Opendata, web and dolomites

CondStruct SIGNED

Structural basis for the coordination of chromosome architecture by condensin complexes

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 CondStruct project word cloud

Explore the words cloud of the CondStruct project. It provides you a very rough idea of what is the project "CondStruct" about.

chromatin    intend    ray    anticipate    crystallography    dimensional    determines    chromosomes    shape    complementary    cellular    action    gene    electron    cell    protein    differentiation    fibres    experiments    entire    microscopy    mass    model    despite    condensin    molecule    reconstitution    division    plays    shaped    dynamic    biological    disease    rearrangements    genomes    invaluable    activates    fundamental    course    expression    atpase    molecular    dependent    chromosome    elusive    cycle    integrity    ranging    function    regulation    encircles    biology    confer    networks    fluorescence    helices    atomic    structures    undergo    near    first    structural    dna    cross    comprehension    mechanisms    technologies    gained    conformational    insights    functions    organisation    genomic    unravel    dramatic    integrative    core    machinery    ring    partitioning    interaction    architecture    implications    duplication    combine    mediated    reveal    linear    single    linkages    genome    mechanistic    engages    spectrometry    subunit    linking    biochemical    roles    topology    resolution   

Project "CondStruct" data sheet

The following table provides information about the project.

Coordinator
EUROPEAN MOLECULAR BIOLOGY LABORATORY 

Organization address
address: Meyerhofstrasse 1
city: HEIDELBERG
postcode: 69117
website: http://www.embl.de

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Germany [DE]
 Project website http://www.haering.embl.de
 Total cost 1˙982˙479 €
 EC max contribution 1˙982˙479 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2015-CoG
 Funding Scheme ERC-COG
 Starting year 2016
 Duration (year-month-day) from 2016-07-01   to  2021-06-30

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    EUROPEAN MOLECULAR BIOLOGY LABORATORY DE (HEIDELBERG) coordinator 1˙982˙479.00

Map

 Project objective

Chromosomes undergo dramatic changes in their three-dimensional organisation during all aspects of genome function, ranging from the regulation of gene expression during cellular differentiation to chromosome duplication and partitioning over the course of a cell division cycle. The multi-subunit condensin protein complex plays major roles for these changes in DNA topology. Despite its fundamental importance, the mechanisms of condensin’s action are not understood.

Here, I propose a comprehensive research program that aims to reveal the elusive mechanisms behind the functions of the condensin complex. We intend to unravel how the condensin complex engages DNA, how this interaction activates large-scale ATPase-dependent conformational rearrangements within the complex, and how condensin eventually encircles chromatin fibres within its ring-shaped architecture. Insights from these mechanistic studies will be invaluable for understanding how networks of condensin-mediated linkages can shape linear DNA helices into higher-order chromosome structures. To achieve this ambitious and timely goal, we will combine an integrative structural biology approach with biochemical and cell biological methods. By applying complementary technologies, including X-ray protein crystallography, electron microscopy, cross-linking mass spectrometry, single molecule fluorescence microscopy and reconstitution experiments, we anticipate to build the first model of the entire condensin complex at near-atomic resolution and explain how dynamic conformational changes confer function.

The insights gained from this research program will provide an in-depth mechanistic comprehension of the core molecular machinery that determines the architecture of our genomes and will have major implications for understanding how genomic integrity is affected in various disease conditions.

 Publications

year authors and title journal last update
List of publications.
2019 Markus Hassler, Indra A. Shaltiel, Marc Kschonsak, Bernd Simon, Fabian Merkel, Lena Thärichen, Henry J. Bailey, Jakub Macošek, Sol Bravo, Jutta Metz, Janosch Hennig, Christian H. Haering
Structural Basis of an Asymmetric Condensin ATPase Cycle
published pages: 1175-1188.e9, ISSN: 1097-2765, DOI: 10.1016/j.molcel.2019.03.037
Molecular Cell 74/6 2019-09-02
2017 Jorine M Eeftens, Shveta Bisht, Jacob Kerssemakers, Marc Kschonsak, Christian H Haering, Cees Dekker
Real‐time detection of condensin‐driven DNA compaction reveals a multistep binding mechanism
published pages: 3448-3457, ISSN: 0261-4189, DOI: 10.15252/embj.201797596
The EMBO Journal 36/23 2019-06-18
2017 Tsuyoshi Terakawa, Shveta Bisht, Jorine M. Eeftens, Cees Dekker, Christian H. Haering, Eric C. Greene
The condensin complex is a mechanochemical motor that translocates along DNA
published pages: 672-676, ISSN: 0036-8075, DOI: 10.1126/science.aan6516
Science 358/6363 2019-06-18
2017 Marc Kschonsak, Fabian Merkel, Shveta Bisht, Jutta Metz, Vladimir Rybin, Markus Hassler, Christian H. Haering
Structural Basis for a Safety-Belt Mechanism That Anchors Condensin to Chromosomes
published pages: 588-600.e24, ISSN: 0092-8674, DOI: 10.1016/j.cell.2017.09.008
Cell 171/3 2019-06-18
2018 Mahipal Ganji, Indra A. Shaltiel, Shveta Bisht, Eugene Kim, Ana Kalichava, Christian H. Haering, Cees Dekker
Real-time imaging of DNA loop extrusion by condensin
published pages: 102-105, ISSN: 0036-8075, DOI: 10.1126/science.aar7831
Science 360/6384 2019-04-20

Are you the coordinator (or a participant) of this project? Plaese send me more information about the "CONDSTRUCT" project.

For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.

Send me an  email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.

Thanks. And then put a link of this page into your project's website.

The information about "CONDSTRUCT" are provided by the European Opendata Portal: CORDIS opendata.

More projects from the same programme (H2020-EU.1.1.)

ENTRAPMENT (2019)

Septins: from bacterial entrapment to cellular immunity

Read More  

OSIRIS (2020)

Automatic measurement of speech understanding using EEG

Read More  

EASY-IPS (2019)

a rapid and efficient method for generation of iPSC

Read More