EU H2020 Project "INFISS (Targeting infertility associated to defective Insulin/IGF-1 signalling)": description, partecipants, costs and EC-fundings

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INFISS project word cloud

Explore the words cloud of the INFISS project. It provides you a very rough idea of what is the project "INFISS" about.

bridge diabetes motherhood lies wellness later link patenting defective economical population combating understand ascertain market birth energy reproductive metabolic syndrome stg initial mediated infertility pcos sterility disorder mitosigage helping fertility successful endocrine scientific suggesting adult iis blocks suffering insulin thirds funds world metabolism inactivated idea contributor emanating ovary identification therapeutic polycystic mental erc societies directed negatively igf compounds perform trend suppress tumbling evolutionarily social resistance ovulation basic drugs modern fourth ovulatory ageing suffer impacts conserved age causes fold molecular women commercial mitochondrial first tight signalling poc downsides combat societal society oocyte interaction benefits frequently hyperinsulinemia maturation rate decline

Project "INFISS" data sheet

The following table provides information about the project.

Coordinator	UNIVERSIDAD PABLO DE OLAVIDE Organization address address: CARRETERA DE UTRERA KM 1 city: SEVILLA postcode: 41013 website: www.upo.es contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Spain [ES]
Total cost	150˙000 €
EC max contribution	150˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2016-PoC
Funding Scheme	ERC-POC
Starting year	2017
Duration (year-month-day)	from 2017-05-01 to 2018-10-31

#	participants	country	role	EC contrib. [€]
1	UNIVERSIDAD PABLO DE OLAVIDE	ES (SEVILLA)	coordinator	150˙000.00

UNIVERSIDAD PABLO DE OLAVIDE

ES (SEVILLA)

coordinator

150˙000.00

Project objective

Fertility decline is the largest contributor to population ageing in the world today, and infertility negatively impacts on the mental a social wellness of the population affected. One of the causes of birth rate tumbling is the trend of later motherhood in modern societies and the infertility associated to diabetes and polycystic ovary syndrome (PCOS). PCOS is the leading cause for ovulatory infertility, being the most common endocrine and metabolic disorder, affecting women in reproductive age. Women suffering from diabetes frequently suffer from infertility and PCOS, while two-thirds of adult women with PCOS suffer from insulin resistance and hyperinsulinemia. The ERC-StG MitoSigAge funds research directed to understand the process of ageing with a focus on insulin/IGF-1 signalling (IIS) and its interaction with mitochondrial metabolism. PCOS blocks oocyte maturation and ovulation, suggesting a tight link between mitochondrial energy metabolism and oocyte development mediated by IIS. One of the applications emanating from this research lies in the identification of molecular targets to combat diabetes-associated sterility. The objective of the ERC-PoC is four-fold: First, identify evolutionarily conserved molecular targets that, when inactivated, suppress sterility associated to defective IIS. Second, identify existing drugs for the identified targets and ascertain which compounds have the best therapeutic potential. Third, perform the necessary patenting of the compounds for this new application and the initial steps towards the valorisation of the identified products and their commercial potential. Fourth, market studies to evaluate the commercial potential of our technology. These steps will bridge a scientific idea from basic research to therapeutic applications. If successful, it will provide important societal and economical benefits, helping combating the downsides associated to our modern ageing society.

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