Opendata, web and dolomites
H2020 projects about "cas9"
The page lists 153 projects related to the topic "cas9".
| # | |||
|---|---|---|---|
| 1 | IMSTREV | Immune modulation by lymph node stromal cell-derived extracellular vesicles | 2015 |
| 2 | EDPAS | Regulation of early embryo development and pluripotency through alternative splicing | 2015 |
| 3 | DecipherBILU | Understanding functional mechanisms leading to the BILU syndrome | 2015 |
| 4 | CARiPSCTcells | Generation of safe and efficient, off-the-shelf, chimeric antigen receptor (CAR)-engineered T cells for broad application | 2015 |
| 5 | HGSOC | A novel approach into modeling origin and development of ovarian cancer | 2015 |
| 6 | MELANOPARK | Investigating the LRRK2-melanin connection through phosphoproteomics of isogenic melanoma cells | 2015 |
| 7 | IntestineUb | The role of Ubiquitin System on the homeostatic control of stem cell maintenance and differentiation in crypt stem cells | 2016 |
| 8 | HepatoRiSK | A new tumor suppressor role for RSK2 in hepatocellular carcinoma | 2015 |
| 9 | DUALgRENP | A DUAL gRNA system for functional assessment of ENhancers in Pluripotency | 2016 |
| 10 | SPICE | Synthetic Lethal Phenotype Identification through Cancer Evolution Analysis | 2015 |
| 11 | UNEXPECTED | Uncovering targets for ex vivo expansion of hematopoietic stem cells to enhance cell therapies of blood disorders | 2015 |
| 12 | PlasmoSilencing | Exoribonuclease-mediated degradation of nascent RNA in Malaria Parasites: A Novel Mechanism in Virulence Gene Silencing | 2015 |
| 13 | CRISPAIR | Study of the interplay between CRISPR interference and DNA repair pathways towards the development of novel CRISPR tools | 2016 |
| 14 | INFANTLEUKEMIA | GENOMIC, CELLULAR AND DEVELOPMENTAL RECONSTRUCTION OFINFANT MLL-AF4+ ACUTE LYMPHOBLASTIC LEUKEMIA | 2016 |
| 15 | DROSADAPTATION | New approaches to long-standing questions: adaptation in Drosophila | 2016 |
| 16 | CFS modelling | Chromosomal Common Fragile Sites: Unravelling their biological functions and the basis of their instability | 2016 |
| 17 | PARPin | Regulation of (ADP-ribosyl)ation signalling in the DNA damage response: elucidating the function of a novel PARP1/ARTD1 interactor | 2016 |
| 18 | ReachingCompleteness | The Molecular Basis of Somatic Nuclear Reprogramming | 2016 |
| 19 | INTEGHER | Integration of herpesvirus into telomeres: From the mechanism of genome integration and mobilization to therapeutic intervention | 2016 |
| 20 | CasMETICS | Combining Single Molecule and Ensemble approaches To Investigate Cas9 Target Search | 2016 |
| 21 | KILLINGTYPHI | Identification of host-factors restricting Salmonella Typhi | 2016 |
| 22 | HairGen | Genetics of human hair form diversity | 2016 |
| 23 | CureCKDHeart | Targeting perivascular myofibroblast progenitors to treat cardiac fibrosis and heart failure in chronic kidney disease | 2016 |
| 24 | TransposonsReprogram | How retrotransposons remodel the genome during early development and reprogramming | 2016 |
| 25 | MITOBIOPATH | DISCOVERING NEW DISEASE PATHWAYS AFFECTING mtDNA METABOLISM | 2016 |
| 26 | SynthHotSpot | Synthesizing Meiotic Crossover Hotspots in Arabidopsis | 2016 |
| 27 | REPROHEAT | Increasing reproductive success in crops under high ambient temperature | 2017 |
| 28 | DMD2CURE | Correction of duplications in the DMD gene by a CRISPR/Cas9 approach | 2017 |
| 29 | UNICODE | Evolution and Impact of Heterochromatin on a Young Drosophila Y chromosome | 2016 |
| 30 | ToxoPersist | Molecular Basis of Toxoplasma gondii Encystation and Persistence | 2016 |
| 31 | HRMECH | Nucleases in homologous recombination: from basic principles to genome editing | 2016 |
| 32 | LYSOSOMICS | Functional Genomics of the Lysosome | 2016 |
| 33 | HOXA9 degradome | Deciphering the machinery involved in stability of the transcription factor HOXA9. | 2016 |
| 34 | BRCANCER | A novel approach for modeling development of breast cancer | 2016 |
| 35 | circRTrain | circular RNA Biology Training Network: from biogenesis to biomarkers | 2017 |
| 36 | DanioPattern | Development and Evolution of Colour Patterns in Danio species | 2016 |
| 37 | MacAGE | Macrophage aging and rejuvenation | 2017 |
| 38 | GENE FOR CURE | Expanding and extending gene therapy of monogenic diseases of the haematopoietic system | 2016 |
| 39 | 3D-REPAIR | Spatial organization of DNA repair within the nucleus | 2017 |
| 40 | 3D_Tryps | The role of three-dimensional genome architecture in antigenic variation | 2017 |
| 41 | CRISP-4-CROPS | CRISPR/Cas9 technology implementation for improved resistance to Abiotic Stress in cereals | 2017 |
| 42 | Cytokineproteomics | Investigating inflammatory signaling by combining phospho- and ubiquitin proteomics with CRISPR/Cas9 technology | 2017 |
| 43 | Repro_organoid | Direct reprogramming of human astrocytes into functional neurons in cerebral organoids derived from genome edited hiPSCs | 2017 |
| 44 | REACT | Uncovering the role of cis genetic elements in antigenic variation of Plasmodium falciparum using the CRISPR-Cas9 genome editing technology | 2018 |
| 45 | DREMATURE | DNA repair mechanisms and therapy resistance of BRCA2-deficient cancers | 2018 |
| 46 | GREEN-SPECIALISTS | Specialised plant cell types via developmentally-controlled gene knockouts: a key step towards fully customised plants | 2018 |
| 47 | StressEBOV | Ebola virus manipulation of the cellular stress responses | 2017 |
| 48 | Anti-CRISPR | Uncovering viral sabotage of host CRISPR-Cas immune systems | 2018 |
| 49 | CHI-ZEF | Cdon-Hh Interaction: functional in vivo analysis in zebrafish | 2017 |
| 50 | CD4CRISPR | A quorum sensing mechanism regulating CD4 T cell proliferation | 2017 |
| 51 | Pharynx2016 | Evolution and development of pharyngeal pouches and pre-oral gut in basal fishes | 2017 |
| 52 | HOST-SELECT | Functional Analysis of Host Genetic Variants: Biomarker Selection Towards Improving Female Subfertility Diagnosis and Treatment | 2017 |
| 53 | HERPES | Herpesvirus Effectors of RNA synthesis, Processing, Export and Stability | 2017 |
| 54 | GenEdiDS | Rescuing Cognitive Deficits in Neurodevelopmental Disorders by Gene Editing in Brain Development: the Case of Down Syndrome | 2017 |
| 55 | CORFEDITING | Gene Editing as Therapeutic Strategy for C9ORF72 Linked ALS/FTD | 2017 |
| 56 | Secret Surface | The cell surface tetraspanin web drives tumour development and alters metabolic signalling | 2017 |
| 57 | PlasmaCellControl | Transcriptional control of plasma cell development and function | 2018 |
| 58 | CRISBREED | Multidimensional CRISPR/Cas mediated engineering of plant breeding | 2017 |
| 59 | PD UpReg | Gene knock-up via 3’UTR targeting to treat Parkinson’s disease | 2017 |
| 60 | MALEPREG | Male pregnancy – Unravelling the coevolution of parental investment and immune defence | 2018 |
| 61 | SC-EpiCode | Decoding the Epigenomic Regulatory Code by the Use of Single Cell Technologies | 2017 |
| 62 | deFIBER | Dissecting the cellular and molecular dynamics of bone marrow fibrosis for improved diagnostics and treatment | 2018 |
| 63 | CELLNAIVETY | Deciphering the Molecular Foundations and Functional Competence of Alternative Human Naïve Pluripotent Stem Cells | 2017 |
| 64 | CRISS | CRISPR Gene Correction for Severe Combined Immunodeficiency Caused by Mutations in Recombination-activating gene 1 and 2 (RAG1 and RAG2) | 2017 |
| 65 | HD-DittoGraph | HD-DittoGraph: a digital human Embryonic Stem Cell platform for Huntington's repeats | 2018 |
| 66 | DIAMONDCOR | A molecular approach to treat diabetes mellitus onset dependent coronaropathy | 2018 |
| 67 | ORGANOMICS | Reconstructing human cortex development and malformation with single-cell transcriptomics | 2018 |
| 68 | ANTIViR | Molecular mechanisms of interferon-induced antiviral restriction and signalling | 2017 |
| 69 | MASTFAST | Rapid production of HUMAN MAST CELLS | 2017 |
| 70 | ImmunoFit | Harnessing tumor metabolism to overcome immunosupression | 2018 |
| 71 | SmallDrugRheuma | Discovery of Immune Therapeutic Targets and Immunomodulators for the Development of Novel Therapies in Rheumatoid Arthritis. | 2018 |
| 72 | Alpha-Synuclein | Blocking the prion-like disease propagation in Parkinson’s disease and related disorders – model development and identification of cell-autonomous and cell non-autonomous factors. | 2019 |
| 73 | MeloCRISP | Implementation of CRISPR/Cas9 technology in melon to edit fruit ripening and CMV resistant genes | 2018 |
| 74 | INTERGLU | Dissecting mGlu5 receptor internalization pathways using genetic and pharmacological tools | 2018 |
| 75 | CRISPR-GQ | Identifying the Capabilities and Limitations of CRISPR in Targeting G-quadruplex Forming Sequences: From Target Recognition to Gene Expression Regulation | 2018 |
| 76 | DNAProteinCrossRep | Identification of DNA-Protein-Crosslink Repair Factors | 2018 |
| 77 | EScORIAL | Emerging Simplex ORigins In ALS | 2018 |
| 78 | Sialoglycan Array | Generation of a Cell-Based Sialoglycan Array to Decipher Biological Interactions and Functions of the Human Sialome | 2018 |
| 79 | METLINK | METLINK: Identification of links between cancer cell growth and metabolism genes. | 2018 |
| 80 | TFs-HSCs | The identification of the Combinatorial Transcription Factor network exerting different roles in Hematopoietic Stem Cells. | 2019 |
| 81 | VIAR | Virus-induced autophagy restriction | 2018 |
| 82 | NACHO | Nicotine actions on beta cell function in health and disease | 2018 |
| 83 | PathAutoBIO | Uncovering the pathway of DNA-induced autophagy and its biological functions in viral central nervous system infection | 2018 |
| 84 | NEMoCuRe | Role of S-Nitrosylation of epigenetic modifiers in vascular regeneration | 2018 |
| 85 | UNNAMEd-2 | Unraveling the conceptional novel ADAM17 regulation by PP2A in metastasis formation. | 2019 |
| 86 | transLEISHion | A targeted knockout screen for identification of Leishmania membrane transporters required for infection of macrophages | 2018 |
| 87 | MemCHAPS | Intramembrane chaperones : their role in folding membrane proteins | 2019 |
| 88 | ItohRibo | Structural study on mitochondrial ribosome assembly in human cells | 2018 |
| 89 | MiniBRAIN | Investigating the pathogenic mechanisms underlying TUBB2B-related brain malformations using induced pluripotent stem cells and cerebral organoids. | 2019 |
| 90 | TRANSREG | Dissecting the role of Translational Regulation in Tumorigenesis | 2018 |
| 91 | EPICut | Molecular mechanisms, evolutionary impacts and applications of prokaryotic epigenetic-targeted immune systems | 2018 |
| 92 | HELPHERGEN | THE GENETIC BASIS OF MATING BEHAVIOR: PHEROMONE COMMUNICATION IN NOCTUID MOTHS | 2018 |
| 93 | HOPE | Host Protective Engineering of Cancer Immunity by Targeting the Intracellular Immune Checkpoint NR2F6 | 2018 |
| 94 | RiboLife | Resurrecting LUCA - Engineering of RNA-encoded Cellular Life Using Dual Evolution and Intergenomic Transplantation | 2019 |
| 95 | COEVOPRO | Drivers and consequences of coevolution in protective symbiosis | 2019 |
| 96 | StarT | European Training Network to Diagnose, Understand and Treat Stargardt Disease, a Frequent Inherited Blinding Disorder | 2018 |
| 97 | RESHAPE | Reshaping undesired Inflammation in challenged Tissue Homeostasis by Next-Generation regulatory T cell (Treg) Approaches – from Advanced Technology Developments to First-in-Human Trials | 2019 |
| 98 | REMIND | Targeting pathological synaptic pruning by microglia in neurodegeneration | 2019 |
| 99 | PedSarc | Targeting genetic and epigenetic mechanisms in pediatric sarcomas. | 2019 |
| 100 | VOLARE | Scentsitive nature: Green leaf volatile perception in plants and insects | 2019 |
| 101 | MIGHTY_RNA | Repurposing small RNA from ciliates for genome editing: single-molecule study | 2019 |
| 102 | EpiTune | Epigenetic fine-tuning of T cells for improved adoptive cell therapy | 2019 |
| 103 | INFLAME | Deciphering the host and microbial grounds that license inflammasome-mediated execution | 2018 |
| 104 | EPIORGABOLISM | Diabetic nephropathy modelling in hESC-derived 3D kidney organoids | 2019 |
| 105 | Neurovulnerability | Molecular mechanisms underlying selective neuronal death in motor neuron diseases | 2019 |
| 106 | EPICROP | Dissecting epistasis for enhanced crop productivity | 2019 |
| 107 | CORKtheCAMBIA | Thickening of plant organs by nested stem cells | 2019 |
| 108 | IndiGene | Genetics of Individuality | 2019 |
| 109 | CRISPR2.0 | Microbial genome defence pathways: from molecular mechanisms to next-generation molecular tools | 2019 |
| 110 | TRANSLIGHT | Light-dependent composition of transcriptional complexes in plants | 2019 |
| 111 | R-FunSel | In vivo functional screening via CRISPR-Cas9 to systematically identify cardiomyocyte receptors as targets for the innovative therapies for myocardial infarction and heart failure | 2019 |
| 112 | REAP | Repair of DNA lesions induced by platinum drugs | 2019 |
| 113 | FrATGaria | Identification of the role of autophagy during fruit ripening and stress resistance in Strawberry: Autophagy manipulation as a way to improve Strawberry fitness | 2019 |
| 114 | DECODE | Decoding Context-Dependent Genetic Networks in vivo | 2019 |
| 115 | POPMET | Large-scale identification of secondary metabolites, metabolic pathways and their genes in the model tree poplar | 2019 |
| 116 | MsgRNA | Modification of single guide (sg) RNA in CRISPR-Cas9 gene editing Tool | 2019 |
| 117 | AR-DDR | Co-targeting androgen receptor signalling and DNA damage repair for precision therapy in advanced prostate cancer | 2019 |
| 118 | MetAeAvIm | The Role of the Metabolism in Mosquito Immunity against Dengue virus in Aedes aegypti | 2019 |
| 119 | InvADeRS | Investigating the Activity of transposon Derived Regulatory Sequences in the placenta | 2019 |
| 120 | CRISPR-KissCas9 | Challenging the KNDy Hypothesis Using CRISPR-Cas9 Genome Editing: Evaluation of the Role of Neurokinin B and Dynorphin in Kiss1 neurons in the Control of Fertility | 2020 |
| 121 | iMIND | iPS-derived MIcroglia and Neuroinflammation in Dementia | 2020 |
| 122 | GenDels | Development of a new CRISPR-Cas3-based tool for large genomic deletions | 2019 |
| 123 | MalusEdit | Malus genome editing via CRISPR/Cas9 to develop sustainable pest free apples | 2019 |
| 124 | BREEDIT | A NOVEL BREEDING STRATEGY USING MULTIPLEX GENOME EDITING IN MAIZE | 2019 |
| 125 | ImmUne | Towards identification of the unifying principles of vertebrate adaptive immunity | 2019 |
| 126 | RegulatioNFkB | Deciphering transcriptional regulation of NF-kB target genes using integrative omics approaches | 2019 |
| 127 | MitoQuant | Development of Deep-UV Quantitative Microscopy for the Study of Mitochondrial Dysfunction | 2019 |
| 128 | ReproXimera | Modelling in vivo lineage reprogramming of human astrocytes into induced neurons in the adult mouse brain | 2020 |
| 129 | SUPERTEFF | A new paradigm in boosting orphan crops to super grains: Linking metabolomics and gene editing to improve Teff for global food security and sustainable agriculture | 2020 |
| 130 | InScope | Integrated analysis of regulatory networks modulating seed coat permeability in natural accessions | 2019 |
| 131 | EVOMORPHYS | Identifying how Evolution exploits physical properties of tissues to generate the complexity and diversity of Life | 2019 |
| 132 | GHSO | Generation of human steroid-producing organoids: a new approach to treat adrenal insufficiency | 2019 |
| 133 | DNA-DOCK | Precision Docking of Very Large DNA Cargos in Mammalian Genomes | 2019 |
| 134 | Genetic Vaccine | Study the therapeutic and preventive potential of targeting oncogenic mutations with CRISPR-Cas9 technology | 2019 |
| 135 | EpiSeq | Single molecule sequencing and biophysical properties of oxidized genomic DNA using magnetic tweezers. | 2019 |
| 136 | CLOCK | Characterization of the circadian chromatin landscape using a novel CRISPR/Cas9-guided proximity-labelling technique | 2020 |
| 137 | INTERGLP1 | Dissecting GLP-1 receptor internalization pathways using genetic and pharmacological tools | 2020 |
| 138 | TRYPTISSUE | Characterising Trypanosoma tissue tropism: new perspectives for variant surface glycoproteins | 2019 |
| 139 | I-GENE | In-vivo Gene Editing by NanotransducErs | 2019 |
| 140 | CELLPHASE_AD | Genetics to understand cellular components of Alzheimer Disease pathogenesis | 2019 |
| 141 | Bac2MUC | Bacteria-mucin interactions – Shaping intestinal epithelial responses in health and disease | 2020 |
| 142 | PARPinhibit | A systems biology approach to tackle PARP-inhibitors resistance and identify novel therapeutic targets to overcome it | 2020 |
| 143 | OBSERVE | Overcoming cellular barriers to therapeutic RNA delivery using extracellular vesicles | 2020 |
| 144 | CCedit | Coiled-coil mediated exonuclease tethering technology for the enhancement of CRISPR gene editing | 2020 |
| 145 | NATURE-ETN | Nucleic Acids for Future Gene Editing, Immunotherapy and Epigenetic Sequence Modification | 2020 |
| 146 | HumanPlacenta | Human Placental Development and the Uterine Microenvironment | 2020 |
| 147 | RARE MAPS | Dynamic proteomic maps of stem cell-derived neurons as a mechanistic discovery pipeline for rare neurological disease | 2020 |
| 148 | LINKER | Elucidating transcriptional rewiring on hematological malignancies via computational methods | 2020 |
| 149 | xenCAKUT | CRISPR/Cas9 based kidney disease modeling to elucidate novel genetic drivers and therapeutic targets in X. tropicalis | 2020 |
| 150 | NANOCRISPR | NANODELIVERY OF SPECIFIC GENOME ENGINEERING TOOLS AS A NOVEL THERAPEUTIC APPROACH FOR AGGRESSIVE PROSTATE CANCERS | 2021 |
| 151 | ICaRMuSs | Intragranullar calcium regulation of mucin secretion and sorting. | 2020 |
| 152 | PATHOCODE | Molecular pathology of anti-viral T cell responses in the central nervous system | 2020 |
| 153 | ADGENTHE-CDA | Advances in the Diagnosis and Gene Therapy of Congenital dyserythropoietic Anemia | 2020 |