circRTrain SIGNED
circular RNA Biology Training Network: from biogenesis to biomarkers
Total Cost €
0EC-Contrib. €
0Partnership
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0circRTrain project word cloud
Explore the words cloud of the circRTrain project. It provides you a very rough idea of what is the project "circRTrain" about.
Project "circRTrain" data sheet
The following table provides information about the project.
| Coordinator |
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
Organization address contact info |
| Coordinator Country | Germany [DE] |
| Project website | https://circrtrain.eu/ |
| Total cost | 3˙870˙806 € |
| EC max contribution | 3˙870˙806 € (100%) |
| Programme |
1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers) |
| Code Call | H2020-MSCA-ITN-2016 |
| Funding Scheme | MSCA-ITN-ETN |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2020-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) | DE (BERLIN) | coordinator | 996˙865.00 |
| 2 | AARHUS UNIVERSITET | DK (AARHUS C) | participant | 731˙145.00 |
| 3 | UNIVERSITAIR MEDISCH CENTRUM UTRECHT | NL (UTRECHT) | participant | 510˙748.00 |
| 4 | JUSTUS-LIEBIG-UNIVERSITAET GIESSEN | DE (GIESSEN) | participant | 498˙432.00 |
| 5 | UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA | IT (ROMA) | participant | 401˙428.00 |
| 6 | FUNDACIO CENTRE DE REGULACIO GENOMICA | ES (BARCELONA) | participant | 362˙566.00 |
| 7 | QIAGEN AARHUS AS | DK (AARHUS) | participant | 290˙081.00 |
| 8 | THE HEBREW UNIVERSITY OF JERUSALEM | IL (JERUSALEM) | participant | 79˙536.00 |
| 9 | BIONEER A/S | DK (HOERSHOLM) | partner | 0.00 |
| 10 | EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH | DE (ST INGBERT) | partner | 0.00 |
| 11 | EXOSOMICS SIENA SPA | IT (SIENA) | partner | 0.00 |
| 12 | INTERNA TECHNOLOGIES BV | NL (NIJMEGEN) | partner | 0.00 |
Map
Project objective
CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particularly in neural tissues, circRNA expression is high, dynamic, and evolutionarily conserved. In aging animal brains the expression of certain circRNAs is strongly elevated, suggesting connections to age-related diseases. The study of circRNAs thus emerges as a novel topic with highest importance for the understanding of such diverse conditions as neurodegenerative diseases, aging, and cancer. Moreover, the highly stable expression and their presence in human blood and exosomes make circRNAs attractive biomarker candidates. The overall aims of circRTrain are to 1. Elucidate the biogenesis and function of circRNAs; 2. Define their role in diseases; 3. Exploit their potential as biomarkers and for medical applications; and 4. Combine cutting-edge technologies and disciplines. Understanding circRNAs and exploring their medical relevance requires to integrate various technologies (sequencing, single-molecule and whole-organism imaging, RNA knockdown/delivery, CRISPR/CAS9), disciplines (biochemistry, computational biology, genetics), model systems (worm, fly, mouse, human) and medical applications (biomarkers, new therapeutic strategies). CircRTrain will combine these diverse approaches and industrial technologies by training 15 early stage researchers (ESR) at two SMEs and seven academic partners, which are all leaders in their respective fields. Additionally, cooperation with four partner organizations, circRNA devoted conferences, winter- and summer schools will extend training for the ESRs, sustaining the critical number of young talented professionals in the field.
Deliverables
| Recruitment of 15 ESRs | Other | 2019-10-31 10:17:13 |
| Dissemination Toolkit | Documents, reports | 2019-10-31 10:17:13 |
| Project Website | Websites, patent fillings, videos etc. | 2019-10-31 10:17:13 |
Take a look to the deliverables list in detail: detailed list of circRTrain deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2018 |
Vera Zywitza, Aristotelis Misios, Lena Bunatyan, Thomas E. Willnow, Nikolaus Rajewsky Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis published pages: 2457-2469.e8, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.11.003 |
Cell Reports 25/9 | 2019-10-31 |
| 2018 |
Ines Lucia Patop, Sebastian Kadener circRNAs in Cancer published pages: 121-127, ISSN: 0959-437X, DOI: 10.1016/j.gde.2017.11.007 |
Current Opinion in Genetics & Development 48 | 2019-10-31 |
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The information about "CIRCRTRAIN" are provided by the European Opendata Portal: CORDIS opendata.