TOXANOID
Pharmacological safety testing in human adult stem cell-derived organoids
Total Cost €
0EC-Contrib. €
0Partnership
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0TOXANOID project word cloud
Explore the words cloud of the TOXANOID project. It provides you a very rough idea of what is the project "TOXANOID" about.
Project "TOXANOID" data sheet
The following table provides information about the project.
| Coordinator |
KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW
Organization address contact info |
| Coordinator Country | Netherlands [NL] |
| Total cost | 147˙500 € |
| EC max contribution | 147˙500 € (100%) |
| Programme |
1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC)) |
| Code Call | ERC-2016-PoC |
| Funding Scheme | ERC-POC |
| Starting year | 2017 |
| Duration (year-month-day) | from 2017-04-01 to 2018-09-30 |
Partnership
Take a look of project's partnership.
| # | ||||
|---|---|---|---|---|
| 1 | KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN - KNAW | NL (AMSTERDAM) | coordinator | 147˙500.00 |
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Project objective
Toxicology and pharmacology assays are crucial pillars of modern drug development. They are essential to understand how tissues such as intestine and liver take up and degrade pharmaceutically active compounds. Due to the lack of suitable in vitro systems, these assays are carried out in experimental animals. This practice increases cost and development time but also creates significant ethical issues.
We recently developed a 3D culture system that allows us to expand human tissue stem cells from intestine and liver as organoids and differentiate them to the respective functional adult tissue in vitro. These stem cell-derived tissues show high cytochrome activity and are able to metabolize drugs in a simple and cost-effective in vitro assay. With support from the ERC Proof of concept grant we aim to prove that our technology can outperform current in vitro systems and replace a significant portion of animal-based toxicology studies. This technological advance will lead to substantial reduction of cost in industrial and academic drug development and overcome practical and ethical pitfalls in animal-based testing.
To this end we will develop an organoid-based assay to test tissue-drug interactions in three steps:
1) Definition of optimal parameters for human in vitro assays to assess gastro-intestinal and hepatic toxicity 2) Scale-up 3) Technology transfer and commercial distribution
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The information about "TOXANOID" are provided by the European Opendata Portal: CORDIS opendata.