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Neurofibres SIGNED
Biofunctionalised Electroconducting Microfibres for the Treatment of Spinal Cord Injury
Total Cost €
0EC-Contrib. €
0Partnership
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0Neurofibres project word cloud
Explore the words cloud of the Neurofibres project. It provides you a very rough idea of what is the project "Neurofibres" about.
central
hold
mf
immunological
inflicts
conductivity
connective
electro
stability
bio
biomaterials
meet
ultrasensitive
microcables
glial
rodents
nervous
ensuing
neural
negligible
implantation
migration
efforts
rodent
motor
electrical
microsystems
perform
neuroscientists
specialised
sensory
join
electroconducting
complementary
treatment
mechanical
implanted
company
spinal
function
repairing
neurofibres
models
electrostimulation
dual
guided
cns
chemical
damaged
recording
probe
affibodies
axonal
scaffolds
promise
strength
neuroregenerative
medical
electronic
regeneration
engineering
serve
microfibre
microconnectors
interdisciplinary
electroactive
biofunctionalisation
safe
stimulation
cord
device
add
mfs
engineered
additional
activation
inflammation
compromise
functionalisation
responsive
electronics
sci
biologically
neuronal
fibrosis
tissue
injury
interconnection
physics
swine
cell
implantable
breakthrough
miniaturisation
investigation
assembling
fabrication
specialists
microfibres
insult
circuit
protein
Project "Neurofibres" data sheet
The following table provides information about the project.
| Coordinator |
SERVICIO DE SALUD DE CASTILLA LA MANCHA
Organization address contact info |
| Coordinator Country | Spain [ES] |
| Project website | http://www.neurofibres.eu |
| Total cost | 5˙888˙491 € |
| EC max contribution | 5˙094˙120 € (87%) |
| Programme |
1. H2020-EU.1.2.2. (FET Proactive) |
| Code Call | FETPROACT-2016 |
| Funding Scheme | RIA |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-01-01 to 2020-12-31 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | SERVICIO DE SALUD DE CASTILLA LA MANCHA | ES (TOLEDO) | coordinator | 751˙835.00 |
| 2 | AXON CABLE | FR (MONTMIRAIL) | participant | 910˙000.00 |
| 3 | THE CHANCELLOR MASTERS AND SCHOLARSOF THE UNIVERSITY OF CAMBRIDGE | UK (CAMBRIDGE) | participant | 708˙090.00 |
| 4 | KUNGLIGA TEKNISKA HOEGSKOLAN | SE (STOCKHOLM) | participant | 692˙500.00 |
| 5 | UNIVERSITE D'AIX MARSEILLE | FR (Marseille) | participant | 681˙875.00 |
| 6 | UNIVERSITAT DES SAARLANDES | DE (SAARBRUCKEN) | participant | 680˙000.00 |
| 7 | UNIVERSITA DEGLI STUDI DI TRENTO | IT (TRENTO) | participant | 669˙820.00 |
Map
Project objective
Bio-electronic microsystems hold promise for repairing the damaged central nervous system (CNS). However, this potential has not been developed because their implantation inflicts additional neural injury, and ensuing inflammation and fibrosis compromise device functionality. In Neurofibres we want to achieve a breakthrough in “Neuroregenerative Bio-electronics”, developing dual-function devices that will serve as electroactive scaffolds for CNS regeneration and neural circuit activation. We engineered electroconducting microfibres (MFs) that add negligible tissue insult while promoting guided cell migration and axonal regeneration in rodents with spinal cord injury (SCI). The MFs also meet the challenge of probe miniaturisation and biofunctionalisation for ultrasensitive recording and stimulation of neural activity. An interdisciplinary consortium composed of neuroscientists, medical specialists, researchers in biomaterials, protein engineering, physics, and electrical and mechanical engineering, together with a company specialised in fabrication of microcables and microconnectors, will join efforts to design, develop, and test the MFs and complementary technology (microfibre functionalisation, assembling, and electronic interconnection), in order to produce a biologically safe and effective bio-electronic system for the treatment of SCI. This goal will be achieved through five specific objectives: 1) To improve the electrical conductivity, strength, and chemical stability of the microfibres. 2) To develop electro-responsive engineered affibodies for microfibre functionalisation. 3) To develop the technology for MF interconnection and assembling into implantable systems. 4) To perform comprehensive investigation of the immunological, glial, neuronal, and connective tissue responses to the implanted MFs and applied electrostimulation in rodent and swine SCI models. 5) To investigate the motor and sensory effects of microfibre implantation and electrostimulation.
Deliverables
| Generation of new affibodies binding bFGF or N-Cadherin | Documents, reports | 2020-01-23 08:43:01 |
| Analytical and numerical models for the mechanical behaviour of the implanted MFs. | Documents, reports | 2020-01-23 08:43:01 |
| Website and logo for NEUROFIBRES | Websites, patent fillings, videos etc. | 2020-01-23 08:43:01 |
| Data management plan | Open Research Data Pilot | 2020-01-23 08:43:01 |
Take a look to the deliverables list in detail: detailed list of Neurofibres deliverables.
Publications
| year | authors and title | journal | last update |
|---|---|---|---|
| 2017 |
Matteo Moncalero, Stefano Signetti, Barbara Mazzanti, Pietro Bruzzi, Nicola M. Pugno, Martino Colonna Effect of material elastic properties and surface roughness on grip performances of ski boot soles under wet and icy conditions published pages: 62-70, ISSN: 0169-8141, DOI: 10.1016/j.ergon.2017.04.004 |
International Journal of Industrial Ergonomics 61 | 2020-01-23 |
| 2017 |
Omar Tricinci, Tercio Terencio, Nicola Pugno, Francesco Greco, Barbara Mazzolai, Virgilio Mattoli Air Trapping Mechanism in Artificial Salvinia-Like Micro-Hairs Fabricated via Direct Laser Lithography published pages: 366, ISSN: 2072-666X, DOI: 10.3390/mi8120366 |
Micromachines 8/12 | 2020-01-23 |
| 2017 |
Zhang, Yi; Falco, P.; Wang, Y.; Barbieri, E.; Paris, O.; Terrill, N. J.; Falkenberg, G.; Pugno, N. M.; Gupta, H. S. Towards in situ determination of 3D strain and reorientation in the interpenetrating nanofibre networks of cuticle published pages: 11249 - 11260, ISSN: 2040-3372, DOI: 10.3204/PUBDB-2017-11841 |
Nanoscale 9 | 2020-01-23 |
| 2017 |
Martina Azzolini, Tommaso Morresi, Giovanni Garberoglio, Lucia Calliari, Nicola M. Pugno, Simone Taioli, Maurizio Dapor Monte Carlo simulations of measured electron energy-loss spectra of diamond and graphite: Role of dielectric-response models published pages: 299-309, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2017.03.041 |
Carbon 118 | 2020-01-23 |
| 2017 |
Panagiotis G. Karagiannidis, Stephen A. Hodge, Lucia Lombardi, Flavia Tomarchio, Nicolas Decorde, Silvia Milana, Ilya Goykhman, Yang Su, Steven V. Mesite, Duncan N. Johnstone, Rowan K. Leary, Paul A. Midgley, Nicola M. Pugno, Felice Torrisi, Andrea C. Ferrari Microfluidization of Graphite and Formulation of Graphene-Based Conductive Inks published pages: 2742-2755, ISSN: 1936-0851, DOI: 10.1021/acsnano.6b07735 |
ACS Nano 11/3 | 2020-01-23 |
| 2017 |
Emiliano Lepore, Federico Bosia, Francesco Bonaccorso, Matteo Bruna, Simone Taioli, Giovanni Garberoglio, Andrea C Ferrari, Nicola Maria Pugno Spider silk reinforced by graphene or carbon nanotubes published pages: 31013, ISSN: 2053-1583, DOI: 10.1088/2053-1583/aa7cd3 |
2D Materials 4/3 | 2020-01-23 |
| 2018 |
Gianluca Costagliola, Federico Bosia, Nicola M. Pugno A 2-D model for friction of complex anisotropic surfaces published pages: 50-65, ISSN: 0022-5096, DOI: 10.1016/j.jmps.2017.11.015 |
Journal of the Mechanics and Physics of Solids 112 | 2020-01-23 |
| 2017 |
F. Dal Corso, D. Misseroni, N. M. Pugno, A. B. Movchan, N. V. Movchan, D. Bigoni Serpentine locomotion through elastic energy release published pages: 20170055, ISSN: 1742-5689, DOI: 10.1098/rsif.2017.0055 |
Journal of The Royal Society Interface 14/130 | 2020-01-23 |
| 2017 |
Massimo Totaro, Nicola Maria Pugno, Barbara Mazzolai, Lucia Beccai Micromechanical Analysis of Soft Tactile Sensors published pages: 3, ISSN: 2296-8016, DOI: 10.3389/fmats.2017.00003 |
Frontiers in Materials 4 | 2020-01-23 |
| 2017 |
R.A. Bizao, T. Botari, E. Perim, Nicola M. Pugno, D.S. Galvao Mechanical properties and fracture patterns of graphene (graphitic) nanowiggles published pages: 431-437, ISSN: 0008-6223, DOI: 10.1016/j.carbon.2017.04.018 |
Carbon 119 | 2020-01-23 |
| 2017 |
Gianluca Costagliola, Federico Bosia, Nicola M. Pugno Tuning friction with composite hierarchical surfaces published pages: 261-267, ISSN: 0301-679X, DOI: 10.1016/j.triboint.2017.05.012 |
Tribology International 115 | 2020-01-23 |
| 2017 |
Prospero J. Taroni, Giovanni Santagiuliana, Kening Wan, Philip Calado, Manting Qiu, Han Zhang, Nicola M. Pugno, Matteo Palma, Natalie Stingelin-Stutzman, Martin Heeney, Oliver Fenwick, Mark Baxendale, Emiliano Bilotti Toward Stretchable Self-Powered Sensors Based on the Thermoelectric Response of PEDOT:PSS/Polyurethane Blends published pages: 1704285, ISSN: 1616-301X, DOI: 10.1002/adfm.201704285 |
Advanced Functional Materials | 2020-01-23 |
| 2017 |
M. Miniaci, A. S. Gliozzi, B. Morvan, A. Krushynska, F. Bosia, M. Scalerandi, N. M. Pugno Proof of Concept for an Ultrasensitive Technique to Detect and Localize Sources of Elastic Nonlinearity Using Phononic Crystals published pages: 214301, ISSN: 0031-9007, DOI: 10.1103/PhysRevLett.118.214301 |
Physical Review Letters 118/21 | 2020-01-23 |
| 2017 |
Gianluca Costagliola, Federico Bosia, Nicola M. Pugno Tuning friction with composite hierarchical surfaces published pages: 261-267, ISSN: 0301-679X, DOI: 10.1016/j.triboint.2017.05.012 |
Tribology International 115 | 2020-01-23 |
| 2018 |
Gianluca Costagliola, Federico Bosia, Nicola M. Pugno A 2-D model for friction of complex anisotropic surfaces published pages: 50-65, ISSN: 0022-5096, DOI: 10.1016/j.jmps.2017.11.015 |
Journal of the Mechanics and Physics of Solids 112 | 2020-01-23 |
| 2017 |
Silvia Taccola, Virginia Pensabene, Toshinori Fujie, Shinji Takeoka, Nicola M. Pugno, Virgilio Mattoli On the injectability of free-standing magnetic nanofilms published pages: , ISSN: 1387-2176, DOI: 10.1007/s10544-017-0192-1 |
Biomedical Microdevices 19/3 | 2020-01-23 |
| 2017 |
Raimonds Meija, Stefano Signetti, Arnim Schuchardt, Kerstin Meurisch, Daria Smazna, Matthias Mecklenburg, Karl Schulte, Donats Erts, Oleg Lupan, Bodo Fiedler, Yogendra Kumar Mishra, Rainer Adelung, Nicola M. Pugno Nanomechanics of individual aerographite tetrapods published pages: 14982, ISSN: 2041-1723, DOI: 10.1038/ncomms14982 |
Nature Communications 8 | 2020-01-23 |
| 2017 |
F. Dal Corso, D. Misseroni, N. M. Pugno, A. B. Movchan, N. V. Movchan, D. Bigoni Serpentine locomotion through elastic energy release published pages: 20170055, ISSN: 1742-5689, DOI: 10.1098/rsif.2017.0055 |
Journal of The Royal Society Interface 14/130 | 2020-01-23 |
| 2017 |
Stefano Signetti, Simone Taioli, Nicola M. Pugno 2D Material Armors Showing Superior Impact Strength of Few Layers published pages: 40820-40830, ISSN: 1944-8244, DOI: 10.1021/acsami.7b12030 |
ACS Applied Materials & Interfaces 9/46 | 2020-01-23 |
| 2017 |
A. Taraghi Osguei, M.T. Ahmadian, M. Asghari, N.M. Pugno Free vibration analysis of cylindrical panels with spiral cross section published pages: 376-386, ISSN: 0020-7403, DOI: 10.1016/j.ijmecsci.2017.07.044 |
International Journal of Mechanical Sciences 133 | 2020-01-23 |
| 2017 |
Giorgia Nardone, Jorge Oliver-De La Cruz, Jan Vrbsky, Cecilia Martini, Jan Pribyl, Petr Skládal, Martin Pešl, Guido Caluori, Stefania Pagliari, Fabiana Martino, Zuzana Maceckova, Marian Hajduch, Andres Sanz-Garcia, Nicola Maria Pugno, Gorazd Bernard Stokin, Giancarlo Forte YAP regulates cell mechanics by controlling focal adhesion assembly published pages: 15321, ISSN: 2041-1723, DOI: 10.1038/ncomms15321 |
Nature Communications 8 | 2020-01-23 |
| 2017 |
Grazia Salerno, Alice Berardo, Tomoki Ozawa, Hannah M Price, Ludovic Taxis, Nicola M Pugno, Iacopo Carusotto Spin–orbit coupling in a hexagonal ring of pendula published pages: 55001, ISSN: 1367-2630, DOI: 10.1088/1367-2630/aa6c03 |
New Journal of Physics 19/5 | 2020-01-23 |
| 2017 |
Luca Valentini, Silvia Bittolo Bon, Miguel-Angel Lopez-Manchado, Lorenzo Mussolin, Nicola Pugno Development of conductive paraffin/graphene films laminated on fluoroelastomers with high strain recovery and anti-corrosive properties published pages: 254-261, ISSN: 0266-3538, DOI: 10.1016/j.compscitech.2017.06.023 |
Composites Science and Technology 149 | 2020-01-23 |
| 2017 |
M. Fraldi, G. Perrella, M. Ciervo, F. Bosia, N.M. Pugno A hybrid deterministic-probabilistic approach to model the mechanical response of helically arranged hierarchical strands published pages: 338-352, ISSN: 0022-5096, DOI: 10.1016/j.jmps.2017.05.013 |
Journal of the Mechanics and Physics of Solids 106 | 2020-01-23 |
| 2017 |
Gianluca Costagliola, Federico Bosia, Nicola M. Pugno Hierarchical Spring-Block Model for Multiscale Friction Problems published pages: 2845-2852, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.6b00709 |
ACS Biomaterials Science & Engineering 3/11 | 2020-01-23 |
| 2017 |
Q. Chen, F. Sun, Z. Y. Li, L. Taxis, N. Pugno Nonlinear mechanics of a ring structure subjected to multi-pairs of evenly distributed equal radial forces published pages: 942-953, ISSN: 0567-7718, DOI: 10.1007/s10409-017-0665-8 |
Acta Mechanica Sinica 33/5 | 2020-01-23 |
| 2017 |
Luca Valentini, Silvia Bittolo Bon, Nicola M. Pugno Graphene and Carbon Nanotube Auxetic Rubber Bionic Composites with Negative Variation of the Electrical Resistance and Comparison with Their Nonbionic Counterparts published pages: 1606526, ISSN: 1616-301X, DOI: 10.1002/adfm.201606526 |
Advanced Functional Materials 27/24 | 2020-01-23 |
| 2017 |
L. Felipe Barros, Juan P. Bolaños, Gilles Bonvento, Anne-Karine Bouzier-Sore, Angus Brown, Johannes Hirrlinger, Sergey Kasparov, Frank Kirchhoff, Anne N. Murphy, Luc Pellerin, Michael B. Robinson, Bruno Weber Current technical approaches to brain energy metabolism published pages: , ISSN: 0894-1491, DOI: 10.1002/glia.23248 |
Glia | 2020-01-23 |
| 2017 |
Raimonds Meija, Stefano Signetti, Arnim Schuchardt, Kerstin Meurisch, Daria Smazna, Matthias Mecklenburg, Karl Schulte, Donats Erts, Oleg Lupan, Bodo Fiedler, Yogendra Kumar Mishra, Rainer Adelung, Nicola M. Pugno Nanomechanics of individual aerographite tetrapods published pages: 14982, ISSN: 2041-1723, DOI: 10.1038/ncomms14982 |
Nature Communications 8 | 2020-01-23 |
| 2017 |
Gianluca Costagliola, Federico Bosia, Nicola M. Pugno Hierarchical Spring-Block Model for Multiscale Friction Problems published pages: 2845-2852, ISSN: 2373-9878, DOI: 10.1021/acsbiomaterials.6b00709 |
ACS Biomaterials Science & Engineering 3/11 | 2020-01-23 |
| 2017 |
Fabian Schütt, Stefano Signetti, Helge Krüger, Sarah Röder, Daria Smazna, Sören Kaps, Stanislav N. Gorb, Yogendra Kumar Mishra, Nicola M. Pugno, Rainer Adelung Hierarchical self-entangled carbon nanotube tube networks published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-017-01324-7 |
Nature Communications 8/1 | 2020-01-23 |
| 2017 |
Anja Scheller, Xianshu Bai, Frank Kirchhoff The Role of the Oligodendrocyte Lineage in Acute Brain Trauma published pages: 2479-2489, ISSN: 0364-3190, DOI: 10.1007/s11064-017-2343-4 |
Neurochemical Research 42/9 | 2020-01-23 |
| 2016 |
D. Misseroni, L. Afferrante, G. Carbone, N. M. Pugno Non-linear double-peeling: Experimental vs. theoretical predictions published pages: 46-57, ISSN: 0021-8464, DOI: 10.1080/00218464.2016.1255849 |
The Journal of Adhesion 94/1 | 2020-01-23 |
| 2017 |
Iryna Polishchuk, Avigail Aronhime Bracha, Leonid Bloch, Davide Levy, Stas Kozachkevich, Yael Etinger-Geller, Yaron Kauffmann, Manfred Burghammer, Carlotta Giacobbe, Julie Villanova, Gordon Hendler, Chang-Yu Sun, Anthony J. Giuffre, Matthew A. Marcus, Lakshminath Kundanati, Paul Zaslansky, Nicola M. Pugno, Pupa U. P. A. Gilbert, Alex Katsman, Boaz Pokroy Coherently aligned nanoparticles within a biogenic single crystal: A biological prestressing strategy published pages: 1294-1298, ISSN: 0036-8075, DOI: 10.1126/science.aaj2156 |
Science 358/6368 | 2020-01-23 |
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