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "SENSONMDA" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "SENSONMDA" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

RECON (2019)

Reprogramming Conformation by Fluorination: Exploring New Areas of Chemical Space

Read More  

EvoLucin (2019)

400 Million Years of Symbiosis: Host-microbe interactions in marine lucinid clams from past to present

Read More  

HD-Neu-Screen (2020)

HD-MEA-based Neuronal Assays and Network Analysis for Phenotypic Drug Screenings

Read More