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circRTrain SIGNED

circular RNA Biology Training Network: from biogenesis to biomarkers

Total Cost €

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EC-Contrib. €

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Partnership

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Outcomes and
results

circRTrain project word cloud

Explore the words cloud of the circRTrain project. It provides you a very rough idea of what is the project "circRTrain" about.

biochemistry evolutionarily organism knockdown leaders biogenesis extend integrate circrna candidates stage neural discoveries attractive worm diverse function circrtrain attracted conserved edge elucidate publications medical biomarker closed cancer training critical covalently winter connections academic schools exosomes diseases young sequencing existence esr additionally rnas conferences cooperation esrs neurodegenerative technologies circrnas highest molecule professionals genetics stable age biology summer aging cas9 tissues seven human biomarkers animal dynamic of industrial smes model cells 15 class mouse suggesting combine ends revealed imaging certain crispr fly disciplines devoted relevance cutting talented single expression sustaining stranded rna therapeutic blood elevated brains respective computational circular strategies exploring emerges

Project "circRTrain" data sheet

The following table provides information about the project.

Coordinator	MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) Organization address address: ROBERT ROSSLE STRASSE 10 city: BERLIN postcode: 13125 website: www.mdc-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Germany [DE]
Project website	https://circrtrain.eu/
Total cost	3˙870˙806 €
EC max contribution	3˙870˙806 € (100%)
Programme	1. H2020-EU.1.3.1. (Fostering new skills by means of excellent initial training of researchers)
Code Call	H2020-MSCA-ITN-2016
Funding Scheme	MSCA-ITN-ETN
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2020-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC) Organization address address: ROBERT ROSSLE STRASSE 10 city: BERLIN postcode: 13125 website: www.mdc-berlin.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (BERLIN)	coordinator	996˙865.00
2	AARHUS UNIVERSITET AARHUS UNIVERSITET Organization address address: NORDRE RINGGADE 1 city: AARHUS C postcode: 8000 website: www.au.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS C)	participant	731˙145.00
3	UNIVERSITAIR MEDISCH CENTRUM UTRECHT UNIVERSITAIR MEDISCH CENTRUM UTRECHT Organization address address: HEIDELBERGLAAN 100 city: UTRECHT postcode: 3584 CX website: www.umcutrecht.nl contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (UTRECHT)	participant	510˙748.00
4	JUSTUS-LIEBIG-UNIVERSITAET GIESSEN JUSTUS-LIEBIG-UNIVERSITAET GIESSEN Organization address address: LUDWIGSTRASSE 23 city: GIESSEN postcode: 35390 website: www.uni-giessen.de contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (GIESSEN)	participant	498˙432.00
5	UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA UNIVERSITA DEGLI STUDI DI ROMA LA SAPIENZA Organization address address: Piazzale Aldo Moro 5 city: ROMA postcode: 185 website: www.uniroma1.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (ROMA)	participant	401˙428.00
6	FUNDACIO CENTRE DE REGULACIO GENOMICA FUNDACIO CENTRE DE REGULACIO GENOMICA Organization address address: CARRER DOCTOR AIGUADER 88 city: BARCELONA postcode: 8003 website: www.crg.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (BARCELONA)	participant	362˙566.00
7	QIAGEN AARHUS AS QIAGEN AARHUS AS Organization address address: SILKEBORGVEJ 2 city: AARHUS postcode: 8000 website: www.clcbio.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (AARHUS)	participant	290˙081.00
8	THE HEBREW UNIVERSITY OF JERUSALEM THE HEBREW UNIVERSITY OF JERUSALEM Organization address address: EDMOND J SAFRA CAMPUS GIVAT RAM city: JERUSALEM postcode: 91904 website: www.huji.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (JERUSALEM)	participant	79˙536.00
9	BIONEER A/S BIONEER A/S Organization address address: KOGLE ALLE 2 city: HOERSHOLM postcode: 2970 website: www.bioneer.dk contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DK (HOERSHOLM)	partner	0.00
10	EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH EURICE EUROPEAN RESEARCH AND PROJECT OFFICE GMBH Organization address address: HEINRICH-HERTZ-ALLEE 1 city: ST INGBERT postcode: 66386 website: www.eurice.eu contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	DE (ST INGBERT)	partner	0.00
11	EXOSOMICS SIENA SPA EXOSOMICS SIENA SPA Organization address address: VIA FIORENTINA 1 city: SIENA postcode: 53100 website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (SIENA)	partner	0.00
12	INTERNA TECHNOLOGIES BV INTERNA TECHNOLOGIES BV Organization address address: JONKERBOSPLEIN 52 city: NIJMEGEN postcode: 6534 AB website: www.interna-technologies.com contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	NL (NIJMEGEN)	partner	0.00

Map

Project objective

CircRTrain focuses on circular RNAs (circRNAs), a new large class of single-stranded RNAs with covalently closed ends. CircRNAs have only very recently attracted high general interest and become the focus of an increasing number of publications: recent discoveries through sequencing technology and computational analyses have revealed the widespread existence of circRNAs in animal cells. Particularly in neural tissues, circRNA expression is high, dynamic, and evolutionarily conserved. In aging animal brains the expression of certain circRNAs is strongly elevated, suggesting connections to age-related diseases. The study of circRNAs thus emerges as a novel topic with highest importance for the understanding of such diverse conditions as neurodegenerative diseases, aging, and cancer. Moreover, the highly stable expression and their presence in human blood and exosomes make circRNAs attractive biomarker candidates. The overall aims of circRTrain are to 1. Elucidate the biogenesis and function of circRNAs; 2. Define their role in diseases; 3. Exploit their potential as biomarkers and for medical applications; and 4. Combine cutting-edge technologies and disciplines. Understanding circRNAs and exploring their medical relevance requires to integrate various technologies (sequencing, single-molecule and whole-organism imaging, RNA knockdown/delivery, CRISPR/CAS9), disciplines (biochemistry, computational biology, genetics), model systems (worm, fly, mouse, human) and medical applications (biomarkers, new therapeutic strategies). CircRTrain will combine these diverse approaches and industrial technologies by training 15 early stage researchers (ESR) at two SMEs and seven academic partners, which are all leaders in their respective fields. Additionally, cooperation with four partner organizations, circRNA devoted conferences, winter- and summer schools will extend training for the ESRs, sustaining the critical number of young talented professionals in the field.

Deliverables

List of deliverables.
Recruitment of 15 ESRs	Other	2019-10-31 10:17:13
Dissemination Toolkit	Documents, reports	2019-10-31 10:17:13
Project Website	Websites, patent fillings, videos etc.	2019-10-31 10:17:13

Take a look to the deliverables list in detail: detailed list of circRTrain deliverables.

Publications

List of publications.
year	authors and title	journal	last update
2018	Vera Zywitza, Aristotelis Misios, Lena Bunatyan, Thomas E. Willnow, Nikolaus Rajewsky Single-Cell Transcriptomics Characterizes Cell Types in the Subventricular Zone and Uncovers Molecular Defects Impairing Adult Neurogenesis published pages: 2457-2469.e8, ISSN: 2211-1247, DOI: 10.1016/j.celrep.2018.11.003	Cell Reports 25/9	2019-10-31
2018	Ines Lucia Patop, Sebastian Kadener circRNAs in Cancer published pages: 121-127, ISSN: 0959-437X, DOI: 10.1016/j.gde.2017.11.007	Current Opinion in Genetics & Development 48	2019-10-31

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The information about "CIRCRTRAIN" are provided by the European Opendata Portal: CORDIS opendata.

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