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theEoE

A novel drug candidate for the treatment of Eosinophilic Esophagitis - an innovative solution for a significant unmet medical need

Total Cost €

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EC-Contrib. €

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Partnership

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 Outcomes and results

 theEoE project word cloud

Explore the words cloud of the theEoE project. It provides you a very rough idea of what is the project "theEoE" about.

manufacturing    approved    innovation    vomiting    europe2020    risk    efficacy    cure    series    elicited    healthier    cells    tissue    polarity    patented    revenue    causing    topical    diseases    indications    complications    company    pathologies    thelitetm    swallowing    local    bioavailability    reduces    eoe    environmental    line    white    modulation    theeoe    payers    eosinophilic    smarter    platform    benefit    cellular    epithelial    clinical    nausea    blood    perfectly    modifies    promotion    points    treatment    inflammatory    time    disease    thanks    drug    prioritized    esophagitis    first    lower    esophagus    discovery    therapy    occurs    applies    necessarily    investing    revolutionary    pain    fewer    28    spending    eosinophils    wellbeing    offers    progression    allergens    thelial    accumulate    injury    symptoms    fits    sustainable    integrity    patients    technologies    persistent    uncontrolled    decision    foods    remodeling    toxicology    generating    difficulty    candidate    possibly    health    fly    persists    proprietary    modulating    embryo    ip    people    cell    regurgitation    physicians    inflammation    barriers    compounds   

Project "theEoE" data sheet

The following table provides information about the project.

Coordinator		 THELIAL TECHNOLOGIES SA 

Organization address
address: PARQUE TECNOLOGICO DE CANTANHEDE, NUCLEO 4, LOTE 3
city: CANTANHEDE
postcode: 3060197
website: n.a.

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.
 Coordinator Country Portugal [PT]
 Project website http://www.thelial.com
 Total cost 71˙429 €
 EC max contribution 50˙000 € (70%)
 Programme 1. H2020-EU.3.1.3. (Treating and managing disease)
 Code Call H2020-SMEINST-1-2016-2017
 Funding Scheme SME-1
 Starting year 2016
 Duration (year-month-day) from 2016-12-01   to  2017-04-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    THELIAL TECHNOLOGIES SA PT (CANTANHEDE) coordinator 50˙000.00

Map

 Project objective

Thelial Technologies, S.A. is a revenue generating drug discovery company that applies its unique, proprietary fly embryo-based technology to find new candidate compounds for the treatment of diseases that can be addressed by cell polarity modulation. By modulating cell polarity it is possible to specifically target a series of indications, where reduced integrity of epithelial cellular barriers is a key to pathologies. Using Thelial’s patented discovery platform theLiTETM the company has identified 28 candidate compounds, of which one – theEoE has been prioritized for further development based on toxicology, efficacy, bioavailability, IP and manufacturing decision points. theEoE will be the first approved product for treatment of Eosinophilic Esophagitis (EoE). EoE is an inflammatory disease of the esophagus elicited by foods and possibly environmental allergens. It occurs when a type of white blood cells, eosinophils, accumulate in the esophagus and persists, causing local injury and inflammation. Currently, there are no specific cure for the EoE, causing patients’ reduced wellbeing due to uncontrolled and persistent symptoms (e.g. high difficulty in swallowing, pain, nausea, regurgitation, and vomiting). Thelial offers a targeted topical treatment that reduces the clinical symptoms, modifies disease progression through tissue remodeling, and increases the duration of treatment response. These features will allow physicians, patients and payers to benefit from a revolutionary new treatment with fewer side-effects, and lower risk of health complications thanks to a better management of the disease over time. By promoting a first in line targeted therapy for EoE, Thelial’s innovation project perfectly fits the “Europe2020 challenges – for a healthier EU” 1) spending smarter but not necessarily more in sustainable health systems and 2) investing in people’s health, particularly through health-promotion programmes.

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The information about "THEEOE" are provided by the European Opendata Portal: CORDIS opendata.

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