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NEURO-SWARM

Efferent modulation of auditory sensitivity in mosquitoes: From auditory transduction to swarming behaviour

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
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NEURO-SWARM project word cloud

Explore the words cloud of the NEURO-SWARM project. It provides you a very rough idea of what is the project "NEURO-SWARM" about.

physiological upregulate modulates variations swarms temporal mosquito phenotypes believe mutants behavioural octopamine signalling johnston workers little mechanisms generate molecular chase amine sensitivity organ receptors characterization function insecticide disrupt secondly context hypothesize period connection mating thirdly biogenic hearing subsequently mosquitoes disrupting auditory firstly recognition considering tools induce efferent co acoustic attraction direct hear serotonin beat first multidisciplinary male altering innervating amines aggregate traps females biology involvement despite copulate jo impair insects discovered intimate males wing releases swarming

Project "NEURO-SWARM" data sheet

The following table provides information about the project.

Coordinator	UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	United Kingdom [UK]
Project website	https://www.researchgate.net/profile/Marta_Andres2
Total cost	183˙454 €
EC max contribution	183˙454 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-04-01 to 2019-05-01

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	UNIVERSITY COLLEGE LONDON UNIVERSITY COLLEGE LONDON Organization address address: GOWER STREET city: LONDON postcode: WC1E 6BT website: n.a. contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	UK (LONDON)	coordinator	183˙454.00

Map

Project objective

Hearing in mosquitoes is crucial for mating partner recognition. Within mating swarms, males hear the wing beat of females and chase them to copulate. Despite the importance of this behaviour, very little is known about the molecular mechanisms involved. I and my co-workers have recently discovered an auditory efferent system innervating the mosquito hearing organ, the Johnston's Organ (JO) that releases the biogenic amines octopamine and serotonin and modulates the auditory function. However, we still do not know how this efferent system modulates hearing in the context of swarming. Given the intimate connection between hearing and swarming in mosquitoes, and considering that biogenic amines have been described in other insects to induce swarming, I hypothesize that biogenic amines induce mosquitoes to aggregate into swarms and upregulate their auditory sensitivity to increase male mosquito attraction to females. My objectives are to use a multidisciplinary approach, including molecular biology, physiological and behavioural methods, to study if biogenic amines increase the auditory sensitivity during swarming and to assess the potential of disrupting biogenic amine signalling to impair mosquito hearing and swarming. To this end, I will first study temporal variations of biogenic amine signalling pathways in the mosquito JO during the swarming period. I will then generate mosquito mutants to impair biogenic amine signalling and subsequently use these mutants to assess their auditory function and swarming behaviour phenotypes aiming at defining a direct involvement of biogenic amines in mosquito hearing and mating. We believe that our work will lead to developing novel mosquito control tools. Firstly, improving our knowledge on mosquito hearing can lead to develop novel acoustic traps. Secondly, the characterization of biogenic amine receptors could directly identify new insecticide targets. Thirdly, altering swarming behaviour can disrupt mosquito mating.

Publications

List of publications.
year	authors and title	journal	last update
2018	Matthew P. Su, Marta AndrÃ©s, Nicholas Boyd-Gibbins, Jason Somers, Joerg T. Albert Sex and species specific hearing mechanisms in mosquito flagellar ears published pages: , ISSN: 2041-1723, DOI: 10.1038/s41467-018-06388-7	Nature Communications 9/1	2019-09-25

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