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SCALTIE

Single cell analysis of the lung tumour-immune ecosystem: Developing new tools for effective immunotherapy

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

SCALTIE project word cloud

Explore the words cloud of the SCALTIE project. It provides you a very rough idea of what is the project "SCALTIE" about.

interface patients unbiased tumour suppression malignant career biology subpopulations precise pathogenicity acquire complementary individual microenvironment medicine treatment combination ecosystem group killer roles diverse me cells diseases mentoring cellular stromal immunotherapies scientific genomics mutated biggest functional near succeed series tumours soft resolution immunotherapy urgent basis evade lack interactions techniques communicating skills holistic molecular populations single assays patient tools rate mechanisms unfortunately play activate genomic lung always surveillance characterization tissues immune provides health line cell bioinformatics cancer revolutionizing turned bulk checkpoints evolve

Project "SCALTIE" data sheet

The following table provides information about the project.

Coordinator	WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Israel [IL]
Total cost	170˙509 €
EC max contribution	170˙509 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-06-01 to 2019-05-31

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	WEIZMANN INSTITUTE OF SCIENCE WEIZMANN INSTITUTE OF SCIENCE Organization address address: HERZL STREET 234 city: REHOVOT postcode: 7610001 website: www.weizmann.ac.il contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IL (REHOVOT)	coordinator	170˙509.00

Map

Project objective

Tumours evolve to evade immune surveillance through a series of immune suppression mechanisms. In line with this, cancer immunotherapies, in which the immune system is turned on against tumours, are currently revolutionizing cancer treatment. Unfortunately, still many cancer patients do not respond to immunotherapies. Therefore, there is an urgent need to develop new tools for effective immunotherapy in order to increase treatment response rate. However, current methods that investigate bulk populations of cells lack the resolution to identify and analyse the diverse subpopulations of cells and the unique pathways and checkpoints they activate within the tumour ecosystem. I therefore aim to use advanced single cell genomic techniques for unbiased and high-resolution characterization of the different malignant, stromal and immune cell populations within the microenvironment of lung tumour, which is the biggest cancer killer in Europe. In combination with modelling approaches and advanced functional assays, I will identify subpopulations of cells specific to tumours, known and novel pathways mutated in tumour cells and cell-cell interactions that all together play crucial roles in the tumours pathogenicity. A comprehensive understanding of these processes provides the basis for understanding why existing cancer immunotherapies do not always succeed and provides new potential targets for the development of precise medicine tailored to individual patient. Complementary to my skills in molecular and cellular biology, I will acquire scientific skills in single cell genomics and bioinformatics, and soft skills in project management, mentoring, communicating, etc in this project. Those skills will enable me to establish my own research group in the near future to investigate the interface between the immune system and tissues under health and diseases with holistic approaches, which is my long-term career goal.

Publications

List of publications.
year	authors and title	journal	last update
2019	Hanjie Li, Anne M. van der Leun, Ido Yofe, Yaniv Lubling, Dikla Gelbard-Solodkin, Alexander C.J. van Akkooi, Marlous van den Braber, Elisa A. Rozeman, John B.A.G. Haanen, Christian U. Blank, Hugo M. Horlings, Eyal David, Yael Baran, Akhiad Bercovich, Aviezer Lifshitz, Ton N. Schumacher, Amos Tanay, Ido Amit Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma published pages: 775-789.e18, ISSN: 0092-8674, DOI: 10.1016/j.cell.2018.11.043	Cell 176/4	2019-10-28

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The information about "SCALTIE" are provided by the European Opendata Portal: CORDIS opendata.