Explore the words cloud of the TISSUENEU project. It provides you a very rough idea of what is the project "TISSUENEU" about.
The following table provides information about the project.
Coordinator |
CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.)
Organization address contact info |
Coordinator Country | Spain [ES] |
Project website | http://www.cnic.es |
Total cost | 158˙121 € |
EC max contribution | 158˙121 € (100%) |
Programme |
1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility) |
Code Call | H2020-MSCA-IF-2016 |
Funding Scheme | MSCA-IF-EF-ST |
Starting year | 2017 |
Duration (year-month-day) | from 2017-05-01 to 2019-04-30 |
Take a look of project's partnership.
# | ||||
---|---|---|---|---|
1 | CENTRO NACIONAL DE INVESTIGACIONESCARDIOVASCULARES CARLOS III (F.S.P.) | ES (MADRID) | coordinator | 158˙121.00 |
Neutrophils follow daily cycles of release from and migration back into the bone marrow, where they are eliminated. After searching for the presence of neutrophils across multiple tissues of healthy mice under steady state, my host laboratory found neutrophils in most of the tissue analyzed. These findings require the study of the role of neutrophils in their tissue of destination. Several studies have shown that neutrophil clearance might be a significant source of homeostatic signals able to functionally modulate the tissues and organs where they are eliminated. In addition, specific functions for neutrophils in the spleen have already been described. I hypothesize that neutrophils may have important roles for the homeostasis and functioning of the tissues that they infiltrate, and that they acquire tissue-specific phenotypes that favor their local functions.
To understand neutrophil homeostatic functions within the tissue, I will first characterize the transcriptome of 7 different subsets of neutrophils population from intestine, lung, muscle, skin, spleen, blood and bone marrow by RNA-sequencing. In addition, to investigate weather neutrophil heterogeneity within the tissues is a stochastic or a tissue-educated mechanism I will perform single cell RNA sequencing (sc-RNA-seq) of blood neutrophils to characterize the presence of a neutrophil tissue-specific signature in the blood. Moreover, I will combine next generation sequencing techniques with the use of different transgenic mouse models to uncover tissue specific regenerative functions of neutrophils in the skeletal muscle and the skin.
Results obtained in this proposal aim to challenge the classical conception about neutrophils as a homogenous population of terminally differentiated cells with functions restricted to inflammation and to explore their hetroogeneity and expand our knowledge about their specific functions during tissue homeostasis.
year | authors and title | journal | last update |
---|---|---|---|
2018 |
Maria Casanova-Acebes, José A. Nicolás-Ãvila, Jackson LiangYao Li, Susana GarcÃa-Silva, Akhila Balachander, Andrea Rubio-Ponce, Linnea A. Weiss, José M. Adrover, Kyle Burrows, Noelia A-González, Ivan Ballesteros, Sapna Devi, Juan A. Quintana, Georgiana Crainiciuc, Magdalena Leiva, Matthias Gunzer, Christian Weber, Takashi Nagasawa, Oliver Soehnlein, Miriam Merad, Arthur Mortha, Lai Guan Ng, Neutrophils instruct homeostatic and pathological states in naive tissues published pages: 2778-2795, ISSN: 0022-1007, DOI: 10.1084/jem.20181468 |
The Journal of Experimental Medicine 215/11 | 2019-09-25 |
Are you the coordinator (or a participant) of this project? Plaese send me more information about the "TISSUENEU" project.
For instance: the website url (it has not provided by EU-opendata yet), the logo, a more detailed description of the project (in plain text as a rtf file or a word file), some pictures (as picture files, not embedded into any word file), twitter account, linkedin page, etc.
Send me an email (fabio@fabiodisconzi.com) and I put them in your project's page as son as possible.
Thanks. And then put a link of this page into your project's website.
The information about "TISSUENEU" are provided by the European Opendata Portal: CORDIS opendata.