Opendata, web and dolomites

3DSTAR

Highly porous collagen scaffolds for building 3D vascular networks: structure and property relationships

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 3DSTAR project word cloud

Explore the words cloud of the 3DSTAR project. It provides you a very rough idea of what is the project "3DSTAR" about.

resistance    self    hydrated    investigation    conventional    drying    vitro    contribution    quantified    dried    time    excellence    modulus    interconnectivity    functional    suitable    blood    respectively    hierarchical    nutrient    static    maturation    photon    imaging    small    3d    removal    endothelial    property    gradient    lab    constant    vasculature    microscopy    perfusion    tomography    freeze    measured    hypoxia    native    characterisation    vascular    structures    customised    tests    shape    anisotropic    mechanical    fluid    mimicking    structure    architecture    repair    sizes    founding    pressure    diffusion    confocal    collagen    cells    ray    systematic    expertissues    ratios    single    engineered    organisation    dry    disciplinary    scaffolds    encompassing    pore    isotropic    biochemical    strain    network    waste    flow    function    surprisingly    inter    varied    permeability    view    culture    experimentation    original    germany    vs    assays    scaffold    cell    histology    size    mainz    vessels    co    variety    organization    young    significance   

Project "3DSTAR" data sheet

The following table provides information about the project.

Coordinator
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE 

Organization address
address: TRINITY LANE THE OLD SCHOOLS
city: CAMBRIDGE
postcode: CB2 1TN
website: www.cam.ac.uk

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country United Kingdom [UK]
 Project website https://www-memti.eng.cam.ac.uk/people/Sasha
 Total cost 195˙454 €
 EC max contribution 195˙454 € (100%)
 Programme 1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
 Code Call H2020-MSCA-IF-2015
 Funding Scheme MSCA-IF-EF-ST
 Starting year 2016
 Duration (year-month-day) from 2016-11-14   to  2018-11-13

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE UK (CAMBRIDGE) coordinator 195˙454.00

Map

 Project objective

This proposal concerns with the development of functional 3D hierarchical vasculature within engineered freeze-dried collagen scaffolds. The main objective is to investigate the contribution of scaffold’s pore architecture (size, shape and interconnectivity) and culture conditions, such as cell ratios in co-culture, perfusion vs. static culture and hypoxia, on the self-organisation of endothelial cells into vascular-like structures. A comprehensive 2-year, highly inter-disciplinary programme is planned encompassing processing, scaffold structure characterisation, structure-property investigation and systematic in vitro experimentation. The in vitro work will be carried out in collaboration with the REPAIR-lab in Mainz, Germany - a founding member of the European Commission Network of Excellence EXPERTISSUES. Freeze-drying process parameters will be varied to produce isotropic and anisotropic scaffolds, with pore sizes mimicking native small blood vessels. The pore architecture, in both dry and hydrated states, will be quantified via X-ray tomography and 2-photon confocal microscopy, respectively, using original methodologies. The Young’s modulus and resistance to fluid flow (permeability) of scaffolds will be measured as a function of pore architecture characteristics. A customised set-up allowing low strain measurements of Young’s modulus will be used to establish whether conventional mechanical testing is suitable. Fluid permeability will be measured by applying a constant pressure gradient. Rather surprisingly in view of permeability’s significance in nutrient diffusion and waste removal, there is only a single study on permeability. Vascular organization, maturation and functionality of optimised scaffolds will be studied as a function of pore architecture, using state-of-the-art microscopy, real-time imaging, perfusion tests, histology and a variety of biochemical assays.

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "3DSTAR" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "3DSTAR" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.3.2.)

TheaTheor (2018)

Theorizing the Production of 'Comedia Nueva': The Process of Play Configuration in Spanish Golden Age Theater

Read More  

InBPSOC (2020)

Increases biomass production and soil organic carbon stocks with innovative cropping systems under climate change

Read More  

ICL CHROM (2020)

DNA interstrand crosslink repair and chromatin remodelling

Read More