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TISSUENEU

Role of infiltrating neutrophils in tissue homeostasis

Total Cost €

EC-Contrib. €

Partnership

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Outcomes and
results

TISSUENEU project word cloud

Explore the words cloud of the TISSUENEU project. It provides you a very rough idea of what is the project "TISSUENEU" about.

homogenous homeostatic differentiated muscle healthy infiltrate educated spleen daily intestine eliminated shown back weather cells seq roles functionally explore host combine destination sc hypothesize transcriptome marrow single transgenic steady rna signature found mice inflammation tissue functioning mouse phenotypes follow population heterogeneity release sequencing modulate tissues neutrophils generation skin organs conception first stochastic regenerative favor hetroogeneity searching acquire terminally migration restricted models skeletal techniques homeostasis expand local mechanism source functions clearance neutrophil uncover blood lung bone signals multiple understand perform cell cycles laboratory

Project "TISSUENEU" data sheet

The following table provides information about the project.

Coordinator	CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 website: www.cnic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Project website	http://www.cnic.es
Total cost	158˙121 €
EC max contribution	158˙121 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-ST
Starting year	2017
Duration (year-month-day)	from 2017-05-01 to 2019-04-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) Organization address address: CALLE MELCHOR FERNANDEZ ALMAGRO 3 city: MADRID postcode: 28029 website: www.cnic.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	ES (MADRID)	coordinator	158˙121.00

Map

Project objective

Neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. After searching for the presence of neutrophils across multiple tissues of healthy mice under steady state, my host laboratory found neutrophils in most of the tissue analyzed. These findings require the study of the role of neutrophils in their tissue of destination. Several studies have shown that neutrophil clearance might be a significant source of homeostatic signals able to functionally modulate the tissues and organs where they are eliminated. In addition, specific functions for neutrophils in the spleen have already been described. I hypothesize that neutrophils may have important roles for the homeostasis and functioning of the tissues that they infiltrate, and that they acquire tissue-specific phenotypes that favor their local functions.

To understand neutrophil homeostatic functions within the tissue, I will first characterize the transcriptome of 7 different subsets of neutrophils population from intestine, lung, muscle, skin, spleen, blood and bone marrow by RNA-sequencing. In addition, to investigate weather neutrophil heterogeneity within the tissues is a stochastic or a tissue-educated mechanism I will perform single cell RNA sequencing (sc-RNA-seq) of blood neutrophils to characterize the presence of a neutrophil tissue-specific signature in the blood. Moreover, I will combine next generation sequencing techniques with the use of different transgenic mouse models to uncover tissue specific regenerative functions of neutrophils in the skeletal muscle and the skin.

Results obtained in this proposal aim to challenge the classical conception about neutrophils as a homogenous population of terminally differentiated cells with functions restricted to inflammation and to explore their hetroogeneity and expand our knowledge about their specific functions during tissue homeostasis.

Publications

List of publications.
year	authors and title	journal	last update
2018	Maria Casanova-Acebes, JosÃ© A. NicolÃ¡s-Ãvila, Jackson LiangYao Li, Susana GarcÃa-Silva, Akhila Balachander, Andrea Rubio-Ponce, Linnea A. Weiss, JosÃ© M. Adrover, Kyle Burrows, Noelia A-GonzÃ¡lez, Ivan Ballesteros, Sapna Devi, Juan A. Quintana, Georgiana Crainiciuc, Magdalena Leiva, Matthias Gunzer, Christian Weber, Takashi Nagasawa, Oliver Soehnlein, Miriam Merad, Arthur Mortha, Lai Guan Ng, Neutrophils instruct homeostatic and pathological states in naive tissues published pages: 2778-2795, ISSN: 0022-1007, DOI: 10.1084/jem.20181468	The Journal of Experimental Medicine 215/11	2019-09-25

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