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INFISS SIGNED

Targeting infertility associated to defective Insulin/IGF-1 signalling

Total Cost €

0

EC-Contrib. €

0

Partnership

0

Views

0

 INFISS project word cloud

Explore the words cloud of the INFISS project. It provides you a very rough idea of what is the project "INFISS" about.

endocrine    inactivated    directed    trend    compounds    drugs    suffering    benefits    decline    sterility    mediated    bridge    frequently    impacts    wellness    combating    igf    commercial    suggesting    infertility    emanating    defective    women    rate    oocyte    syndrome    basic    lies    evolutionarily    signalling    mitosigage    later    metabolic    interaction    combat    pcos    suffer    tumbling    stg    first    fertility    hyperinsulinemia    identification    molecular    population    adult    causes    perform    downsides    negatively    motherhood    ovulation    scientific    mitochondrial    helping    link    erc    social    patenting    mental    metabolism    fold    ageing    disorder    suppress    polycystic    societal    understand    diabetes    economical    contributor    world    maturation    ovulatory    poc    resistance    modern    age    therapeutic    idea    thirds    societies    blocks    iis    initial    society    conserved    funds    tight    fourth    market    successful    ascertain    ovary    energy    birth    insulin    reproductive   

Project "INFISS" data sheet

The following table provides information about the project.

Coordinator
UNIVERSIDAD PABLO DE OLAVIDE 

Organization address
address: CARRETERA DE UTRERA KM 1
city: SEVILLA
postcode: 41013
website: www.upo.es

contact info
title: n.a.
name: n.a.
surname: n.a.
function: n.a.
email: n.a.
telephone: n.a.
fax: n.a.

 Coordinator Country Spain [ES]
 Total cost 150˙000 €
 EC max contribution 150˙000 € (100%)
 Programme 1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
 Code Call ERC-2016-PoC
 Funding Scheme ERC-POC
 Starting year 2017
 Duration (year-month-day) from 2017-05-01   to  2018-10-31

 Partnership

Take a look of project's partnership.

# participants  country  role  EC contrib. [€] 
1    UNIVERSIDAD PABLO DE OLAVIDE ES (SEVILLA) coordinator 150˙000.00

Map

 Project objective

Fertility decline is the largest contributor to population ageing in the world today, and infertility negatively impacts on the mental a social wellness of the population affected. One of the causes of birth rate tumbling is the trend of later motherhood in modern societies and the infertility associated to diabetes and polycystic ovary syndrome (PCOS). PCOS is the leading cause for ovulatory infertility, being the most common endocrine and metabolic disorder, affecting women in reproductive age. Women suffering from diabetes frequently suffer from infertility and PCOS, while two-thirds of adult women with PCOS suffer from insulin resistance and hyperinsulinemia. The ERC-StG MitoSigAge funds research directed to understand the process of ageing with a focus on insulin/IGF-1 signalling (IIS) and its interaction with mitochondrial metabolism. PCOS blocks oocyte maturation and ovulation, suggesting a tight link between mitochondrial energy metabolism and oocyte development mediated by IIS. One of the applications emanating from this research lies in the identification of molecular targets to combat diabetes-associated sterility. The objective of the ERC-PoC is four-fold: First, identify evolutionarily conserved molecular targets that, when inactivated, suppress sterility associated to defective IIS. Second, identify existing drugs for the identified targets and ascertain which compounds have the best therapeutic potential. Third, perform the necessary patenting of the compounds for this new application and the initial steps towards the valorisation of the identified products and their commercial potential. Fourth, market studies to evaluate the commercial potential of our technology. These steps will bridge a scientific idea from basic research to therapeutic applications. If successful, it will provide important societal and economical benefits, helping combating the downsides associated to our modern ageing society.

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The information about "INFISS" are provided by the European Opendata Portal: CORDIS opendata.

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