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ACCENT SIGNED

Unravelling the architecture and the cartography of the human centriole

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

ACCENT project word cloud

Explore the words cloud of the ACCENT project. It provides you a very rough idea of what is the project "ACCENT" about.

combine core nanometric unravel centrosomes missing macromolecular centriole evolutionary cell encompassing deep electron understand question structural fragmented central underlying structure undertaken spatial critical function centrioles techniques details architectural eukaryotes mechanisms microscopy architecture proper pathologies biological molecular assays basis rooted ciliopathies organization groundbreaking lacking basic mapping cryo cancer proteomics emphasizes cilia proteins multidisciplinary composition innovative centriolar defects signaling resolution building region vitro responsible conserved relevance facts limited tomography elucidating tackle division undoubtedly exquisite ranging flagella health biogenesis resolving cartography principles view human

Project "ACCENT" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	1˙498˙965 €
EC max contribution	1˙498˙965 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-STG
Funding Scheme	ERC-STG
Starting year	2017
Duration (year-month-day)	from 2017-01-01 to 2021-12-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITE DE GENEVE UNIVERSITE DE GENEVE Organization address address: RUE DU GENERAL DUFOUR 24 city: GENEVE postcode: 1211 website: www.unige.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (GENEVE)	coordinator	1˙498˙965.00

Map

Project objective

The centriole is the largest evolutionary conserved macromolecular structure responsible for building centrosomes and cilia or flagella in many eukaryotes. Centrioles are critical for the proper execution of important biological processes ranging from cell division to cell signaling. Moreover, centriolar defects have been associated to several human pathologies including ciliopathies and cancer. This state of facts emphasizes the importance of understanding centriole biogenesis. The study of centriole formation is a deep-rooted question, however our current knowledge on its molecular organization at high resolution remains fragmented and limited. In particular, exquisite details of the overall molecular architecture of the human centriole and in particular of its central core region are lacking to understand the basis of centriole organization and function. Resolving this important question represents a challenge that needs to be undertaken and will undoubtedly lead to groundbreaking advances. Another important question to tackle next is to develop innovative methods to enable the nanometric molecular mapping of centriolar proteins within distinct architectural elements of the centriole. This missing information will be key to unravel the molecular mechanisms behind centriolar organization. This research proposal aims at building a cartography of the human centriole by elucidating its molecular composition and architecture. To this end, we will combine the use of innovative and multidisciplinary techniques encompassing spatial proteomics, cryo-electron tomography, state-of-the-art microscopy and in vitro assays and to achieve a comprehensive molecular and structural view of the human centriole. All together, we expect that these advances will help understand basic principles underlying centriole and cilia formation as well as might have further relevance for human health.

Publications

List of publications.
year	authors and title	journal	last update
2019	Davide Gambarotto, Fabian U. Zwettler, Maeva Le Guennec, Marketa Schmidt-Cernohorska, Denis Fortun, Susanne Borgers, JÃ¶rn Heine, Jan-Gero Schloetel, Matthias Reuss, Michael Unser, Edward S. Boyden, Markus Sauer, Virginie Hamel, Paul Guichard Imaging cellular ultrastructures using expansion microscopy (U-ExM) published pages: 71-74, ISSN: 1548-7091, DOI: 10.1038/s41592-018-0238-1	Nature Methods 16/1	2019-09-04
2019	Marketa Schmidt-Cernohorska, Ilia Zhernov, Emmanuelle Steib, Maeva Le Guennec, Rim Achek, Susanne Borgers, Davide Demurtas, Liliane Mouawad, Zdenek Lansky, Virginie Hamel, Paul Guichard Flagellar microtubule doublet assembly in vitro reveals a regulatory role of tubulin C-terminal tails published pages: 285-288, ISSN: 0036-8075, DOI:	Science 363/6424	2019-09-04
2018	Christian Sieben, Kyle M Douglass, Paul Guichard, Suliana Manley Super-resolution microscopy to decipher multi-molecular assemblies published pages: 169-176, ISSN: 0959-440X, DOI: 10.1016/j.sbi.2018.03.017	Current Opinion in Structural Biology 49	2019-06-13

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The information about "ACCENT" are provided by the European Opendata Portal: CORDIS opendata.