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Hepatocarcinoma IVM

Spatiotemporal dynamics of CD8+ T cell responses to hepatocellular carcinoma

Total Cost €

EC-Contrib. €

Partnership

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Hepatocarcinoma IVM project word cloud

Explore the words cloud of the Hepatocarcinoma IVM project. It provides you a very rough idea of what is the project "Hepatocarcinoma IVM" about.

capacity mechanistic bearing dissect dynamics limited data spatial function single recognize predict mouse spatiotemporal protective insights precise model functions temporal effector relies generate interactive cells combined tumor govern hepatocellular conduct cell resolution determinants imaging antigens techniques cd8 tumors unprecedented population ad intrahepatic deploy eliminating liver preliminary carcinoma home migrate behavior cancerous rules created hoc

Project "Hepatocarcinoma IVM" data sheet

The following table provides information about the project.

Coordinator	OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Italy [IT]
Total cost	168˙277 €
EC max contribution	168˙277 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-SE
Starting year	2017
Duration (year-month-day)	from 2017-07-01 to 2019-06-30

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	OSPEDALE SAN RAFFAELE SRL OSPEDALE SAN RAFFAELE SRL Organization address address: VIA OLGETTINA 60 city: MILANO postcode: 20132 website: www.hsr.it contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	IT (MILANO)	coordinator	168˙277.00

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Project objective

CD8 T cells have a key role in eliminating tumors that affect the liver. The protective capacity of these cells relies on their ability to migrate to the liver, recognize antigens and deploy effector functions. While some of the rules that characterize CD8 T cell behavior in the cancerous liver have been characterized at the population level, we have only limited knowledge of the precise dynamics of intrahepatic CD8 T cell conduct at the single-cell level. In preliminary data for this project we have developed advanced imaging techniques that allow us to dissect the interactive behavior of CD8 T cells within the mouse liver at an unprecedented level of spatial and temporal resolution. We predict that this approach, combined with a new model of hepatocellular carcinoma created ad hoc, will generate novel mechanistic insights into the spatiotemporal determinants that govern the capacity of CD8 T cells to home and function in the tumor-bearing liver.

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The information about "HEPATOCARCINOMA IVM" are provided by the European Opendata Portal: CORDIS opendata.