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ExoDia SIGNED

Cross-talk between skeletal muscle and pancreatic islets: impact of exosomes

Total Cost €

EC-Contrib. €

Partnership

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ExoDia project word cloud

Explore the words cloud of the ExoDia project. It provides you a very rough idea of what is the project "ExoDia" about.

survival expertise stepping profile mass successful determined certain physiology peptides etiology resistance function myokines prevalence cells ed relative nevertheless secreted mode rare technologies stone post million insulin career t2d microvesicles leader conversation individuals rna cell implications functional insights energy innovative worldwide suggests obesity inter metabolism edge accounts communication muscle cutting populations independent omic beta collaborations create area micro explosion skeletal trained gt 370 mechanism disease centres prandial decreased obese communicable glucose deficiency therapies demonstrated underlying proliferation 50 perfectly candidate precise negatively exosomes biology resistant islets total translational secretion diabetes complement people organ

Project "ExoDia" data sheet

The following table provides information about the project.

Coordinator	CENTRE EUROPEEN D'ETUDE DU DIABETE Organization address address: BOULEVARD RENE LERICHE city: STRASBOURG postcode: 67200 website: www.ceed-diabete.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.
Coordinator Country	France [FR]
Total cost	185˙076 €
EC max contribution	185˙076 € (100%)
Programme	1. H2020-EU.1.3.2. (Nurturing excellence by means of cross-border and cross-sector mobility)
Code Call	H2020-MSCA-IF-2016
Funding Scheme	MSCA-IF-EF-SE
Starting year	2018
Duration (year-month-day)	from 2018-01-02 to 2020-01-01

Partnership

Take a look of project's partnership.

#	participants	country	role	EC contrib. [€]
1	CENTRE EUROPEEN D'ETUDE DU DIABETE CENTRE EUROPEEN D'ETUDE DU DIABETE Organization address address: BOULEVARD RENE LERICHE city: STRASBOURG postcode: 67200 website: www.ceed-diabete.org contact info title: n.a. name: n.a. surname: n.a. function: n.a. email: n.a. telephone: n.a. fax: n.a.	FR (STRASBOURG)	coordinator	185˙076.00

Map

Project objective

The worldwide explosion of obesity has resulted in an ever-increasing prevalence of type 2 diabetes (T2D), a non-communicable disease that affects more than 370 million people worldwide. T2D is characterized by insulin resistance with a relative deficiency in insulin secretion. It is now recognized that there is decreased beta-cell function and mass in T2D but the precise underlying mechanism remains to be determined. Skeletal muscle accounts for >50% of the total glucose uptake in the post-prandial state, it is also the largest organ in non-obese individuals. Recent studies demonstrated that there is conversation between skeletal muscle and beta-cells, and that certain peptides (i.e. myokines) secreted by insulin-resistant skeletal muscle cells may impact negatively on beta-cell function, proliferation and survival in T2D. Nevertheless, other factors than myokines could also be involved in this inter-organ communication. A novel concept suggests microvesicles, such as exosomes, as a new cell-to-cell communication mode. The major goal of the project will be to characterize the different exosomes populations and their impact on islets cells. The findings may have important implications for understanding decreased functional beta-cell mass in diabetes, especially in T2D etiology, and therefore bring new insights into the development of innovative therapies. To achieve the aims of the innovative translational project, the candidate will be part of one of the European leader research centres on diabetes, trained to promising new research area in inter-organ communication, micro-RNA biology, as well as cutting-edge 'omic' technologies which will perfectly complement her strong knowledge in energy metabolism and physiology and create a rare expertise in candidate's profile. It will provide a unique stepping-stone for her independent research career in Europe and successful collaborations in the future.

Publications

List of publications.
year	authors and title	journal	last update
2019	Maria L. Mizgier, Rodrigo FernÃ¡ndez-Verdejo, Julien Cherfan, Michel Pinget, Karim Bouzakri, Jose E. Galgani Insights on the Role of Putative Muscle-Derived Factors on Pancreatic Beta Cell Function published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.01024	Frontiers in Physiology 10	2019-11-22
2019	Sophie Rome, Alexis Forterre, Maria Luisa Mizgier, Karim Bouzakri Skeletal Muscle-Released Extracellular Vesicles: State of the Art published pages: , ISSN: 1664-042X, DOI: 10.3389/fphys.2019.00929	Frontiers in Physiology 10	2019-11-22

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The information about "EXODIA" are provided by the European Opendata Portal: CORDIS opendata.