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ProteinDynamics SIGNED

Visualizing the Conformational Dynamics of Proteins by Time-Resolved Electron Microscopy

Total Cost €

EC-Contrib. €

Partnership

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ProteinDynamics project word cloud

Explore the words cloud of the ProteinDynamics project. It provides you a very rough idea of what is the project "ProteinDynamics" about.

resolved time particle spatial builds incomplete dynamics liquid cell experimental static tools electron rely nanoscale technological reconstruction imaging absence detection direct combined conformational millisecond visualizing microsecond microseconds cryo microscopy graphene function benefit motions cameras resolution structures proteins single atomic techniques fundamentally advent necessarily observe biomedical amplitude machines timescale frequently domain dimensional near extrapolation

Project "ProteinDynamics" data sheet

The following table provides information about the project.

Coordinator	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	Switzerland [CH]
Total cost	2˙000˙000 €
EC max contribution	2˙000˙000 € (100%)
Programme	1. H2020-EU.1.1. (EXCELLENT SCIENCE - European Research Council (ERC))
Code Call	ERC-2017-STG
Funding Scheme	ERC-STG
Starting year	2018
Duration (year-month-day)	from 2018-03-01 to 2023-02-28

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE Organization address address: BATIMENT CE 3316 STATION 1 city: LAUSANNE postcode: 1015 website: www.epfl.ch contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	CH (LAUSANNE)	coordinator	2˙000˙000.00

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Project objective

The function of many proteins involves large-amplitude domain motions that occur on a timescale of microseconds to millisecond. In the absence of tools to directly observe these dynamics, our understanding of the function of proteins is necessarily incomplete and must frequently rely on extrapolation from known static structures. Here, the implementation of real-time imaging of single particle dynamics in liquid phase is proposed with both microsecond time resolution as well as near-atomic spatial resolution. The experimental approach builds on several recent technological advances, namely the advent of Time-Resolved (“Four-dimensional”) Electron Microscopy, graphene liquid cell technology, and direct electron detection cameras, which are combined with established single-particle reconstruction techniques in cryo-Electron Microscopy. Visualizing the conformational dynamics of proteins will fundamentally advance our understanding of these nanoscale machines and has the potential to greatly benefit biomedical applications.

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The information about "PROTEINDYNAMICS" are provided by the European Opendata Portal: CORDIS opendata.