Explore the words cloud of the TAXINOMISIS project. It provides you a very rough idea of what is the project "TAXINOMISIS" about.
The following table provides information about the project.
Coordinator |
PANEPISTIMIO IOANNINON
Organization address contact info |
Coordinator Country | Greece [EL] |
Project website | https://taxinomisis-project.eu/ |
Total cost | 5˙999˙402 € |
EC max contribution | 5˙999˙402 € (100%) |
Programme |
1. H2020-EU.3.1.1. (Understanding health, wellbeing and disease) |
Code Call | H2020-SC1-2017-Two-Stage-RTD |
Funding Scheme | RIA |
Starting year | 2018 |
Duration (year-month-day) | from 2018-01-01 to 2022-12-31 |
Take a look of project's partnership.
Carotid artery disease, the primary trigger of ischaemic cerebrovascular events including stroke, causes major morbidity, mortality and healthcare costs worldwide. Still, treatment is based on criteria established in the 90s that do not take into account the molecular evolution we have witnessed since, nor the introduction of new medication, leading to remarkably high unnecessary surgical treatment while missing most patients at risk. TAXINOMISIS will provide novel disease mechanism-based stratification for carotid artery disease patients to address the needs for stratified and personalised therapeutic interventions in the current era. This will be achieved through (1) the dissection of mechanisms mediating carotid artery disease, and identification of susceptibility and protection factors of plaque erosion and/or rupture using longitudinal cohorts and multi-omics, (2) the definition of distinct disease phenotypes and endotypes, and generation of molecular fingerprints of high versus low-risk states through systems medicine, (3) the development of a multilevel risk prediction model of the symptomatic plaque incorporating new biomarkers and advanced imaging, implemented in a software, to assist patient stratification and clinical decision making, (4) the development of novel pharmacogenomics solutions based on lab-on-a-chip technology to support personalized treatment, (5) the evaluation of the new risk prediction model and lab-on-a-chip device in a prospective observational clinical study, and (6) the assessment of regulatory, cost-effectiveness and ethical issues towards the implementation and commercialization of the programme’s outcomes. TAXINOMISIS has therefore the potential to rationally change the current state-of-the-art in the stratification of patients with carotid artery disease by reducing unnecessary operations, refining medical treatment and opening up new avenues for therapeutic intervention, while strengthening the European biotechnology sector.
Communication and dissemination activities v1 | Documents, reports | 2019-07-23 16:14:48 |
Project handbook, risk management and quality assurance plan | Documents, reports | 2019-07-22 16:48:55 |
First study subject approvals package | Documents, reports | 2019-06-19 12:08:48 |
Project presentation material | Other | 2019-06-19 12:08:48 |
Midterm recruitment report | Documents, reports | 2019-06-19 12:08:48 |
Take a look to the deliverables list in detail: detailed list of TAXINOMISIS deliverables.
year | authors and title | journal | last update |
---|---|---|---|
2019 |
Djorovic Smiljana; Saveljic Igor; Filipovic Nenad Computational modelling of carotid artery and simulation of plaque progression published pages: , ISSN: , DOI: 10.5281/zenodo.3253189 |
2 | 2019-08-29 |
2019 |
Djorovic Smiljana; Saveljic Igor; Filipovic Nenad Analysis of the carotid artery and atherosclerotic plaque growth using the patient-specific parameters published pages: , ISSN: , DOI: 10.5281/zenodo.3253178 |
2 | 2019-08-29 |
2019 |
Djorovic Smiljana; Saveljic Igor; Filipovic Nenad Carotid atherosclerosis disease: modelling and analysis of plaque development published pages: , ISSN: , DOI: 10.5281/zenodo.3253204 |
2 | 2019-08-29 |
2019 |
Djorovic Smiljana; Saveljic Igor; Filipovic Nenad Three-dimensional numerical analysis of atherosclerosis development within carotid artery published pages: , ISSN: , DOI: 10.5281/zenodo.3253176 |
2 | 2019-08-29 |
2018 |
Tuukka Taipale, Ilkka Seppälä, Emma Raitoharju, Nina Mononen, Leo-Pekka Lyytikäinen, Thomas Illig, Melanie Waldenberger, Markus Juonala, Nina Hutri-Kähönen, Niku Oksala, Mika Kähönen, Olli Raitakari, Terho Lehtimäki Fatty liver is associated with blood pathways of inflammatory response, immune system activation and prothrombotic state in Young Finns Study published pages: , ISSN: 2045-2322, DOI: 10.1038/s41598-018-28563-y |
Scientific Reports 8/1 | 2019-08-29 |
2019 |
Vassiliki T. Potsika, Michalis D. Mantzaris, Panagiotis K. Siogkas, Ioannis G. Pappas, Themis P. Exarchos, Dimitrios I. Fotiadis A Multilevel Approach to Evaluate Numerically Plaque Progression in Carotid Artery Disease published pages: , ISSN: , DOI: 10.5281/zenodo.3250568 |
8th Panhellenic Congress of Biomedical Technology 1 | 2019-08-29 |
2019 |
Michalis D. Mantzaris, Vassiliki T. Potsika, Panagiotis K. Siogkas, Ioannis G. Pappas, Themis P. Exarchos, Member, IEEE, Igor B. Koncar, Jaroslav Pelisek, Evangelos Andreakos and Dimitrios I. Fotiadis Computational modeling and big data approaches for the stratification of carotid artery disease published pages: , ISSN: , DOI: 10.5281/zenodo.3250574 |
Computational modeling and big data approaches for the stratification of carotid artery disease 1 | 2019-08-29 |
2018 |
Pashupati P. Mishra
Leo-Pekka Lyytikäinen
Mika Kähönen
Olli T. Raitakari
Reijo Laaksonen
Terho Lehtimäki Ceramides improve prediction accuracy of subclinical atherosclerosis published pages: , ISSN: , DOI: 10.5281/zenodo.3250838 |
European Conference on Computational Biology 2018 | 2019-08-29 |
2019 |
Pashupati P. Mishra
Leo-Pekka Lyytikäinen
Binisha H. Mishra
Mika Kähönen
Olli T. Raitakari
Reijo Laaksonen
Terho Lehtimäki Lipidome improves predictive ability of subclinical atherosclerosis over traditional risk factors: The Cardiovascular Risk in Young Finns Study published pages: , ISSN: , DOI: 10.5281/zenodo.3250843 |
15th Annual conference of the Metabolomics Society | 2019-08-29 |
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The information about "TAXINOMISIS" are provided by the European Opendata Portal: CORDIS opendata.